VRTX · Vertex Pharmaceuticals Inc / Ma

$546.12 -11.84 (-2.12%) At close · Sep 4

S&P 500 member Nasdaq-100 member Russell 1000 member Rebalance outlook locked

Market Cap

$141.42B

253.46M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Use institutional holdings through the 13F API or MCP →

Quarter:

Holders: 1,753

Total Value: $120,989,810,054

Total Shares: 244,079,171

Showing 1–100 of 1,806 holdings by value · page 1 of 19

Institutional Ownership Trend

26 quarters

Superinvestors Holding VRTX

All superinvestors →

Tweedy Browne $19,929,304 Joel Greenblatt $9,430,915 Ray Dalio $5,396,971

Holder Concentration

Across 1,753 13F filers · Δ vs Mar 31, 2026

Top Holder

10.7%

−0.1 pts

Top 5

40.3%

−1.6 pts

Top 10

52.7%

−0.9 pts

HHI

408

Broadly held−22

Quarterly Activity

vs Mar 31, 2026

New

192

Increased

705

Decreased

618

Sold Out

145

Unchanged

238

Holder count: +47

Institutional value: +15.1%

Shares held: +3.7%

Top Buyers

vs Mar 31, 2026

Institution	Added	Now Holds
Mega Invesco Ltd.	+5,481,995	8,043,052
Mega FRANKLIN RESOURCES INC	+2,796,121	3,347,253
Mega Capital World Investors	+746,890	26,115,014
Large Hudson Bay Capital Management LP	+595,440	640,440
Mega SG Americas Securities, LLC	+466,738	523,720

Top Sellers

vs Mar 31, 2026

Institution	Sold	Now Holds
Mega Capital Research Global Investors	−1,635,327	19,490,637
Mega ALLIANCEBERNSTEIN L.P.	−891,471	3,019,315
Mega FMR LLC	−563,107	1,457,158
Mega JPMORGAN CHASE & CO	−515,556	6,517,600
Mega Capital International Investors	−430,933	4,695,144

Top New Positions

vs Mar 31, 2026

Institution	Acquired	Value (USD)
Mega NORGES BANK	2,971,681	$1,476,123,103
Mega Jupiter Topco LLC	1,259,997	$625,878,307
Large Nykredit A/S	248,068	$123,222,817
Mid Harvest Portfolios Group Inc.	148,195	$73,612,902
Large Mn Services Vermogensbeheer B.V.	74,100	$36,807,693

Top Sold-Out Positions

vs Mar 31, 2026

Institution	Previously Held	Last Value (USD)
Mega JANUS HENDERSON GROUP PLC	2,131,527	$951,812,064
Small DIADEMA PARTNERS LP	96,940	$43,287,587
Mid Eversept Partners, LP	90,000	$40,188,600
Mid Smith Group Asset Management, LLC	55,746	$24,892,818
Mid Reynders McVeigh Capital Management, LLC	54,664	$24,409,662

Filter: New 192 Increased 705 Reduced 618 Sold out 145 Unchanged 238

Showing 100 of 1,806

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

Capital World Investors

$12,972,110,904

10.72%

26,115,014

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
CAPITAL GROUP COMPANIES INC joint	26,115,014	$12,972,110,904	100.0%	Defined

BlackRock, Inc.

$11,975,848,839

9.90%

24,109,373

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE	786,707	$390,780,968	3.3%	Sole
BlackRock Investment Management (Australia) Ltd	223,520	$111,029,089	0.9%	Sole
BlackRock Asset Management Canada Ltd	304,633	$151,320,350	1.3%	Sole
BLACKROCK (SINGAPORE) LTD.	31,538	$15,665,870	0.1%	Sole
BlackRock Asset Management North Asia Ltd	49,149	$24,413,782	0.2%	Sole
BlackRock Investment Management, LLC	581,208	$288,703,449	2.4%	Sole
BLACKROCK ADVISORS LLC	712,216	$353,779,053	3.0%	Sole
BlackRock Fund Advisors	9,268,752	$4,604,067,180	38.4%	Sole
BlackRock Institutional Trust Company, N.A.	5,356,444	$2,660,706,428	22.2%	Sole
BlackRock Japan Co. Ltd	315,854	$156,894,157	1.3%	Sole
BlackRock Fund Managers Ltd.	258,438	$128,373,907	1.1%	Sole
BlackRock Investment Management (UK) Ltd.	754,590	$374,827,490	3.1%	Sole
BlackRock (Netherlands) B.V.	740,071	$367,615,467	3.1%	Sole
BlackRock International, Ltd.	8,195	$4,070,702	0.0%	Sole
BlackRock Asset Management Ireland Ltd	3,258,573	$1,618,630,966	13.5%	Sole
BlackRock Advisors (UK) Ltd	25,007	$12,421,727	0.1%	Sole
BlackRock Asset Management Deutschland AG	69,314	$34,430,343	0.3%	Sole
BlackRock (Luxembourg) S.A.	789,358	$392,097,799	3.3%	Sole
BlackRock Life Ltd	76,478	$37,988,916	0.3%	Sole
BlackRock Asset Management Schweiz AG	9,594	$4,765,627	0.0%	Sole
Aperio Group, LLC	485,587	$241,205,630	2.0%	Sole
SpiderRock Advisors, LLC	4,147	$2,059,939	0.0%	Sole

Capital Research Global Investors

$9,681,584,117

8.00%

19,490,637

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
CAPITAL GROUP COMPANIES INC joint	19,490,637	$9,681,584,117	100.0%	Defined

VANGUARD CAPITAL MANAGEMENT LLC

$8,236,137,568

6.81%

16,580,713

STATE STREET CORP

$5,896,909,829

4.87%

11,871,459

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STATE STREET GLOBAL ADVISORS (JAPAN) CO., LTD. joint	11,871,459	$5,896,909,829	100.0%	Defined

Invesco Ltd.

$3,995,225,212

3.30%

8,043,052

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invesco Advisers, Inc. joint	476,468	$236,675,947	5.9%	Defined
Invesco Trust Co joint	105,916	$52,611,654	1.3%	Defined
Invesco Management S.A. joint	9,488	$4,712,973	0.1%	Defined
Invesco Taiwan Ltd	720	$357,645	0.0%	Defined
Invesco Asset Management (Japan) Limited joint	6,701	$3,328,586	0.1%	Defined
Invesco Investment Advisers LLC	6,572	$3,264,509	0.1%	Defined
Invesco Capital Management LLC	7,428,195	$3,689,807,302	92.4%	Defined
Invesco Managed Accounts, LLC	8,992	$4,466,596	0.1%	Defined

JPMORGAN CHASE & CO

$3,237,487,438

2.68%

6,517,600

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
J.P. Morgan Trust Co of Delaware	11,199	$5,562,878	0.2%	Other
JPMorgan Chase Bank, N.A.	605,047	$300,544,995	9.3%	Other
J.P. Morgan Investment Management Inc.	4,794,268	$2,381,456,743	73.6%	Defined
J.P. Morgan Securities LLC	244,984	$121,690,902	3.8%	Defined
J.P. Morgan Securities plc	87,680	$43,553,286	1.3%	Defined
JPMorgan Asset Management (UK) Ltd	439,403	$218,264,652	6.7%	Defined
JPMorgan Asset Management (Canada) Inc.	72,230	$35,878,807	1.1%	Defined
J.P. Morgan (Suisse) SA	2,979	$1,479,758	0.0%	Other
JPMorgan Asset Management (Asia Pacific) Ltd	16,531	$8,211,443	0.3%	Defined
JPMorgan Asset Management (Japan) Ltd	57,409	$28,516,772	0.9%	Defined
55I, LLC	1,171	$581,670	0.0%	Other
J.P. Morgan SE	83,023	$41,240,014	1.3%	Defined
J.P. MORGAN MANSART MANAGEMENT Ltd	101,676	$50,505,518	1.6%	Other

GEODE CAPITAL MANAGEMENT, LLC

$2,989,245,636

2.47%

6,017,848

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC	839,146	$416,828,992	13.9%	Defined
Held directly	5,178,702	$2,572,416,644	86.1%	Defined

VANGUARD PORTFOLIO MANAGEMENT LLC

$2,423,539,212

2.00%

4,878,987

Capital International Investors

$2,332,218,879

1.93%

4,695,144

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
CAPITAL GROUP COMPANIES INC joint	4,695,144	$2,332,218,879	100.0%	Defined

LOOMIS SAYLES & CO L P

$1,947,654,982

1.61%

3,920,953

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
LOOMIS SAYLES TRUST COMPANY, LLC	491,178	$243,982,847	12.5%	Defined
Held directly	3,429,775	$1,703,672,135	87.5%	Defined

