Volitionrx Ltd (VNRX) Q2 2026 Earnings Call Transcript

Hello, everyone, and thank you for standing by. Welcome to VolitionRx Limited's Second Quarter 2026 Earnings Conference Call. During today's presentation, all parties will be in a listen-only mode. Following the presentation, the conference call will be open for questions. If you have a question, please press the star key followed by the number 1 on your touch-tone phone. If you would like to withdraw your question, please press the star key followed by the number 2. If you're using speaker equipment, please lift the handset before making your selections. This conference call is being recorded today, August 14th, 2026. I'd now like to turn the conference call over to Louise Batchelor, Group Chief Marketing and Communications Officer. Please go ahead.

Welcome, everyone, to today's earnings conference call for VolitionRx Limited. Before we begin, I'd like to remind everyone that some of the information discussed on this conference call will include forward-looking statements covered under the Safe Harbor provisions of the Private Securities Litigation Reform Act of 1995. These statements are based on our beliefs, as well as assumptions we have used based upon information currently available to us. Because these statements reflect our current views concerning future events, these statements involve risks, uncertainties and assumptions. Actual future results may vary significantly based on a number of factors that may cause the actual results or events to be materially different from future results, performance or achievements expressed or implied by these statements. We have identified various risk factors associated with our operations in our most recent annual report on Form 10-K, quarterly reports on Form 10-Q and other filings with the Securities and Exchange Commission. We do not undertake an obligation to update any forward-looking statements made during the course of this call. Cameron Reynolds, Group Chief Executive Officer, will open the call, providing a summary of key recent achievements. and will then hand over to Terry Q's Group G Financial Officer to give a financial report before returning to Cameron, who will discuss upcoming milestones. We will then open the conference call to a question and answer session. And with that, I'll turn the call over to Cameron.

