URGN · UroGen Pharma Ltd.

Transaction made pursuant to a duly adopted trading plan under Rule 10b5-1(c). The adoption date of the referenced Rule 10b5-1(c) plan is August 15, 2025. This transaction represents the final sale under such trading plan.

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $40.00 and $40.02. The reporting person undertakes to provide the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range.

The shares underlying the stock option will vest in equal quarterly installments over a period of one year, subject to the director's Continuous Service (as defined in the 2017 Equity Incentive Plan) through such vesting dates.

Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer.

The shares underlying the RSUs will vest in equal quarterly installments over a period of one year, subject to the director's Continuous Service (as defined in the 2017 Equity Incentive Plan) through such vesting dates.

Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer.

The shares underlying the RSUs will vest in equal quarterly installments over a period of one year, subject to the director's Continuous Service (as defined in the 2017 Equity Incentive Plan) through such vesting dates.

The shares underlying the stock option will vest in equal quarterly installments over a period of one year, subject to the director's Continuous Service (as defined in the 2017 Equity Incentive Plan) through such vesting dates.

The shares underlying the stock option will vest in equal quarterly installments over a period of one year, subject to the director's Continuous Service (as defined in the 2017 Equity Incentive Plan) through such vesting dates.

The shares underlying the stock option will vest in equal quarterly installments over a period of one year, subject to the director's Continuous Service (as defined in the 2017 Equity Incentive Plan) through such vesting dates.

Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer.

The shares underlying the RSUs will vest in equal quarterly installments over a period of one year, subject to the director's Continuous Service (as defined in the 2017 Equity Incentive Plan) through such vesting dates.

The shares underlying the stock option will vest in equal quarterly installments over a period of one year, subject to the director's Continuous Service (as defined in the 2017 Equity Incentive Plan) through such vesting dates.

Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer

The shares underlying the RSUs will vest in equal quarterly installments over a period of one year, subject to the director's Continuous Service (as defined in the 2017 Equity Incentive Plan) through such vesting dates.

The shares underlying the stock option will vest in equal quarterly installments over a period of one year, subject to the director's Continuous Service (as defined in the 2017 Equity Incentive Plan) through such vesting dates.

Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c). Adoption date of referenced 10b5-1(c) plan is: 08-15-2025.

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $35.00 and $35.08. The reporting person undertakes to provide the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range.

Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer.

Represents shares sold to satisfy withholding tax obligations upon the settlement of restricted stock units.

Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer.

The reporting person was granted RSUs on June 8, 2023 representing 30,000 ordinary shares. The RSUs will vest in three equal annual installments from June 8, 2024.

Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer

Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer

Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c). Adoption date of referenced 10b5-1(c) plan is: 08-15-2025.

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $30.00 and $30.05. The reporting person undertakes to provide the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range.

Represents shares sold to satisfy withholding tax obligations upon the settlement of restricted stock units.

Represents shares sold to satisfy withholding tax obligations upon the settlement of restricted stock units.

Represents shares sold to satisfy withholding tax obligations upon the settlement of restricted stock units.

Represents shares sold to satisfy withholding tax obligations upon the settlement of restricted stock units.

Represents shares sold to satisfy withholding tax obligations upon the settlement of restricted stock units.

Represents shares sold to satisfy withholding tax obligations upon the settlement of restricted stock units.

Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer.

1/3 of the shares underlying the restricted stock units will vest on each of January 31, 2027, January 31, 2028 and January 31, 2029.

Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer.

The reporting person was granted RSUs on January 31, 2024 representing 16,500 ordinary shares. The RSUs will vest in three equal annual installments from January 31, 2025.

Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer.

Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer.

The reporting person was granted RSUs on January 31, 2024 representing 10,000 ordinary shares. The RSUs will vest in three equal annual installments from January 31, 2025.

Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer.

Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer.

1/3 of the shares underlying the restricted stock units will vest on each of January 31, 2027, January 31, 2028 and January 31, 2029.

Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer.

Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer.

Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer.

The reporting person was granted RSUs on January 31, 2023 representing 10,000 ordinary shares. The RSUs will vest in three equal annual installments from January 31, 2024.

Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer.

The reporting person was granted RSUs on January 31, 2025 representing 20,000 ordinary shares. The RSUs will vest in three equal annual installments from January 31, 2026.

Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer.

The reporting person was granted RSUs on January 31, 2025 representing 10,000 ordinary shares. The RSUs will vest in three equal annual installments from January 31, 2026.

Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer.

1/3 of the shares underlying the restricted stock units will vest on each of January 31, 2027, January 31, 2028 and January 31, 2029.

Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer.

Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer.

1/3 of the shares underlying the restricted stock units will vest on each of January 31, 2027, January 31, 2028 and January 31, 2029.

Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer.

The reporting person was granted RSUs on January 31, 2023 representing 20,000 ordinary shares. The RSUs will vest in three equal annual installments from January 31, 2024.

Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer.

Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer

Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer

Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer

Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer

Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer

Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer

Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer

Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer

Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer

Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer