Ladies and gentlemen, thank you for standing by. Welcome to the Royalty Pharma First Quarter Earnings Conference Call. I would now like to turn the call over to George Grofik, Senior Vice President and Head of Investor Relations and Communications. Please go ahead, sir.

Good morning and good afternoon to everyone on the call. Thank you for joining us to review Royalty Pharma’s first quarter 2025 results. You can find the press release with our earnings results and slides for this call on the Investors page of our website at royaltypharma.com. Moving to Slide 3, I would like to remind you that the information presented in this call contains forward-looking statements that involve known and unknown risks, uncertainties, and other factors that may cause actual results to differ materially from the statements. We refer you to our most recent 10-K on file with the SEC for a description of these risks. All forward-looking statements are based on information currently available to Royalty Pharma, and we assume no obligation to update any such forward-looking statements. Non-GAAP liquidity measures will be used to help you understand our financial results, and the reconciliation of these measures to our GAAP financials is provided in the earnings press release available on our website. And with that, please advance to Slide 4. Our speakers on the call today are Pablo Legorreta, Founder and Chief Executive Officer; Marshall Urist, EVP, Head of Research and Investment; and Terry Coyne, EVP, Chief Financial Officer. Pablo will discuss the key highlights, after which Marshall will provide a portfolio update, and Terry will review the financials. Following concluding remarks from Pablo, we will hold a Q&A session in which we will be joined by Chris Hite, EVP, Vice Chairman. And with that, I’d like to turn the call over to Pablo.

Thank you, George, and welcome to everyone on the call. I am happy to report a successful start to 2025 as we execute against our vision to be the leading partner funding innovation in life sciences. Moving to Slide 6, we delivered excellent financial performance in the first quarter while continuing to expand our portfolio and returning substantial capital to shareholders. In terms of the financials, we delivered 12% growth in Royalty Receipts. This represents a recurring cash flow, and the strong performance in the quarter reflects the quality of our diversified portfolio. Milestones and other contractual receipts, which are more variable and included a larger payment this quarter, lifted growth in Portfolio Receipts our top line to 17%. Turning to capital allocation, in January we announced an evolution to a more dynamic capital allocation framework. This flexible framework allows us to scale our efforts to address the discount of our share price to intrinsic value while also pursuing attractive royalty acquisitions. At that time, we also announced our intention to repurchase up to $2 billion of shares in 2025, depending on market conditions, out of an authorized total of $3 billion. Consistent with this, we repurchased $723 million of our shares in the first quarter. At the same time, we deployed capital of just over $100 million on value-creating royalty transactions, and we increased our dividends in line with our commitment to mid-single-digit growth. Looking at our portfolio, we expanded our development stage pipeline through a new Phase 3 R&D funding collaboration with Biogen for litifilimab in lupus. As Marshall will discuss, this is a potential blood pressure therapy in a disease space with unmet patient needs, and we are excited to add this to our portfolio. We also received encouraging regulatory and clinical news on several portfolio therapies, including FDA and EC approval of Tremfya for Crohn’s and EC approval in ulcerative colitis, positive Phase 3 results for ecopipam in Tourette’s syndrome, and confirmation that Roche is advancing trontinemab into Phase 3 in Alzheimer’s disease. Lastly, I’m pleased to raise our 2025 full-year guidance. We now expect Portfolio Receipts to be between $2.975 billion and $3.125 billion, based on expected growth in Portfolio Receipts of around 6% to 12%. This guidance increase is driven by the strength of our diversified portfolio and a tailwind from a weakening U.S. dollar. Consistent with our standard practice, our guidance is based on our current portfolio and does not include the benefit of any future transactions. Slide 7 shows our impressive track record of average double-digit growth since our IPO. As I noted earlier, we delivered 12% growth in Royalty Receipts in the first quarter. This is at the high end of the run rate included in our full-year guidance and sets us up well to deliver another successful result in 2025. Overall, our track record underscores our ability to execute successfully and consistently against our strategy in the growing market for biopharma royalties. With that, I will hand it over to Marshall.