Thanks, Lou, and thank you everyone for joining Bullitian's Earnings Call today. As always, we very much appreciate your time, given the busy earnings season. We have made strong progress across all our product pillars so far in 2026. So taking each in turn, first, starting with NuQ-Nets. Subsequent to quarter end, we issued a comprehensive video update and PDF showcasing the significant scientific and clinical evidence we have amassed relating to our NuQ-Nets products and listing the extensive base of data now published. Results have consistently demonstrated that our NuQ-Nets H3.1 assay accurately distinguishes sepsis from non-infectious systemic inflammation, is highly correlated with disease severity, and provides excellent prognostic utility for outcomes such as organ failure and mortality. Moreover, NuQ-Nets provides new and additional information above standard organ failure scores, such as Apache 2 and SOFA scores. Professor Dejili Annan, one of the world's leading experts in sepsis, has stated that he believes NuQ-Nets could become a game changer in modifying a patient's trajectory and that introducing NuQ-Nets into hospitals would lead to new ways of treating sepsis, improving patient survival and the quality of life of survivors. A very powerful testament indeed. Excitingly for NuQ-Nets, we've also made incredible progress in the development and evaluation of our lateral flow prototype assay. A little over a year ago, in July of 2025, we announced the quantification of nucleosomes in whole venous blood using our lateral flow prototype assay. Then, in April of this year, we reported the technical breakthrough of being able to detect nucleosomes in capillary blood or blood from a finger prick now fast forward to earlier this week and our announcement that we have demonstrated correlation of the lateral flow tradelab assay and our established c-marked automated new q nets assay in samples of critically ill confirmed sepsis patients in the intensive care unit the ability to rapidly identify high-risk patients at the point of care by quantifying their nucleosome levels using a finger prick sample and simple lateral flow device aims to enable quicker clinical decision-making and consequently better patient outcomes. This prototype technology has the exciting potential to strengthen our product portfolio. With recent estimates indicating approximately 166 million cases of sepsis worldwide, the potential adjustable market is absolutely huge. All-cause sepsis-related deaths in 2021 represented 31.5% of total global deaths, with the highest burden of mortality in lower- and middle-income countries. This is a potential game-changer, not only in diseases where time is critical, such as sepsis, but also in significantly expanding potential use cases beyond traditional hospital infrastructure. It also creates a compelling pathway into underserved low-income countries where laboratory infrastructure may be weak or non-existent. By enabling decentralised testing, our total addressable market expands. More on weeks later, when I discuss upcoming milestones, but we have made and continue to make incredibly rapid progress in the development and evaluation of this fingerprint technology. outside of sepsis but still with nuclear nets and diseases associated with nutosis we were delighted this quarter to announce our collaboration with sysmex corporation a multi-billion dollar market capitalization company listed on the tokyo stock exchange sysmex is a global leader in the field of in vitro diagnostics for hemostasis and thrombosis among other diseases where neutrophil exterior traps, NETS, play such an important role. We have already successfully transferred our new QNETS assay onto Sysmex's platform, and we're delighted they have commenced the optimisation phase in disease associated with metosis. This collaboration is in addition to that announced last year with Werfen's Immunoassay Technology Centre, a worldwide leader in specialised diagnostics. That agreement concerns another NETS-related disease, antiphosphoric lipid syndrome, APS, and they too are making good progress. We believe that Volition's NUQ-NETS test could provide not only improved diagnostic information to aid clinical decision-making and personalised care, but could also be a low-cost test to continue to monitor a patient's condition in many NETS-related diseases. Next up, MUQ cancer, specifically MUQ lung cancer. Lung cancer is the major cause of cancer-related mortality worldwide. We believe that MUQ cancer represents a significant advancement in lung cancer patient management, offering clinicians an additional tool to enhance precision in treatment selection and monitoring. Research conducted by our long-term collaborators in Taiwan and Lyon in France demonstrated that our new cancer technology empowers clinicians to make more informed treatment decisions and provides valuable new monitoring capabilities throughout the patient journey. Several manuscripts, conference posters and presentations have already been published and subsequent to quarter end, two further papers have been made available on preprint services with a further manuscript due for submission by the NTU team in the coming weeks. This evidence provides the basis of our reimbursement submission, supported by our long-term collaborators at Hospice Civils de Lyon, one of Europe's leading cancer centres. This reimbursement is the next step on the path to the first use of MUQ in clinical practice, an exciting prospect which is called to the physician's mission, using our tests to save lives. This quarter, we participated in our first pre-submission meeting with the authorities and anticipate a follow-up meeting and ultimately a submission by the third quarter of this year. Reimbursement will be a major milestone for volition in the commercialisation and licensing of UQ in the human cancer field. And, assuming achievement, we anticipate the introduction into routine clinical use in France and then we'll set our sights on rolling it out in other countries. Staying with cancer, but moving on to CaptureSeq technology, Volition is, I believe, the first company to demonstrate the isolation analysis of greater than 99% pure circulating tumor-associated DNA. Most current liquid biopsy methods involve deep sequencing of plasma DNA and bioinformatic analysis of the data produced to identify the presence of cancer in a patient. The biggest problem facing all liquid biopsy methods worldwide is that the vast majority of the circulating DNA in blood plasma samples from cancer patients comes from healthy cells, not from the cancer. Volition's technology employs an entirely novel approach to liquid biopsy that has overcome this hurdle and produces pure cancer-associated plasma DNA sequences sets for liquid biopsy. Our clinical paper detailing this technology has been peer-reviewed and published subsequent to quarter N. The manuscript describes a new liquid biopsy chemistry for isolating CTCF DNA from plasma. Our work on CTCF-bound DNA has revealed what we believe to be an unprecedented new discovery, that there is almost no CTCF-bound DNA in healthy plasma, and almost all CTCF-bound DNA in the blood of cancer patients is therefore derived from the cancer. In the published paper, we report a new two-step method for preparing pure circulating tumor DNA data sets for cancer patients. Firstly, through physical enrichment of the sample, and secondly, through bioinformatic removal of virtually all background non-tumor cell-free DNA sequences from the DNA sequence data set. These methodological and clinical breakthroughs represent a novel liquid biopsy method for a novel class of potentially thousands of liquid biopsy sequence biomarkers. CAPTCHA-SEEK shows potential for both a multi-cancer early detection approach, either alone or in combination with other tests, and the detection of minimal residual disease, MRD. Our goal is to secure a wide range of licensing agreements in the human diagnostic space, mirroring our strategy in the VETS market and we anticipate diverse deal structures with potential for upfront and milestone payments and future recurring revenue. We are in active discussions with several large liquid biopsy and diagnostic companies to accelerate the development of our CaptureSeq technology and we are in the process of undertaking technical evaluations with potential licensors. We believe the potential use cases for CaptureSeq represent a significant commercial opportunity with a total addressable market on an annualised basis of approximately $23 billion for the human multi-cancer early detection use and should it be useful, over $13 billion for MRD use. From a NuQ vet perspective, we made solid progress with our research into the use of NuQ in cats, Most notably, with our submission for peer review, our clinical manuscript. This paper reports the high accuracy of an EQVet feline proteocybe assay in detecting lymphoma in cats, the most common cancer in the species. At 97% specificity, the assay detects 86% of feline lymphomas. This breakthrough marks the development of what we expect to be the world's first simple, affordable, blood-based liquid biopsy test for feline cancer, a significant unmet need in vet medicine. This opens up the potential for cancer screening and monitoring in cats. There are more than 60 million cats in the US alone, 25% of which are senior cats, and they're by suitable for an annual check. We believe this represents a tremendous commercial opportunity for volition. The publication of this study in a peer-reviewed journal is expected subsequently to unlock a $5 million contractual milestone payment. And we also expect to generate ongoing revenue in this large and growing market where our technology meets an unmet need. We have made incredibly quick progress from a product development perspective, given it was only in May of last year that we reported detecting nucleosomes in cats, the third species for the UQ. And with that, I'll pass over to Terry for our financial report.