FRANKLIN RESOURCES INC

$1,662,680,977

1.37%

3,347,253

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
FIDUCIARY TRUST CO INTERNATIONAL	37,188	$18,472,395	1.1%	Defined
Fiduciary Trust Co International of Pennsylvania	3,540	$1,758,424	0.1%	Defined
FIDUCIARY TRUST Co OF CANADA	395	$196,208	0.0%	Defined
Fiduciary Trust International of California	10,186	$5,059,691	0.3%	Defined
Fiduciary Trust International of the South	384	$190,744	0.0%	Defined
FIDUCIARY TRUST INTERNATIONAL LLC	3,738	$1,856,776	0.1%	Defined
FRANKLIN ADVISERS INC	404,950	$201,150,813	12.1%	Defined
FRANKLIN ADVISORY SERVICES LLC	9,947	$4,940,973	0.3%	Defined
Franklin Templeton International Services S.a r.l	1,089	$540,938	0.0%	Defined
PUTNAM INVESTMENT MANAGEMENT LLC	2,220,946	$1,103,210,506	66.4%	Defined
PUTNAM ADVISORY CO LLC	654,572	$325,145,549	19.6%	Other
Held directly	318	$157,960	0.0%	Defined

WELLINGTON MANAGEMENT GROUP LLP

$1,613,209,155

1.33%

3,247,658

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Wellington Management Company LLP	3,083,221	$1,531,528,367	94.9%	Defined
Wellington Managment Canada LLC	11,890	$5,906,119	0.4%	Defined
Wellington Management Hong Kong Ltd	19,409	$9,641,032	0.6%	Defined
Wellington Management Japan Pte Ltd	9,255	$4,597,236	0.3%	Defined
Wellington Management Singapore Pte. Ltd.	17,757	$8,820,434	0.5%	Defined
Wellington Management International Ltd	41,570	$20,649,066	1.3%	Defined
Wellington Trust Company, NA joint	57,077	$28,351,858	1.8%	Defined
Wellington Management Australia Pty Ltd	7,479	$3,715,043	0.2%	Defined

MORGAN STANLEY

$1,610,467,694

1.33%

3,242,139

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC	3,365	$1,671,496	0.1%	Defined
MORGAN STANLEY & CO. LLC	360,408	$179,025,465	11.1%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	534,797	$265,649,713	16.5%	Defined
MORGAN STANLEY AIP GP LP	23,991	$11,917,048	0.7%	Defined
MORGAN STANLEY INVESTMENT MANAGEMENT INC	40,283	$20,009,774	1.2%	Defined
Morgan Stanley Investment Management LTD	13,960	$6,934,350	0.4%	Defined
MORGAN STANLEY SMITH BARNEY LLC	328,139	$162,996,484	10.1%	Defined
Morgan Stanley Strategic Investments, Inc	5	$2,483	0.0%	Defined
MORGAN STANLEY LATAM LLC	1	$496	0.0%	Defined
Parametric Sas	2,546	$1,264,674	0.1%	Defined
Morgan Stanley Bank, N.A.	511	$253,829	0.0%	Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC	1,417,218	$703,974,696	43.7%	Defined
EATON VANCE MANAGEMENT	65,388	$32,480,181	2.0%	Defined
Calvert Research & Management	38,496	$19,122,117	1.2%	Defined
BOSTON MANAGEMENT & RESEARCH	355,747	$176,710,207	11.0%	Defined
Eaton Vance Advisers International Ltd	57,284	$28,454,681	1.8%	Defined

UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC

$1,533,248,041

1.27%

3,086,683

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Group AG	316,159	$157,045,659	10.2%	Defined
UBS Asset Management Switzerland AG	949,546	$471,667,983	30.8%	Defined
UBS Asset Management (UK) Ltd.	1,129,735	$561,173,266	36.6%	Defined
UBS Asset Management Life Ltd.	28,227	$14,021,197	0.9%	Defined
Held directly	663,016	$329,339,936	21.5%	Defined

BANK OF AMERICA CORP /DE/

$1,509,650,884

1.25%

3,039,178

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF AMERICA NA	466,237	$231,593,905	15.3%	Defined
MERRILL LYNCH, PIERCE, FENNER & SMITH INC.	484,501	$240,666,181	15.9%	Defined
BOFA SECURITIES, INC.	165,540	$82,228,684	5.4%	Defined
MERRILL LYNCH INTERNATIONAL	44,464	$22,086,602	1.5%	Defined
U.S. TRUST Co OF DELAWARE	7,417	$3,684,246	0.2%	Defined
MANAGED ACCOUNT ADVISORS LLC joint	1,865,652	$926,725,317	61.4%	Defined
BofA Securities Europe SA	5,367	$2,665,949	0.2%	Defined

ALLIANCEBERNSTEIN L.P.

$1,499,784,339

1.24%

3,019,315

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Equitable Holdings, Inc.	3,019,315	$1,499,784,339	100.0%	Defined

JENNISON ASSOCIATES LLC

$1,489,459,806

1.23%

2,998,530

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Prudential Financial Inc	2,932,240	$1,456,531,575	97.8%	Defined
Prudential Trust Company	66,290	$32,928,231	2.2%	Other

NORGES BANK

$1,476,123,103

1.22%

2,971,681

AMERIPRISE FINANCIAL INC

$1,293,893,227

1.07%

2,604,822

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Columbia Management Investment Advisers, LLC joint	1,916,422	$951,944,299	73.6%	Defined
Ameriprise Trust Co	519	$257,802	0.0%	Defined
Threadneedle Asset Management Holdings LTD	413,893	$205,593,069	15.9%	Defined
Ameriprise Financial Services, LLC joint	129,202	$64,178,508	5.0%	Defined
Ameriprise Bank, FSB	37	$18,379	0.0%	Defined
Columbia Threadneedle Management Ltd	144,749	$71,901,170	5.6%	Defined

NORTHERN TRUST CORP

$1,235,108,212

1.02%

2,486,478

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NORTHERN TRUST CO joint	2,006,666	$996,771,201	80.7%	Defined
NORTHERN TRUST GLOBAL INVESTMENTS LTD	369,023	$183,304,794	14.8%	Defined
Northern Trust Asset Management Australia Pty Ltd	53,099	$26,375,866	2.1%	Defined
Northern Trust Co of Hong Kong Ltd	39,363	$19,552,782	1.6%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC joint	11,378	$5,651,793	0.5%	Other
Green Century Capital Management, Inc. joint	6,700	$3,328,091	0.3%	Other
MILFAM LLC joint	249	$123,685	0.0%	Other

GOLDMAN SACHS GROUP INC

$1,232,765,138

1.02%

2,481,761

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	383,556	$190,523,771	15.5%	Defined
GOLDMAN SACHS ASSET MANAGEMENT, L.P.	2,002,102	$994,504,126	80.7%	Defined
GOLDMAN SACHS INTERNATIONAL	10,350	$5,141,155	0.4%	Defined
GOLDMAN SACHS WEALTH SERVICES, L.P.	62,220	$30,906,540	2.5%	Defined
Goldman Sachs Trust Company, N.A. joint	17,546	$8,715,624	0.7%	Defined
GOLDMAN SACHS ASSET MANAGEMENT CO., LTD.	5,987	$2,973,922	0.2%	Defined

Clearbridge Investments, LLC

$1,163,796,167

0.96%

2,342,915

VICTORY CAPITAL MANAGEMENT INC

$1,079,469,792

0.89%

2,173,152

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

$1,013,966,007

0.84%

2,041,282

Legal & General Group Plc

$928,892,550

0.77%

1,870,015

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Legal & General Investment Management America Inc	661,039	$328,357,902	35.3%	Defined
Legal & General Investment Management Ltd joint	1,208,976	$600,534,648	64.7%	Defined

PRICE T ROWE ASSOCIATES INC /MD/

$858,558,562

0.71%

1,728,421

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
T. Rowe Price International Ltd	369,768	$183,674,858	21.4%	Defined
Held directly	1,358,653	$674,883,704	78.6%	Sole

Bank of New York Mellon Corp

$830,842,010

0.69%

1,672,623

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BNY Mellon Trust of Delaware joint	2,698	$1,340,176	0.2%	Defined
Mellon Investments Corporation joint	827,953	$411,269,092	49.5%	Other
BNY Mellon Investment Adviser, Inc.	16,803	$8,346,554	1.0%	Defined
Newton Investment Management Limited joint	27,053	$13,438,036	1.6%	Defined
BNY Mellon Securities Corporation	349	$173,358	0.0%	Defined
The Bank of New York Mellon	463,220	$230,095,270	27.7%	Defined
BNY Mellon, NA joint	160,983	$79,965,083	9.6%	Defined
Walter Scott & Partners Limited	15,280	$7,590,034	0.9%	Defined
BNY Mellon Advisors, Inc. joint	75,169	$37,338,696	4.5%	Other
Newton Investment Management North America, LLC joint	82,071	$40,767,126	4.9%	Defined
Held directly	1,044	$518,585	0.1%	Defined