Thanks, Pablo. I want to focus today on some exciting updates to our development stage portfolio. First, the R&D funding partnership we recently announced with Biogen, and second, the encouraging Phase 3 results with ecopipam in Tourette’s syndrome. As Pablo mentioned, we were also excited to see Roche advance trontinemab to Phase 3 for Alzheimer’s disease, where we could receive a royalty averaging in the mid-single digits. Beginning with litifilimab, this is a potential first-in-class medicine currently in Phase 3 development by Biogen for two types of lupus, systemic lupus erythematosus and cutaneous lupus. Phase 3 results are expected in 2026 and 2027, so relatively near-term. Importantly for our shareholders, this partnership fits clearly within our product selection and capital allocation framework with an attractive risk-reward profile given compelling Phase 2 data that was published in the New England Journal of Medicine with blockbuster commercial potential in Biogen’s capable hands. In terms of financials, we will provide Biogen with R&D funding of up to $250 million over six quarters to support the advancement of litifilimab in return for a mid-single-digit royalty and milestone. Slide 10 highlights why we are so excited by litifilimab’s commercial potential. There are 600,000 people living with lupus in the U.S. and greater than 3 million patients globally. Yet today, only two biologics are currently approved to treat systemic lupus erythematosus, and there are no biologics specifically approved for cutaneous lupus. Together, the two approved biologics reported around $2.4 billion in combined sales last year, so already a blockbuster market. However, we expect many more lupus patients will benefit from advanced therapies in the years to come. Our internal analyses show only about 10% of U.S. lupus patients currently receive biologics. When we compare this to more mature immunology markets like inflammatory bowel disease, psoriasis and rheumatoid arthritis, biologic penetration reaches 40% to 60%, so the lupus market has significant room for growth. This will be driven by medical guidelines that are shifting to support earlier stage use of biologics for lupus and the introduction of new options like litifilimab. To summarize, we think litifilimab has the potential to significantly improve outcomes for people living with lupus. It’s an exciting blockbuster opportunity and a great addition to our development stage pipeline. On Slide 11, I want to highlight the positive Phase 3 results that were recently reported for ecopipam in Tourette’s syndrome. Ecopipam is a first-in-class potential therapy with a novel mechanism of action which we believe has a high probability of clinical and commercial success. As ecopipam is being developed by Emalex Biosciences, a private company, many of you might have missed this positive development. As a reminder, we acquired a royalty interest in ecopipam at the start of 2024 for an upfront payment of $49 million and up to $44 million in contingent regulatory milestones. In return, we are entitled to meaningful tiered royalties of 6% to 10%. In February of this year, Emalex reported positive topline Phase 3 data. The study showed a clinically and statistically significant benefit for ecopipam in maintaining reductions of the focal and motor tics that characterize Tourette’s syndrome as compared to placebo. The results were consistent across pediatric and adult patients. And in terms of safety, ecopipam was generally well-tolerated consistent with earlier clinical studies. Based on these results, Emalex plans to meet with the FDA and other global regulators to discuss the submission of a new drug application later this year. Turning to the opportunity for ecopipam, we believe it addresses a clear unmet need. There has not been a new option for Tourette’s in over a decade, and it could be the first drug ever exclusively developed for Tourette’s. Our proprietary analytics support a large Tourette’s syndrome population with over 120,000 diagnosed U.S. patients, yet only half currently receive medical therapy, suggesting that new treatments like ecopipam could expand the market. All told, we believe ecopipam can improve the lives of Tourette’s patients and represent a meaningful commercial opportunity where we hold a sizable 6% to 10% royalty. With that, I’d like to hand it over to Terry.