Thanks very much, Cameron, and hello, everyone. I am delighted to provide a financial report for the second quarter ended 30th of June, 2026. After reporting first quarter revenue of approximately $1 million with year-on-year growth of approximately 300%, second quarter revenue performance was more subdued. We recorded approximately $0.4 million in the second quarter, broadly in line with approximately $0.4 million in the same period of 2025. This result reflected higher NewQ VET revenue, offset by lower services revenue from NewQ Discover, partly reflecting the timing and lumpy nature of project delivery. Taking the first half in total, total revenue was $1.4 million and year-on-year growth was 112%. As we have stated previously, at this early stage of commercialization, revenues remain fairly uneven and difficult to predict from one quarter to the next. And so, while we remain confident of continuing to see solid growth year over year, we will not be providing revenue guidance for 2026 at this point in time. From an expenditure perspective, total operating expenses for the quarter were $4.6 million compared to $6.7 million in the same period last year, a 32% reduction year-on-year. This reflected savings from our cost reduction program, including a 27% reduction in headcount compared to the same point in 2025. As we reported in the 10K, looking at the trend over the last two years, we now operate at significantly lower levels of expenditure. Furthermore, we have and will continue to take measures to reduce costs further in 2026. Net loss for the quarter was $7.3 million compared to $6.3 million in the same quarter in 2025. This increase was primarily due to non-cash accounting charges of approximately $3 million related to the Lind convertible notes, partially offset by the $2.1 million reduction in operating expenses noted above. Net cash used in operating activities for the quarter was $5.2 million compared with $6.3 million in the comparable 2025 quarter, reflecting the partial impact of cost savings noted above. Cash and cash equivalents at the end of the quarter totaled approximately $2.8 million compared to $1.1 million as at December 31st, 2025. Receipts in the second quarter of 2026 included approximately $1.2 million in net proceeds from our at-the-market or ATM facility and approximately $4.1 million in net proceeds from a confidentially marketed public offering of shares and warrants through Maxim Group. So to summarize the finance report, second quarter revenue was flat year-on-year, however, up 112% year-on-year for the first half of the year. Operating expenses for the second quarter were 32% lower year-on-year. Operating loss was 34% lower year-on-year for the second quarter. And we continue to work on reducing our underlying operating expenses. I will now pass over to Cameron for a look at what's to come in the second half of the year.