DEUTSCHE BANK AG\

$784,391,303

0.65%

1,579,110

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Deutsche Bank Trust Co Americas	6,066	$3,013,163	0.4%	Defined
DWS Investment GmbH	505,917	$251,304,151	32.0%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC	46,507	$23,101,422	2.9%	Defined
Deutsche Bank (Suisse) SA	358	$177,829	0.0%	Defined
DEUTSCHE BANK NATIONAL TRUST Co	2,049	$1,017,799	0.1%	Defined
Deutsche Bank Trust Co Delaware	231	$114,744	0.0%	Defined
DEUTSCHE BANK TRUST COMPANY, NATIONAL ASSOCIATION	3,551	$1,763,887	0.2%	Defined
DWS Investments UK Ltd	831,502	$413,031,988	52.7%	Defined
DBX Advisors LLC	26,398	$13,112,678	1.7%	Defined
Deutsche Bank S.p.A	2,840	$1,410,713	0.2%	Defined
DWS Investments Hong Kong Ltd	12,511	$6,214,589	0.8%	Defined
DWS International GmbH	141,090	$70,083,635	8.9%	Defined
Held directly	90	$44,705	0.0%	Defined

Amundi

$768,197,412

0.63%

1,546,509

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Amundi Asset Management joint	1,520,799	$755,426,484	98.3%	Defined
CPR Asset Management	25,710	$12,770,928	1.7%	Defined

FMR LLC

$723,814,089

0.60%

1,457,158

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC joint	455,479	$226,250,082	31.3%	Defined
FIDELITY MANAGEMENT TRUST CO	237,146	$117,797,532	16.3%	Defined
STRATEGIC ADVISERS LLC	733,153	$364,179,089	50.3%	Defined
FIAM LLC	24,875	$12,356,158	1.7%	Defined
Fidelity Diversifying Solutions LLC	6,505	$3,231,228	0.4%	Defined

VANGUARD FIDUCIARY TRUST CO

$708,033,974

0.59%

1,425,390

Jupiter Topco LLC

$625,878,307

0.52%

1,259,997

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JANUS HENDERSON INVESTORS UK Ltd	54,178	$26,911,837	4.3%	Defined
JANUS HENDERSON INVESTORS US LLC	1,130,695	$561,650,127	89.7%	Defined
Janus Henderson Investors (Jersey) Ltd	50,371	$25,020,786	4.0%	Defined
Held directly	24,753	$12,295,557	2.0%	Defined

DIMENSIONAL FUND ADVISORS LP

$580,655,511

0.48%

1,168,956

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Dimensional Fund Advisors Ltd.	14,856	$7,379,420	1.3%	Defined
DFA Australia Ltd.	95,204	$47,290,682	8.1%	Defined
Dimensional Fund Advisors Pte. Ltd.	3,154	$1,566,686	0.3%	Defined
Dimensional Ireland Ltd	91,440	$45,420,991	7.8%	Defined
Held directly	964,302	$478,997,732	82.5%	Sole

WCM INVESTMENT MANAGEMENT, LLC

$572,279,652

0.47%

1,152,094

Nuveen, LLC

$537,305,388

0.44%

1,081,685

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Nuveen Asset Management, LLC joint	42,073	$20,898,920	3.9%	Defined
TIAA CREF INVESTMENT MANAGEMENT LLC joint	482,584	$239,713,950	44.6%	Defined
TEACHERS ADVISORS, LLC joint	557,028	$276,692,518	51.5%	Defined

ROYAL BANK OF CANADA

$486,924,048

0.40%

980,259

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RBC Global Asset Management Inc.	239,684	$119,058,233	24.5%	Defined
RBC CMA LTD.	8,335	$4,140,244	0.9%	Defined
RBC Capital Markets, LLC	376,975	$187,254,791	38.5%	Defined
RBC Dominion Securities Inc.	22,537	$11,194,804	2.3%	Defined
RBC Phillips, Hager & North Investment Counsel Inc.	48	$23,843	0.0%	Defined
RBC Private Counsel (USA) Inc.	196	$97,359	0.0%	Defined
RBC Trust Co (Delaware) Ltd	1,883	$935,342	0.2%	Defined
CITY NATIONAL BANK	77,495	$38,494,090	7.9%	Defined
RBC Rochdale, LLC	67,977	$33,766,215	6.9%	Defined
BREWIN DOLPHIN WEALTH MANAGEMENT LTD	801	$397,880	0.1%	Defined
Held directly	184,328	$91,561,247	18.8%	Sole

BNP PARIBAS ASSET MANAGEMENT Holding S.A.

$446,010,389

0.37%

897,893

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BNP PARIBAS ASSET MANAGEMENT Europe	369,928	$183,754,335	41.2%	Defined
BNP Paribas Asset Management USA, Inc.	243,217	$120,813,180	27.1%	Defined
AXA INVESTMENT MANAGERS UK LIMITED	284,748	$141,442,874	31.7%	Defined

Assenagon Asset Management S.A.