Thanks, Marshall. Let’s move to Slide 14. This slide shows how our efficient business model generates substantial cash flow to be reinvested. As you heard from Pablo, Royalty Receipts grew by 12% in the first quarter, reflecting the strength of our diversified portfolio. The key drivers of growth were the strong performance of the cystic fibrosis franchise, Trelegy and Xtandi, and the 2024 acquisition of royalties on Voranigo. Income from milestones and other contractual receipts amounted to $51 million and included a $27 million milestone payment on Airsupra. As a consequence, Portfolio Receipts, our top line, grew by 17% to $839 million. As we move down the column, operating and professional costs equated to 12.1% of Portfolio Receipts. This included $33 million of one-time payments related to the sale of the MorphoSys Development Funding Bonds. Notably, the $511 million of proceeds we received were accounted for as an asset sale and were not included in Portfolio Receipts. Excluding this item, the ratio would have been just over 8% of Portfolio Receipts, which is very typical for our business. Net interest paid of $127 million reflected the semi-annual timing of our interest payment schedule with payments in the first and third quarters. For the first time, it included interest on the $1.5 billion of incremental debt that we raised in June of 2024. Moving further down the column, we’ve consistently stated that when we think of the cash generated by the business to then be redeployed into value-enhancing royalties, we look to portfolio cash flow, which is adjusted EBITDA less net interest paid. This amounted to $611 million in the quarter, equivalent to a margin of around 73%. Keeping in mind the one-time expense item I mentioned, this reflects a high level of cash conversion and once again underscores the efficiency of our business model. Lastly, on this slide, capital deployment in the first quarter was $101 million and share repurchases reduced our weighted average share count by 19 million shares as compared to the prior year period. Slide 15 provides more detail on the evolution of Royalty Receipts versus milestones and other contractual receipts in the quarter. As I highlighted earlier, Portfolio Receipts are top line, so I’ll benefit from milestone payments compared with the same period last year. Meanwhile, Royalty Receipts, which we consider our recurring cash inflows, grew by 12%, driven entirely by the underlying strength of our diversified portfolio. Slide 16 shows that we continue to maintain significant financial capacity to execute our strategy through a combination of cash from our balance sheet to cash our business generates and access to the debt markets. At the end of the first quarter, we had cash in equivalence of close to $1.1 billion. As a reminder, we received $511 million in upfront cash in January from the sale of MorphoSys Development Funding Bonds. This not only delivered an attractive IRR net investment of approximately 25%, but also helped to bolster our balance sheet and increase our financial flexibility. In terms of our borrowing position, we have investment-grade debt outstanding of $7.8 billion. Our leverage now spans at around 3 times total debt-to-EBITDA or 2.5 times the net of cash in equivalence. We also have undrawn financial capacity from our $1.8 billion revolver. We were also pleased that Moody’s upgraded our credit rating to Baa2 from Baa3. As Pablo noted, under our dynamic capital allocation framework, we took advantage of the fundamental disconnect in our share price and repurchased $723 million in the quarter. Slide 17 lays out our dynamic capital allocation framework. This framework balances our view of the share price valuation against the attractiveness of royalty deals. When our share price is trading at a discount to its intrinsic value, share buybacks will be an important part of our capital allocation. Conversely, when our shares approach a premium to intrinsic value, we would plan to dial back our share repurchases and focus on higher returning royalty deals. In an environment where neither attractive royalty deals nor share repurchases are available, we have other options available for our cash, including growing cash to wait for the right deals, paying down debt, or increasing dividend distribution. Ultimately, we are focused on driving shareholder value through allocating capital as efficiently and effectively as possible. So far this year, we’ve been operating in the upper left quadrant, where we see many attractive royalty opportunities and a discount to the intrinsic value of our stock. For this reason, we have accelerated the rate of share repurchases, consistent with our target of up to $2 billion in 2025, while also increasing our dividend and continuing to deploy capital on attractive royalty deals. In total, we returned $850 million to shareholders in the first quarter, a record for Royalty Pharma, while we maintain a very active and robust deal pipeline. On Slide 18, we are raising our full-year 2025 financial guidance. We expect Portfolio Receipts to be in the range of $2.975 billion to $3.125 billion, which is a $75 million increase versus prior year guidance. About half the increase was driven by the strength of our diversified portfolio, while the other half was driven by the weakening of the U.S. dollar. Starting with Portfolio Receipts, we are expecting growth of around 6% to 12%, which reflects the momentum of our portfolio. This takes into account a range of scenarios for the launch of Alyftrek, the new Vertex triple, as well as for Promacta generics, biosimilar Tysabri and the impact of Medicare Part D redesign. Milestones and other contractual receipts are expected to increase from $31 million in 2024 to approximately $60 million in 2025. Importantly, and consistent with our standard practice, this guidance is based on our portfolio as of today and does not take into account the benefit of any future royalty acquisitions. For modeling purposes, we would remind you that several of our largest royalties, such as the cystic fibrosis franchise, Trelegy, Evrysdi, and others are cured royalties, which means they reset to a lower rate in the first quarter. As our Royalty Receipts lag reported product sales by the marketers by one quarter, this has the effect of decreasing royalties sequentially in the second quarter. Given these dynamics, we are providing guidance for second quarter Portfolio Receipts, which we expect to be between $700 million and $725 million, representing growth of 15% to 19% compared to last year’s second quarter. Turning to expenses, payments for operating and professional costs are expected to be approximately 10% of Portfolio Receipts in 2025. This reflects a combination of our efficient business model and the one-time fee I referred to earlier related to MorphoSys Development Funding Bonds sales. You should also note that our guidance for this line does not take into account the benefit of the internalization transaction. We will provide an update after it closes. Interest paid in 2025 is expected to be around $260 million, with the minimum amounts due in Q2 and Q4. This guidance does not take into account interest received on our cash balance, which was $12 million in the first quarter. It also does not reflect the additional interest expense related to the internalization transaction. Before handing the call to Pablo, given investor interest in the current macro environment, I would like to briefly comment on tariffs as it relates to our business. In short, we do not currently expect any meaningful impact on our royalties from tariffs as we would expect potential tariffs to be paid upstream of our royalty. For example, when components of a pharmaceutical product are manufactured outside of the U.S., the non-U.S. typically sells to an affiliated U.S. company. This sale or import into the U.S. triggers the tariff. The affiliate of the marketer then sells the product to a third party. Our royalties are calculated on the sale to the third party. As such, the tariff-bearing import of the product occurs upstream of the royalty-bearing sale. To close, we have had a great start to the year, and we expect to deliver another full year of strong financial performance in 2025. With that, I would like to turn the call over to Pablo.