Thank you, Terry. Looking ahead, we have a lot of exciting milestones. zones. Starting with NuQ-Vet, in addition to the anticipated publication of the feline paper, we also anticipate further development work of the assay as we prepare to commercialise the use of NuQ in caps. From a CAPTCHA-Seq point of view, we are fast-tracking its development, conducting further studies including competing conditions and larger sample sets, and working with oncology key opinion leaders. We also anticipate additional publications and conference presentations in the coming months. And lastly, but certainly in my no means least, we look forward to completing the ongoing and indeed proposed technical evaluations with potential licensing companies. For NUQ lung cancer, our laser focus is on gaining reimbursement status for the product in France. But we also look forward to sharing emerging evidence about the use of NUQ lung cancer in identifying minimal residual disease, sharing another clinical paper from the NCU team and completing the final validation study with hospice de civos de Leon. So lots to look out for. Regarding UQNets, our recent momentum will continue into the second half of the year and beyond. We are now actively targeting NGO partnerships and strategic collaborators with companies operating in low-income countries to accelerate the commercialization and market penetration of our breakthrough lateral flow assay. Working with Professor Giselle Anan and team, we look forward not only to finalising the 1,000-plus patient RAHU study, but also starting the DETEC-STEP program planned for September. As a reminder, DETEC-STEP is a French government-sponsored real-world evaluation of early detection of sepsis, and Volusian's Nucle-Nets is the sole biomarker. The DetectSep program provides an opportunity to receive individualised or personalised care adjusted to the risk of deterioration and progression to sepsis. It is indeed a privilege to be involved in such a program and we hope that through the early identification of sepsis, lives can be saved. The quality of life of survivors can be improved and importantly, that the burden on the healthcare systems can be reduced. As a final note, to end on a high, I'm also enormously proud to announce our continued work with the world-renowned Mayo Clinic in yet another potentially significant use of our new QNET assay beyond sepsis. You may recall the publication of a study at the Mayo Clinic in the Shock Journal earlier this year. The Mayo Clinic study of 674 trauma patients demonstrated that the nucleosome levels, as measured by volitions in UQH3.1 and UQH3R8 citrulline, are elevated in people that have experienced a traumatic event and are even higher in those patients that go on to have complications from the trauma. The numbers are quite stark indeed. And some of the most compelling data that I have seen, H3.1 levels in healthy people were an average of 22.3 nanograms per mil. Those with trauma were 359.7 on average. And those that went on to get venous thromboembolism were 828.4, over 37 times the level of healthies. The identification of reliable biomarkers in trauma patients is a clinical challenge and remains an unmet need in the emergency and surgical settings. I'm absolutely delighted to confirm that we are now in the process of supplying the Mayo Clinic with an immunodiagnostic systems IDF-I10 automated analyzer, our established MUQ automated platform. As Professor Park, principal investigator and senior author of the paper says, a first step into getting the NuQ-Nets product into the Mayo Clinic's laboratories. Dr. Park is an intensive care clinician and a translational researcher and is looking to develop a trauma patient model utilising H3.1 admission. She estimates the XTNX sees approximately 2,200 trauma patients per year, she commented. These biomarkers could aid in early risk identification and may inform targeted preventive strategies in trauma care. For my part, I believe this is a significant study with clear data, not only for clinicians, patients, and their families, but also for volition. A peer-reviewed publication with the Mayo Clinic research team can only support our efforts to commercialise our new QNES products. The ICAN should be placed within the Mayo Clinic this quarter, and we very much look forward to sharing further updates in the coming months. Finally, in drawing to a close, we have developed a truly remarkable, versatile platform and are working with governments, leading hospitals, KOLs and some of the biggest diagnostic and liquid biopsy companies to make our technology available worldwide as quickly as possible. We set out 15 years ago to help save lives and improve outcomes for millions of patients worldwide and we are making huge progress towards these goals. With the first clinical use netwiminers in both early sepsis detection and lung cancer management we're about to be part of the solution through simple easy to use low-cost tests. Our vision is for our technology to be incorporated into tests that will be used first by millions and ultimately hundreds of millions of people and animals a year, with our platform licensed to a range of large diagnostic and liquid biopsy companies and governments worldwide. Combining what we believe to be groundbreaking technology with their installed base of laboratories, analysed machines and sales forces around the world will achieve the optimal outcome for us. Large companies have the resources to realise the opportunities better than volition does on its own. We anticipate that the total addressable markets, TAMs, for our technologies on an annualised basis are multi-billion dollar opportunities, not only for Volition, but for our licensing partners too. Volition has made strong progress, both clinically and commercially. We are very active with a range of potential partners and are continuing our discussions with more than a dozen of the world's leading diagnostic and liquid biopsy companies to license and commercialize our very broad IP and product portfolio. These discussions are at various stages of the negotiation process across all our different pillars. Our laser focus is on executing licensing agreements and we'll update you as they progress. Thank you for joining the call today.