$377,298,225

0.31%

759,564

WELLS FARGO & COMPANY/MN

$372,313,040

0.31%

749,528

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLS FARGO BANK N A	83,943	$41,697,006	11.2%	Defined
WELLS FARGO ADVISORS FINANCIAL NETWORK, LLC	131,039	$65,091,002	17.5%	Defined
WELLS FARGO CLEARING SERVICES, LLC	443,104	$220,103,049	59.1%	Defined
Wells Fargo Securities, LLC	18,904	$9,390,183	2.5%	Defined
WELLS FARGO INVESTMENT INSTITUTE, INC.	72,538	$36,031,800	9.7%	Defined

ARROWSTREET CAPITAL, LIMITED PARTNERSHIP

$366,774,503

0.30%

738,378

BARCLAYS PLC

$364,239,192

0.30%

733,274

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BARCLAYS BANK PLC	592,476	$294,300,603	80.8%	Defined
BARCLAYS CAPITAL INC.	4,107	$2,040,070	0.6%	Defined
BARCLAYS CAPITAL SECURITIES LTD	103,157	$51,241,176	14.1%	Defined
Barclays Capital Luxembourg SaRL	32,247	$16,018,052	4.4%	Defined
Barclays Investment Solutions Ltd	1,287	$639,291	0.2%	Defined

Swiss National Bank

$356,373,971

0.29%

717,440

UBS Group AG

$353,800,411

0.29%

712,259

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Financial Services Inc	273,133	$135,673,355	38.3%	Defined
UBS AG	397,934	$197,665,755	55.9%	Defined
UBS Switzerland AG	20,109	$9,988,743	2.8%	Defined
UBS Europe SE	9,200	$4,569,916	1.3%	Defined
UBS Bank (Canada)	11,777	$5,849,989	1.7%	Defined
UBS Brasil Administradora de Valores Mobiliarios Ltda	106	$52,653	0.0%	Defined

CITIGROUP INC

$351,172,214

0.29%

706,968

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citibank, N.A. joint	43,637	$21,675,807	6.2%	Defined
Citigroup Financial Products Inc. joint	663,331	$329,496,407	93.8%	Defined

HSBC HOLDINGS PLC

$335,912,169

0.28%

676,247

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
HSBC Bank USA, N.A.	105,887	$52,597,249	15.7%	Defined
HSBC Global Asset Management (Hong Kong) Ltd	121	$60,104	0.0%	Defined
HSBC Global Asset Management (UK) Ltd	484,862	$240,845,501	71.7%	Defined
HSBC GLOBAL ASSET MANAGEMENT (FRANCE)	9,144	$4,542,099	1.4%	Defined
HSBC Trinkaus & Burkhardt AG, Germany	1,880	$933,852	0.3%	Defined
Hang Seng Investment Management Ltd	742	$368,573	0.1%	Defined
HSBC PRIVATE BANK (SUISSE) LTD	69	$34,274	0.0%	Defined
Hongkong & Shanghai Banking Corp Ltd / ASP	1,385	$687,971	0.2%	Defined
HSBC BANK PLC	72,029	$35,778,965	10.7%	Defined
HSBC SECURITIES USA INC	3	$1,490	0.0%	Defined
Held directly	125	$62,091	0.0%	Defined

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$334,945,039

0.28%

674,300

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	674,300	$334,945,039	100.0%	Other

Mitsubishi UFJ Asset Management Co., Ltd.

$321,480,178

0.27%

647,193

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MITSUBISHI UFJ FINANCIAL GROUP INC	647,193	$321,480,178	100.0%	Defined

AQR CAPITAL MANAGEMENT LLC

$306,070,117

0.25%

616,170

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Petros Family Wealth, LLC	71	$35,267	0.0%	Other
KEB ASSET MANAGEMENT, LLC	67	$33,280	0.0%	Other
RF&L WEALTH MANAGEMENT, LLC	8	$3,973	0.0%	Other
Prism Planning Partners LLC	102	$50,666	0.0%	Other
Compound Planning, Inc.	21	$10,431	0.0%	Other
Arax Advisory Partners	1,552	$770,924	0.3%	Other
HALBERT HARGROVE GLOBAL ADVISORS, LLC	1,208	$600,049	0.2%	Other
Stokes Family Office, LLC	130	$64,574	0.0%	Other
NATIONAL MUTUAL FUNDS MANAGEMENT LTD	16,795	$8,342,580	2.7%	Other
Held directly	596,216	$296,158,373	96.8%	Defined

Sumitomo Mitsui Trust Group, Inc.

