SOPH · SOPHiA GENETICS SA

Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $7.43 to $7.62, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $7.40 to $7.60, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $7.50 to $7.80, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $7.40 to $7.56, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $7.20 to $7.27, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $7.00 to $7.08, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

The share options are fully vested and exercisable.

Following the transaction reported on this line, the Reporting Person holds an aggregate total of 975,041 derivative share options across all remaining grant tranches with varying exercise prices.

Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

The share options are fully vested and exercisable.

Following the transaction reported on this line, the Reporting Person holds an aggregate total of 982,041 derivative share options across all remaining grant tranches with varying exercise prices.

Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $6.95 to $6.98, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $6.90 to $6.95, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $6.90 to $6.98, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $5.57 to $5.83, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $6.60 to $6.72, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

The share options are fully vested and exercisable.

Following the transaction reported on this line, the Reporting Person holds an aggregate total of 4,641,476 derivative share options across all remaining grant tranches with varying exercise prices.

Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $6.30 to $6.37, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $6.10 to $6.20, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $5.54 to $5.79, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $5.55 to $5.79, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $5.53 to $5.77, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Represents shares sold by the Reporting Person in the open market to satisfy tax withholding obligations arising in connection with the vesting of restricted stock units on July 3, 2026. These sales were effected pursuant to a pre-established Rule 10b5-1(c) trading plan adopted by the Reporting Person and do not represent discretionary trades.

Represents shares sold by the Reporting Person in the open market to satisfy tax withholding obligations arising in connection with the vesting of restricted stock units on July 2, 2026 and July 3, 2026. These sales were effected pursuant to a pre-established Rule 10b5-1(c) trading plan adopted by the Reporting Person and do not represent discretionary trades.

The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $4.95 to $5.34, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Represents shares sold by the Reporting Person in the open market to satisfy tax withholding obligations arising in connection with the vesting of restricted stock units on July 2 and July 3, 2026. These sales were effected pursuant to a pre-established Rule 10b5-1(c) trading plan adopted by the Reporting Person and do not represent discretionary trades.

The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $4.97 to $5.43, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Represents shares sold by the Reporting Person in the open market to satisfy tax withholding obligations arising in connection with the vesting of restricted stock units on July 2 and July 3, 2026. These sales were effected pursuant to a pre-established Rule 10b5-1(c) trading plan adopted by the Reporting Person and do not represent discretionary trades.

The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $4.97 to $5.44, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Represents shares sold by the Reporting Person in the open market to satisfy tax withholding obligations arising in connection with the vesting of restricted stock units on July 2 and July 3, 2026. These sales were effected pursuant to a pre-established Rule 10b5-1(c) trading plan adopted by the Reporting Person and do not represent discretionary trades.

The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $4.97 to $5.43, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Represents shares sold by the Reporting Person in the open market to satisfy tax obligations in connection with the vesting of restricted stock units on July 2, 2026. The sales were effected as a "sell to cover" transaction and do not represent discretionary trades.

Represents shares sold by the Reporting Person in the open market to satisfy tax obligations in connection with the vesting of restricted stock units on July 3, 2026. The sales were effected as a "sell to cover" transaction and do not represent discretionary trades.

Represents shares sold by the Reporting Person in the open market to satisfy tax withholding obligations arising in connection with the vesting of restricted stock units on July 2 and July 3, 2026. These sales were effected pursuant to a pre-established Rule 10b5-1(c) trading plan adopted by the Reporting Person and do not represent discretionary trades.

The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $4.97 to $5.43, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Represents shares sold by the Reporting Person in the open market to satisfy tax obligations in connection with the vesting of restricted stock units on July 2, 2026. The sales were effected as a "sell to cover" transaction and do not represent discretionary trades.

Represents shares sold by the Reporting Person in the open market to satisfy tax withholding obligations arising in connection with the vesting of restricted stock units on July 2 and July 3, 2026. These sales were effected pursuant to a pre-established Rule 10b5-1(c) trading plan adopted by the Reporting Person and do not represent discretionary trades.

The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $4.97 to $5.41, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Represents shares sold by the Reporting Person in the open market to satisfy tax withholding obligations arising in connection with the vesting of restricted stock units on July 2, 2026. These sales were effected pursuant to a pre-established Rule 10b5-1(c) trading plan adopted by the Reporting Person and do not represent discretionary trades.

The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $4.97 to $5.43, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $6.00 to $6.03, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $6.10 to $6.30, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

The share options are fully vested and exercisable.

Following the transaction reported on this line, the Reporting Person holds an aggregate total of 4,646,057 derivative stock options across all remaining grant tranches with varying exercise prices.

Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

The share options are fully vested and exercisable.

Following the transaction reported on this line, the Reporting Person holds an aggregate total of 4,691,476 derivative stock options across all remaining grant tranches with varying exercise prices.

Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

The share options are fully vested and exercisable.

Following the transaction reported on this line, the Reporting Person holds an aggregate total of 4,709,536 derivative stock options across all remaining grant tranches with varying exercise prices.

Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $5.70 to $5.78, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $5.80 to $5.94, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $5.30 to $5.69, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Represents shares sold by the Reporting Person in the open market to satisfy tax withholding obligations arising in connection with the vesting of restricted stock units. These sales were effected pursuant to a pre-established Rule 10b5-1(c) trading plan adopted by the Reporting Person and do not represent discretionary trades.

The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $5.31 to $5.69, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.