We very much appreciate it. we will now take your questions operator thank you we will now be conducting a question and answer session if you would like to ask a question please press star one on your telephone keypad a confirmation tone will indicate your line is in the question queue you may press star two if you would like to remove your question from the queue for participants using speaker equipment it may be necessary to pick up your handset before pressing the star keys and our first question will come from Michael Okunich with Maxim Gru.

Hey, guys. Congrats on all the progress, and thanks so much for taking my questions today. Thank you.

Just to start off, I wanted to ask about the lateral flow-based natosis test. It's a fairly impressive performance, it seems, compared to the venous straw. But if I am interpreting correctly, it does seem like there is a little bit of a loss of diagnostic accuracy as would be expected for the format. So my question is, how might this be applied versus the CE marked central lab-based test?

Yeah, very good question, Mike, and a very good one to go through. So ultimately in, you know, in America and a lot of places, the most common test will probably be a lab test. It's easy, part of your normal blood draw, it gives you the net numbers, and it goes off as part of the normal blood work. Very helpful things like CRP which are hundreds of millions of tests per year worldwide in labs you know and I think we could certainly be more helpful than that so a huge market but if you need a question answered very quickly even a stat in the busiest hospital will take an hour you can do a finger prick test also in developing countries it's extremely helpful where they have less infrastructure as we talked about could also be useful things like Ebola you know we talked about cytokine storms in a whole lot of areas if you have a worried parent or someone who has a child that's sick you can take it at home as a pinprick so I think it greatly expands the market the correlation was 90% and if you look at the numbers from trauma for example that's extremely helpful and actually is incredibly close for two completely different formats for example I discussed the results for the trauma you know the Mayo Clinic amazing to be working with them they really think this is a great test not only where we think in sepsis and other things but in trauma which is what 40 million people a year are admitted for trauma in the in the u.s the numbers are quite stark from 22 to 800 so a 90 correlation is obviously going to be very good in all those areas um so i think that the point of care opens up it doesn't by any means replace a lab that's the easiest quickest way for most people to have the test but i think it opens up a lot of other aspects. And we're in discussions with groups to launch in developing countries, looking with large multinational organizations. And it's something which Volition could also keep a hold of. There's no way we're going to want to launch our own central lab test. That's done by Siemens and Roche and Abbott that we don't want to compete with them. However, it's something we could contract manufacture and sell quite easily. So because they correlate so well, it means it'll be much easier to get them regulatory approval once we have approval on the on the main platforms as we have with new QNets in Europe and the CE mark on the brevity machine it just makes everything easier if the two the two tests agree so well I mean they're not exactly the same but that's you know 90% correlation or their high 80s is extremely good and as good as you could expect so we're very excited it opens up all the different markets for new QNets I think it's particularly important for take-home tests and for the developing world. And that was data which is incredibly encouraging, and we're hoping to have a lot more information on rolling that out, hopefully with large international organizations in the coming months.

All right. Thank you. I appreciate the additional clarity on that.

Just to follow up, so the point of care lateral flow format, right, could this be a proof of concept and have potential for development in other areas like your new-to-cancer test or some of the other nucleosome-based tests that you're doing?