$303,952,564

0.25%

611,907

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUMITOMO MITSUI TRUST BANK Ltd	611,907	$303,952,564	100.0%	Defined

AMERICAN CENTURY COMPANIES INC

$288,550,953

0.24%

580,901

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
AMERICAN CENTURY INVESTMENT MANAGEMENT INC	580,901	$288,550,953	100.0%	Defined

Bellevue Group AG

$287,424,866

0.24%

578,634

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BB Biotech AG joint	557,375	$276,864,883	96.3%	Defined
Bellevue Asset Management AG	21,259	$10,559,983	3.7%	Defined

NEUBERGER BERMAN GROUP LLC

$277,893,114

0.23%

559,445

RAYMOND JAMES FINANCIAL INC

$276,617,014

0.23%

556,876

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RAYMOND JAMES & ASSOCIATES	500,385	$248,556,241	89.9%	Defined
Raymond James Financial Services Advisors, Inc.	48,539	$24,110,777	8.7%	Defined
EAGLE ASSET MANAGEMENT INC	961	$477,357	0.2%	Defined
RAYMOND JAMES TRUST N.A.	6,991	$3,472,639	1.3%	Defined

MANUFACTURERS LIFE INSURANCE COMPANY, THE

$275,230,642

0.23%

554,085

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MANULIFE FINANCIAL CORP joint	554,085	$275,230,642	100.0%	Defined

Vanguard Global Advisers, LLC

$271,941,295

0.22%

547,463

MARSHALL WACE, LLP

$270,169,956

0.22%

543,897

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Marshall Wace North America L.P. joint	543,897	$270,169,956	100.0%	Other

National Pension Service

$268,000,736

0.22%

539,530

Pictet Asset Management Holding SA

$267,864,136

0.22%

539,255

EDGEWOOD MANAGEMENT LLC

$263,765,120

0.22%

531,003

SG Americas Securities, LLC

$260,147,435

0.22%

523,720

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$255,915,296

0.21%

515,200

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	515,200	$255,915,296	100.0%	Other

Life Cycle Investment Partners Ltd

$255,408,134

0.21%

514,179

CITADEL ADVISORS LLC

$253,545,893

0.21%

510,430

VOYA INVESTMENT MANAGEMENT LLC

$250,957,432

0.21%

505,219

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Voya Investment Management Co. LLC joint	505,219	$250,957,432	100.0%	Defined

VANGUARD ASSET MANAGEMENT, Ltd

$245,477,011

0.20%

494,186

ENVESTNET ASSET MANAGEMENT INC

$242,218,959

0.20%

487,627

MILLENNIUM MANAGEMENT LLC

$232,673,299

0.19%

468,410

NATIXIS ADVISORS, LLC

$222,848,476

0.18%

448,631

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Loomis, Sayles & Company, L.P.	15,292	$7,595,995	3.4%	Other
Vaughn Nelson Investment Management, L.P.	0	$0	0.0%	Other
Natixis Investment Managers, L.P.	433,339	$215,252,481	96.6%	Defined

California Public Employees Retirement System

$222,286,178

0.18%

447,499

BANK OF MONTREAL /CAN/

$212,326,240

0.18%

427,448

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BMO Asset Management Inc.	156,387	$77,682,114	36.6%	Defined
BMO Bank N.A.	82,445	$40,952,904	19.3%	Defined
BMO Delaware Trust Co	987	$490,272	0.2%	Defined
BMO Family Office, LLC	7,090	$3,521,815	1.7%	Defined
BMO NESBITT BURNS INC.	36,411	$18,086,436	8.5%	Defined
BMO PRIVATE INVESTMENT COUNSEL INC.	55,881	$27,757,769	13.1%	Defined
BMO NESBITT BURNS SECURITIES LTD.	1,630	$809,669	0.4%	Defined
Stoker Ostler Wealth Advisors, Inc.	16,826	$8,357,978	3.9%	Defined
Held directly	69,791	$34,667,283	16.3%	Defined

MASSACHUSETTS FINANCIAL SERVICES CO /MA/

$210,141,127

0.17%

423,049

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MFS Institutional Advisors, Inc.	8,874	$4,407,982	2.1%	Defined
MFS Investment Management CO (LUX) S.A.R.L.	1,635	$812,153	0.4%	Defined
MFS International (U.K.) Ltd.	15,372	$7,635,733	3.6%	Defined
MFS Heritage Trust CO	7,066	$3,509,894	1.7%	Defined
MFS INVESTMENT MANAGEMENT CANADA LTD	33,892	$16,835,173	8.0%	Defined
MFS International Australia Pty Ltd	324	$160,940	0.1%	Defined
Held directly	355,886	$176,779,252	84.1%	Sole

Chevy Chase Trust Holdings, LLC

$201,822,888

0.17%

406,303

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
CHEVY CHASE TRUST Co	402,313	$199,840,936	99.0%	Defined
ASB CAPITAL MANAGEMENT LLC	3,990	$1,981,952	1.0%	Defined

Robeco Institutional Asset Management B.V.