Thanks, Terry. Let me begin my concluding remarks by saying how pleased I am with our performance so far in 2025. We delivered double-digit growth, we strengthened our exciting development stage pipeline, and our dynamic capital allocation framework allowed us to buy back stock at an attractive price for our shareholders. We also announced the acquisition of our external manager, which we expect to deliver multiple benefits for shareholders and we’re on track to close the transaction in the current quarter. On my final slide, I want to share my excitement for our upcoming Investor Day on September 11th in New York City. My team and I are looking forward to providing an update on our plans to drive shareholder value creation through leveraging our unique business model and capabilities in the large and growing market for funding biopharma innovation. We think it’s a compelling story, and we hope you will be able to join us. With that, we will be happy to take your questions.

Thank you, Pablo. I will now open up the call to your questions. Operator, please take the first question.

Thank you. Our first question comes from Chris Schott with JPMorgan. Your line is open.

Hey. This is Hardik Parikh at JPMorgan in for Chris Schott. I just wanted to ask about the investment environment and opportunities. How have the regulatory and policy uncertainties of late impacted the deal-making environment from your side in terms of the assets you consider or how you evaluate risk? And then just a second part is just any updates in terms of the Vertex cystic fibrosis portfolio negotiations in terms of the arbitration timeline? Thank you.

Yes. Thanks for your question. Chris, why don’t you take the first one, and then Terry can talk about the CF situation.

Sure. Thanks for the question. The pipeline remains very robust. We, as a reminder, have invested about $12 billion deployed since our IPO, and we’ve announced transactions of over $15 billion. And our in-depth reviews have gone up significantly since 2019, almost 150%. So the environment is very strong for alternative forms of capital, and that remains true through the first quarter. Obviously, there’s a lot of policy uncertainty, but that’s not really impacting our opportunity set, and we think that’s going to show through for the remainder of the year.

And then on Vertex, we have no update at this time, and we continue to feel very strongly about our position that deuterated Kalydeco is the same as Kalydeco, but there is no update at this point on any potential arbitration.

Thank you. Operator, next question, please. Our next question comes from Mike Nedelcovych with TD Cowen. Your line is open.

Thank you for the questions. I have one follow-up and then two questions. So my first follow-up actually relates to tariffs. It sounds like there’s no way that the accounting for tariffs could directly affect the royalties owed to Royalty Pharma, but are you aware of any methods that pharma may use to offset tariffs that could impact royalties? And maybe that would be either positive or negative. And then my first question relates again to the policy environment. You noted policy uncertainty. It seems as though that could present a potential opportunity to Royalty Pharma, particularly in academia and non-profits as well. The need for alternative sources of funding has quickly become urgent. Is this an area where Royalty Pharma could step in in a way it hasn’t in the past? And then my last question is a product-related one on ecopipam. You lay out a very nice rationale and outlook for this agent in Tourette’s. Given the opportunity, why do you think that this indication and possibly even this product is not being pursued by larger pharma companies, at least so far, in any visible way? Thank you.

Sure. Thank you for the question. I'll begin by discussing your inquiry about policy and how it might be advantageous for Royalty Pharma. Terry will then address the question on tariffs, and Marshall will cover the topic on Tourette’s. Regarding policy, you are correct in mentioning the considerable concern over the proposed cuts to NIH funding. The Trump administration has recently suggested a reduction of about $20 billion from $47 billion to $27 billion in their budget proposal. I believe this is more of a negotiating stance with Congress, and in the end, the cuts may not be as drastic as proposed. I just returned from the Milken conference, where there were extensive discussions about this issue, both publicly and in private sessions with the former Head of NIH and various university presidents. The consensus is that the U.S. has held a longstanding leadership role in medical research, and diminishing NIH investment could risk losing that leadership to other regions like Europe and China. Concerning market uncertainties, there are aspects that could actually benefit us. As previously mentioned, the U.S. biotech sector, which is a significant part of the R&D landscape consisting of approximately 8,000 companies globally, faces a capital requirement of about $1 trillion over the next decade to advance their pipelines through various phases to approval. Specifically, we estimate that $450 billion to $470 billion of that total will be needed in the next five years. This segment depends heavily on capital markets for funding, and the current environment poses challenges. This situation presents an appealing opportunity for Royalty Pharma to provide necessary capital to these firms. We are enthusiastic about this aspect of our business, particularly our synthetic royalty model that we developed over a decade ago, which has become a significant and expanding part of our capital strategy. I'll stop there and let Terry discuss tariffs and Marshall address Tourette’s.

Sure. On tariffs, yeah, as I mentioned in our prepared remarks, we’re in a fortunate position where we do not expect much of an impact at all on any potential tariffs, just as a result of how the supply chain typically works. In terms of tools that pharma would use, potential tools to offset tariffs, it’s really tough for us to speculate at this time. And so I think it’s just early days there. But overall, we feel very good about our business and our ability to have minimal impact from tariffs.

Mike, just quickly on your question on Tourette’s. I think taking a step back, this investment, the potential opportunity here, highlights one of the strengths of our model, which is the ability to identify underappreciated or potentially overlooked and underserved markets like Tourette’s syndrome. And I think it brings together the breadth of our platform, our ability to really dig in and do proprietary analytics to gain conviction in the market opportunity because it hasn’t, to your point, enjoyed the focus of much of the biopharma industry. So we think this is exciting, and I’m proud of the work we did here and look forward to finding more of these in the future.

Thank you, Michael. Operator, next question, please.

Our next question comes from Terence Flynn with Morgan Stanley. Your line is open.

Great. Good morning. Thanks for taking the questions. Two product ones for me. Obviously, it’s still early days on the Alyftrek launch, but Terry, you mentioned that your guidance contemplates a range of scenarios. So just wondering where this initial quarter falls relative to your expectations, if you could elaborate at all there. And then the second one is Camzyos received a less restrictive REMS from the FDA, as I know you’re aware. Just thoughts on that ahead of an aficamten FDA decision and launch there and how important it is or maybe less important now in terms of differentiation on the REMS side as you guys thought about the opportunity for aficamten? Thank you.

Sure. On Alyftrek, it’s still very early days here, and we’ve obviously been following it closely. We looked at a number of different scenarios when we were thinking about this year and also the long term. But I think the big picture for us is that we continue to expect under any outcome related to royalty rates that the Vertex cystic fibrosis franchise will continue to be a major contributor to our top line over the long term. I think that’s a function of the amazing data and the amazing experience that patients have had with Trikafta and the strength of that product and brand. I think that no matter what happens, we continue to feel really good about our position on the CF franchise.