Absolutely. So what we detect is H3.1, which is the basis for, obviously, the sepsis test. But in theory, everything we develop in either humans or cancer or notosis sepsis is applicable in animals. It's applicable in all of our range of all the nucleosome assays. and you know we've got other assays for uh different things um it's certainly in concept extremely so for example you know the test which has been launched by amtech uh in the vet market could absolutely be used uh in humans or similar ones in humans um those little machines as well as lateral flow as well as the big machines for example the machine uh the japanese now have our VET test automated. That's on the Revity I10 machine, which is the same as the human machine. And, you know, we're working on cats. There's every reason to believe we'll also work on cats. So where H3.1 or other assays, you know, assays work in humans, in nets, in cancer, all of them should work in all the different use cases. And that shows, yet again, the amazing breadth of what we've developed. So it all fits together very well.

Thank you. And then just one more for me before I hop back into the queue. I wanted to ask about the feline cancer diagnostic and specifically how the lower level of specific breeding in cats could impact that screening market, since it's not like dogs where you can take specific breeds that are at greater risk of certain cancers and much more general population with cats.

Yeah, very good question. So, you know, we shorthand people often say that the cat market is the same as the dog market in size or even bigger that's a little um optimistic because i don't know if you have a task but they can be a little more cantankerous and they're not as inclined to go to the vet um so currently um there are a lot less money to be made or visits by the uh by cats and dogs to veterinary but i think that's also what vet companies are trying to um improve everyone's looking to broaden the market and make more useful tests for more animals so they're trying very hard to find reasons to bring cats into the vets and give them tests and as of today there's absolutely no no current market for any cancer test there's no cancer test out there in the feline market so what we're starting with is absolutely the start and you know in infoma the data was awesome 97 specificity 86 sensitivity i mean that's even better than it was in dogs and that was with some very world-renowned vets in different countries collecting the samples. So I don't think it's fair to say it will double the market for the reasons you mentioned. Also, there are less cat visits, but it's such a large market. There are tens of millions of eligible cats around the world. So it would potentially be a very lucrative market, and they do tend to live longer than dogs, so there's a time period. So it's all something we're working on, But I think any way which you slice and dice it, it's millions or tens of millions of tests per year, is the TAM worldwide. And as before, you know, the cost of goods is very low compared to what can be charged for it. So it's a very high margin product and a big need. So in all our areas, the margins are very good in the process. But the exact size, the cat market, I guess we'll find out once the product's launched. But I would look at it as a smaller potential market than a dog market, but large nonetheless. with.

All right. Thank you very much, Kevin. I really appreciate you taking my questions today. Thank you. Take care.

And our next question will come from Justin Walsh with Jones Trading.

Hi. Thanks for taking the question. It would be great if you could provide some additional color on the reimbursement approval process relevant to NUCU lung cancer in France.

Any potential risk there and how that process compares to comparable processes in other regions? yes um it is a different process and um there's always risks in reimbursements so uh nothing by any means is a fait accompli until it's done um but the french government have several programs now where they're trying to get encourage more tests to come on the market um and we had our first pre-submission meeting a few weeks ago and we're still very hopeful of getting this first level um approved it's a bit different from the system in the us and there's quite a few you know complications I can probably go through it all offline but several aspects to your question we are very very happy that we're in this process with the French government and they'll allow us to collect a large amount of data once the reimbursements are working in France and start helping people but it is a different system to the US so I can I can go through it's probably take a half an hour to go through it I won't do it on this call but it's a different process but it's something which we're very happy with how it's going as I said we have the pre-submission meeting and we expect to have the first news on that later this year and be helping people in real life in France next year.

Thanks for taking the question. Thank you.

We'll go next to Yi Chen with H.C. Wainwright.

Good morning. This is Katie on for Yi. Thinking about your revenue quarter over quarter, how much of the first half's growth was one-time deferred revenue versus catch-up versus organic growth and ramp. And what do you expect your underlying run rate growth trajectory to be?

Terry, do you want to answer your question? Yeah, thanks, Katie. This is Terry. Yeah, it's a good question. In the quarter, we did have probably a 50-50 split between deferred revenue and an actual product revenue. That deferred revenue is coming from the HESCA agreement. So as we ship tests in the vet space, we recognize a portion of that revenue, and that's over the life of the agreement. So, we'd expect something similar going forward through the balance of the year. So, again, we're not providing guidance on individual lines, but we would expect a similar performance over the balance of the year.

Does that answer your question?