$200,875,625

0.17%

404,396

RHUMBLINE ADVISERS

$196,893,837

0.16%

396,380

ADAGE CAPITAL PARTNERS GP, L.L.C.

$195,693,737

0.16%

393,964

Hudson Bay Capital Management LP

$193,943,261

0.16%

390,440

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Hudson Bay Capital UK LLP	3,440	$1,708,751	0.9%	Defined
Held directly	387,000	$192,234,510	99.1%	Sole

PRINCIPAL FINANCIAL GROUP INC

$193,481,798

0.16%

389,511

CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM

$190,491,484

0.16%

383,491

Zurcher Kantonalbank (Zurich Cantonalbank)

$189,135,908

0.16%

380,762

DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main

$178,490,982

0.15%

359,332

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DZ PRIVATBANK AG joint	1,180	$586,141	0.3%	Defined
UNION ASSET MANAGEMENT HOLDING AG joint	357,787	$177,723,535	99.6%	Defined
Held directly	365	$181,306	0.1%	Sole

CANADA PENSION PLAN INVESTMENT BOARD

$176,379,881

0.15%

355,082

Russell Investments Group, Ltd.

$167,393,033

0.14%

336,990

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Russell Investment Management Limited	17,765	$8,824,408	5.3%	Defined
Russell Investment Management, LLC	157,730	$78,349,222	46.8%	Defined
Russell Investments Canada Limited	10,145	$5,039,325	3.0%	Defined
Russell Investments Capital, LLC joint	35,959	$17,861,912	10.7%	Defined
Russell Investments Implementation Services, LLC	17,577	$8,731,023	5.2%	Defined
Russell Investments Ireland Limited joint	14,235	$7,070,951	4.2%	Other
Russell Investments Japan Co., LTD. joint	5,005	$2,486,133	1.5%	Defined
Russell Investments Limited joint	63,121	$31,354,092	18.7%	Other
Russell Investments Trust Company joint	15,453	$7,675,967	4.6%	Other

Universal- Beteiligungs- und Servicegesellschaft mbH

$160,817,330

0.13%

323,752

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Universal-Investment-Gesellschaft mbH joint	323,752	$160,817,330	100.0%	Defined

RENAISSANCE TECHNOLOGIES LLC

$158,957,573

0.13%

320,008

Bank Julius Baer & Co. Ltd, Zurich

$158,641,156

0.13%

319,371

AMF Tjanstepension AB

$156,353,218

0.13%

314,765

FIRST TRUST ADVISORS LP

$143,643,884

0.12%

289,179

LPL Financial LLC

$143,610,107

0.12%

289,111

ProShare Advisors LLC

$142,982,240

0.12%

287,847

TWO SIGMA INVESTMENTS, LP

$141,568,050

0.12%

285,000

Swedbank AB

$140,298,407

0.12%

282,444

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Swedbank Robur Fonder AB	282,440	$140,296,421	100.0%	Defined
Held directly	4	$1,986	0.0%	Sole

NEW YORK STATE COMMON RETIREMENT FUND

$137,899,202

0.11%

277,614

BAILLIE GIFFORD & CO

$135,389,224

0.11%

272,561

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BAILLIE GIFFORD & CO LTD	76,263	$37,882,119	28.0%	Defined
BAILLIE GIFFORD OVERSEAS LTD	38,785	$19,265,673	14.2%	Defined
Baillie Gifford Investment Management (Europe) Ltd	72,722	$36,123,199	26.7%	Defined
Held directly	84,791	$42,118,233	31.1%	Sole

BNP PARIBAS ARBITRAGE, SA

$130,271,416

0.11%

262,258

Cerity Partners LLC

$127,100,291

0.11%

255,874

PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO

$124,276,381

0.10%

250,189

Hudson Bay Capital Management LP

$124,182,500

0.10%

250,000

Nykredit A/S

$123,222,817

0.10%

248,068

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Nykredit Bank A/S joint	248,068	$123,222,817	100.0%	Defined

CITADEL ADVISORS LLC

$121,500,158

0.10%

244,600

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	244,600	$121,500,158	100.0%	Defined

Key facts CIK 875320 CUSIP 92532F100 13F (30d) 934 filings 883 filers Visit website Investor relations