Terence, good morning. I want to quickly discuss the aficamten opportunity. We are really excited about its potential and are glad to include it in our portfolio. Regarding the REMS updates, we initially considered this scenario and thought it was a likely outcome as both the market and regulators gained more experience with the safety profile. Over the years, our investments have shown multiple precedents of this happening, sometimes quickly and sometimes slowly. Therefore, we always expected this could be a possibility. Our core thesis remains that the hypertrophic cardiomyopathy market has significant potential and can accommodate more than one product. We continue to appreciate aficamten’s profile and believe the Cytokinetics team will manage it effectively.

Thank you. Operator, next question, please.

Our next question comes from Geoff Meacham with Citi. Your line is open.

Great. Good morning, everyone. Thank you for the question. I have a couple. Terry or Pablo, regarding Slide 16, share repurchases had a significant impact on the stock and were a major use of cash. Can you discuss your current position in the capital deployment cycle? I understand you can pursue both new deals and buybacks, but what influences the decision to prioritize one over the other? Additionally, for Marshall, we often inquire about how your diligence process for royalty deals evolves. It appears that recently you have focused on more first-in-class, unmet needs, and novel mechanisms, particularly with the two you highlighted today. Is this a deliberate strategy for the portfolio moving forward? Thank you.

Yes. Thanks for the question. I’ll actually ask Terry to take the question on capital allocation and then Marshall.

On capital allocation and share repurchases, it's dynamic. We were pleased to buy back a substantial amount of our stock in the first quarter at prices we find very attractive. Moving forward, we will continue to evaluate the share price in relation to intrinsic value and potential royalty opportunities. This will remain dynamic. If we continue to function effectively, as shown in the upper left quadrant on Slide 17, I believe we will maintain a balanced approach. Fortunately, we have significant financial capacity for both share repurchases and royalty acquisitions. If we believe this strategy will create the most value for shareholders, that’s the path we will take.

Geoff, regarding the second part of your question, there’s no change in our approach. Our core process focuses on identifying products to add to the portfolio that provide benefits to patients, physicians, and the system overall. We aim to be flexible in how we define those benefits. First-in-class products are important, and we prefer to invest in them; however, our fundamental principle will continue to emphasize great science, significant patient benefits, and working with a team that can maximize value. We’ve recently discussed some profiles that align with this, but overall, our core strategy remains consistent.

Okay. Thanks, guys.

Thanks, Geoff. Operator, next question, please.

Thank you. Our next question is from Jason Gerberry with Bank of America Securities. Your line is open.

Hey, guys. Thanks for taking my questions. Two for me. Just on ecopipam, I’m wondering if you can contextualize a little bit the clinical benefit in this group of patients, and do you see parallels at all to this market opportunity in, say, tardive dyskinesia, another movement disorder? I know that at one point, the VMAT2 inhibitors were being developed for Tourette’s, and just wondering, generally speaking, how to think about adoption rates and pricing at a high level if you think that TD might be a good market comp? And then on the Vertex issue, my question is really, is there any amount of time that transpires that if you did not take action, then you forgo the ability to bring a claim through dispute resolution? I’m just wondering if there’s any timeline on that. Thanks.

Sure. Marshall, why don’t you take the Tourette’s question and Terry, the CF question?

Sure, Jason, thank you for your question. Overall, I view this market as one that hasn’t seen new innovation in a long time, and the current options for adults and parents of children with Tourette’s are mostly older drugs or antipsychotics repurposed for Tourette’s. There is significant interest among physicians, patients, and parents for new treatment options. The TD market is particularly intriguing; a new treatment option could drive growth and investment, resulting in a substantial commercial opportunity. While I won’t address pricing as that's for the Emalex team to determine, we are certainly excited about this potential.

And then, Jason, on your other question, we can’t comment on the timing of any potential dispute with Vertex.

Okay. Thanks, guys.

Thank you. I’m showing no further questions. I’d like to turn the call back over to Pablo for closing remarks.

Thank you, Operator, and thank you to everyone on the call for your continued interest in Royalty Pharma. If you have any follow-up questions, please feel free to reach out to George. Thanks, everyone.

Thank you for your participation. This does conclude the program. You may now disconnect. Everyone, have a great day.