Yes.

Quick follow-up. Should we expect quarterly revenue to be inconsistent, or are we expecting it to smooth out over time? Are there specific catalysts coming up that change stage two?

At this stage, and that's why we're not giving guidance, it is particularly lumpy. We're not expecting it to smooth out any time soon. Part of it is shipping of large orders. Part of it is Discover services, which is dependent on project revenue being recognized. And that's where you saw we had a fairly flat quarter this quarter, partly because of the timing of the project delivery in Discover Services. We do have a good pipeline of large projects, but we are subject to our partners' timelines to a certain extent in terms of how we recognize that. but yeah again we expect to see growth over the full year it's difficult to say one quarter to the next but i'm confident that over the full year we will show growth great thank you i appreciate it and our next question will come from bruce jackson with stonex hi good morning thanks for taking my questions um first um could we get an update on the projects that are ongoing in taiwan

Do you want me to take that, Cam?

Oh, it might have dropped off. I can take that, Bruce. So in terms of Taiwan, I don't know if you recall, but they presented a poster at the NACLC in the US in December and then also again at ELCC this March, and it was around prognostication. And so actually, they've really been focused around this risk stratification for patients ahead of surgery. So they've actually not been, they've not completed the data analysis for the screening section yet of the study because they've been writing up the paper for the prognostication. And this is really helping them. They're looking to introduce it into gene clinical practice now, really looking at the measurement of H3K27 ahead of surgery to help identify those patients that they need to follow up more closely. So that paper should be submitted within the next couple of weeks, and we'll put it up on a preprint service so people can see. But that's why we haven't yet reported the data on the screenings today.

Okay. And then in terms of the feline milestone payment, what's your latest thinking on the timing of receiving that?

Yeah, shall I take that one?

So the paper has been submitted, as you know, and it's still going through the peer review process. We are waiting for reviewers' comments to come back. It is taking a little bit longer than we'd hoped. But, you know, it's just I think it's just a matter of time before that gets published. And then, yeah, then that would complete our obligations in terms of the milestone.

OK, perfect. Thank you very much.

And we'll go next to Stephen Ralston with Zax.

Good morning and good afternoon.

I appreciated the update from the summit program. So, since the fingerprint sample roughly mirrors the accuracy of the Spearman and Pearson correlations, would clinical trials be required to prove the time-to-result benefit? In other words, what will be the regulatory pathway for this?

So, I think the next steps on that program, so as you know, it's a program that's funded by the Balloon Region. And so we're working together with a team there over in Belgium. The next step, because this has definitely been like the technology and the feasibility stage, the next stage is that it will then make the assay into research use-only status, so that it goes through some more quality checks, et cetera. And then it will be tested again in three independent hospitals. for clinical validation. So that will then be the clinical validation stage that we hope to start in early 2027.

And hi, I'm back. Sorry, my phone conked out. And yes, so Stephen, it's one of those things. So when having things correlate very well makes the regulatory process much better for de novo in different countries. And obviously it's much easier if it agrees with what's currently approved in Europe and the process, as you said, with a very strong correlation but that's not to say that there's never going to be any more regulatory work for it but it just makes a lot easier if it agrees with the current tests which are in the lab tests so the gold standard will still be the um currently the remedy machine and we're working on other companies um to to get that done but um at the moment um it's just very it's encouraging from a whole lot of ways it means our platforms are both very stable they're most version the same thing um but as i uh discussed briefly with with uh mike from maxim um it's the numbers are quite you know huge difference when you're talking 37 times uh healthy level in the most extreme cases of of for thrombosis for example um it's both have worked extremely well so the short answer is there will still be regulatory work needed um but we're also looking to use it internationally so um each one of those areas will have slightly different path But in a lot of different ways, having it correlate so well with our current revenue machine, which is the gold standard, helps us tremendously in getting it out there. Does that make sense?

Yes. Yes. Thank you. Looking at it a different way, management has successfully reduced the quarterly operating expenses from over $8 million per quarter back in 2023 to down to $5.2 million in the most recent quarter. And you've relayed some anticipated milestones that could bolster the cash runway in the near term. You've already entered in some agreements that provide upfront cash payments and milestone payments. Have any of the discussions advanced to the level of co-developmental funding?

Yes. So, obviously, we've got to be a little careful because there is a lot of discussions going and they are confidential. I don't want to break any of the agreements we have. But the agreements kind of, and this is probably a good chance just to review where we are with all the different people we're talking to, they kind of come into several categories. There's the autoimmune agreements, which are with QMulti, currently two, we're working on, but two multibillion-dollar companies, Worf and Sysmex. And as you said, they've progressed very well, and they're progressing through the stages of co-development. They're working on their machines, and now we're working through the next phases. We have a deal with Revity, which is obviously their machine and they're co-marketing our CEMR kits to dozens of hospitals in Europe. It's a CEMR kit that they're selling. That's progressing well and we're looking for a bigger agreement with them and that's progressing well. We have an agreement with Hologic to help co-market our new discover. As you probably know, Hologic, they're a very large company as well. um we're in discussion with uh several very large uh diagnostic companies on our new q net uh beyond autoimmune and those other ones which we've already signed and as you can see the data is looking better and better uh with the mayo clinic uh also with um the large french detect step starting collection next month also we're expecting data from a very large study called records as well which was over a thousand also in in France and they're they're progressing but they were waiting for some of this bigger data but that's certainly starting to come through so hopeful of moving them along there's a handful actually more in the cancer space on the capture seek side and those some of the evaluation works already been as well and truly worked through and then there's a range of things were licensing but I will go through that later then also there's all the commercialization which is working on lung prognostic in taiwan in leon and also actually we'll be going through some other stuff which is progressing very well in japan as well um so lots of different areas and they're all at kind of different stages and processes i guess like everyone everyone wants it to go as quick as they possibly can because that's what's going to get at the other side of all the things going on and are actually licensed. But we currently have four agreements signed with multi-billion dollar companies, Wurfen, Sysmex, Revity, and Hologic. And we're working on over a dozen others in those three main areas and governments and large companies. So the secret to unlocking all that is more information on the human cancer side, which we're getting, you know, evaluations as well as for the CaptureSeek, as well as H3K27, all the new QNETs work in trauma and sepsis. And as you heard, we're progressing very well with the Mayo Clinic and the I-10 is now being put in their labs so they can do a lot more work and we're hopeful of them becoming a customer as well. I mean, a customer and a sense of running the test for us as well commercially. So, yeah, it's always – everyone wants to be quicker, of course, including us, but there's been a lot of progress on all those different fronts. Does that help answer your question as much as I can? Yes.

Thank you for the very meaty explanation of your pipeline here in the near future.

Thank you. Excellent. Thank you.

And we'll go next to Ilya Vyubkov with Freedom Capital Markets.

Good afternoon. Thank you for taking the question.

I have just a quick one. Because Discover service revenue was zero in Q2, and you said it was because of project delivery timing, So, I'm just wondering, were these projects expected in Q2 simply pushed into Q3, or has there been any change in the underlying size or conversion rate of Discovery Pipeline?

Tarek, do you want to answer that? Yep. Hi, this is Tarek. It's not that they were necessarily expected in Q2, but as I've said, it is always a challenge to predict when some of these projects will start. I mean, we're dependent on the timelines of our partners when they start clinical trials or other projects so that we can then deliver those and recognize the revenue. that's that uncertainty doesn't change over the next couple of quarters but like I said we do have a pipeline of projects and so it would be expected that some of those will drop but it's very difficult to predict which which ones will start in which quarters that answer the question yeah thank you very much and that concludes our question and answer session I would like to turn the

floor. Back over to Cameron Reynolds for closing comments.

Thank you all for joining us today. And thank you for the analysts for all those great questions. And I hope it's been helpful in outlining where we're going and the progress we're making on all the areas we're doing, and that we're very much focused on getting some of these deals with abreast four multi-billion dollar companies, as we talked about, but we're working on a lot of other and potentially much larger deals. And we hope to update you in short and medium term with how they're all going and some of them being completed so I thank you for your time and take care ladies and gentlemen thank you for your participation this does conclude today's teleconference you may disconnect your lines and have a great day