Spruce Street Capital LP
Filing Date
Global Rank
#2,584
/ 8,232
▲ 1048
Top Industry
Biotechnology
84.7%
3Y Alpha vs SPY
+40.6%
Period ended 2 months ago
Filed May 14, 2026 · 30d
2 quarters · since Dec 2025
Clone Performance
Feb 2026–Jun 2026 · vs SPYHypothetical growth of cloning every reported 13F position and rebalancing on each filing, indexed to the same start.
Cloned portfolio
+19.2%
SPY
+9.1%
Annualised alpha
+40.6%
Max drawdown
−18.8%
Estimate. 13F holdings are quarter-lagged and long-only, so the clone rebalances about 45 days after each period end — when the filing becomes public — and excludes options and short positions. Past performance does not predict future results.
Portfolio Concentration
28 positions · as of Mar 31, 2026 · Δ vs Dec 31, 2025Top Position
10.4%
+0.4 pts
Top 5
42.0%
+0.7 pts
Top 10
65.9%
−2.8 pts
HHI
555
Diversified−28
Portfolio Trend
2 quarters · across all stocks
Sector Breakdown
As of Mar 31, 2026| Sector | % Portfolio | Value |
|---|---|---|
| Healthcare | 98.8% | $412,715,178 |
| Financial Services | 1.2% | $5,080,000 |
Last Quarter's Activity
Export CSVAdded To
Positions the filer increased
12 positions
| Ticker | Company | Δ Shares | Shares | Value | Open |
|---|---|---|---|---|---|
| IPSC | Century Therapeutics, Inc. | +2,637,522 | 4,059,054 | $9,173,462 | |
| RLMD | Relmada Therapeutics, Inc. | +2,175,933 | 6,262,114 | $43,584,313 | |
| ANRO | Alto Neuroscience, Inc. | +1,102,366 | 1,325,210 | $29,790,720 | |
| ALEC | Alector, Inc. | +983,082 | 2,101,068 | $4,517,296 | |
| SVRA | Savara Inc | +972,082 | 3,383,175 | $18,472,135 | |
| LXEO | Lexeo Therapeutics, Inc. | +753,593 | 928,593 | $5,330,123 | |
| ENTA | Enanta Pharmaceuticals Inc | +542,911 | 932,598 | $11,778,712 | |
| KALV | KalVista Pharmaceuticals, Inc. | +509,713 | 897,681 | $18,070,318 | |
| CNTA | Centessa Pharmaceuticals plc | +411,852 | 489,849 | $19,456,802 | |
| LBRX | Lb Pharmaceuticals Inc | +370,566 | 1,376,159 | $33,936,080 | |
| KNSA | Kiniksa Pharmaceuticals International, plc | +326,081 | 761,063 | $36,645,183 | |
| DNTH | Dianthus Therapeutics, Inc. /DE/ | +75,837 | 373,274 | $31,325,154 | |
| No positions match the current search. | |||||
New Positions
Positions the filer opened this quarter
7 positions
| Ticker | Company | Shares | Value | Open |
|---|---|---|---|---|
| ALKS | Alkermes plc. | 317,992 | $11,244,197 | |
| CATX | Perspective Therapeutics, Inc. | 2,627,107 | $10,955,036 | |
| ALMS | Alumis Inc. | 392,574 | $8,648,405 | |
| MAZE | Maze Therapeutics, Inc. | 200,000 | $5,970,000 | |
| ANTX | AN2 Therapeutics, Inc. | 1,661,073 | $5,680,869 | |
| HLXC | Helix Acquisition Corp. III | 500,000 | $5,080,000 | |
| CRVS | Corvus Pharmaceuticals, Inc. | 231,585 | $3,388,088 | |
| No positions match the current search. | ||||
Sold Out
Positions the filer fully exited
5 positions
28 positions ·
$417,795,178 total
· as of Mar 31, 2026
| Ticker | Company | Type | Shares | Value (USD) | % of Portfolio | History |
|---|---|---|---|---|---|---|
| RLMD |
Relmada Therapeutics, Inc.
Healthcare
|
Reduced | 6,262,114 | $43,584,313 | 10.43% | |
| KNSA |
Kiniksa Pharmaceuticals International, plc
Healthcare
|
Added | 761,063 | $36,645,183 | 8.77% | |
| LBRX |
Lb Pharmaceuticals Inc
Healthcare
|
Added | 1,376,159 | $33,936,080 | 8.12% | |
| DNTH |
Dianthus Therapeutics, Inc. /DE/
Healthcare
|
Added | 373,274 | $31,325,154 | 7.50% | |
| ANRO |
Alto Neuroscience, Inc.
Healthcare
|
Added | 1,325,210 | $29,790,720 | 7.13% | |
| RLAY |
Relay Therapeutics, Inc.
Healthcare
|
Held | 2,984,125 | $29,692,043 | 7.11% | |
| CNTA |
Centessa Pharmaceuticals plc
Healthcare
|
Added | 489,849 | $19,456,802 | 4.66% | |
| SVRA |
Savara Inc
Healthcare
|
Added | 3,383,175 | $18,472,135 | 4.42% | |
| KALV |
KalVista Pharmaceuticals, Inc.
Healthcare
|
Added | 897,681 | $18,070,318 | 4.33% | |
| PCVX |
Vaxcyte, Inc.
Healthcare
|
Reduced | 245,709 | $14,278,149 | 3.42% | |
| ELVN |
Enliven Therapeutics, Inc.
Healthcare
|
Reduced | 329,006 | $12,897,035 | 3.09% | |
| SRZN |
Surrozen, Inc./DE
Healthcare
|
Held | 432,040 | $12,585,325 | 3.01% | |
| ENTA |
Enanta Pharmaceuticals Inc
Healthcare
|
Added | 932,598 | $11,778,712 | 2.82% | |
| ALKS |
Alkermes plc.
Healthcare
|
NEW | 317,992 | $11,244,197 | 2.69% | |
| CATX |
Perspective Therapeutics, Inc.
Healthcare
|
NEW | 2,627,107 | $10,955,036 | 2.62% | |
| NERV |
Minerva Neurosciences, Inc.
Healthcare
|
Held | 1,655,500 | $9,974,387 | 2.39% | |
| IPSC |
Century Therapeutics, Inc.
Healthcare
|
Added | 4,059,054 | $9,173,462 | 2.20% | |
| ALMS |
Alumis Inc.
Healthcare
|
NEW | 392,574 | $8,648,405 | 2.07% | |
| SABS |
SAB Biotherapeutics, Inc.
Healthcare
|
Held | 2,198,502 | $8,420,262 | 2.02% | |
| ERAS |
Erasca, Inc.
Healthcare
|
Reduced | 422,543 | $6,836,745 | 1.64% | |
| IKT |
Inhibikase Therapeutics, Inc.
Healthcare
|
Held | 3,581,603 | $6,017,093 | 1.44% | |
| MAZE |
Maze Therapeutics, Inc.
Healthcare
|
NEW | 200,000 | $5,970,000 | 1.43% | |
| ANTX |
AN2 Therapeutics, Inc.
Healthcare
|
NEW | 1,661,073 | $5,680,869 | 1.36% | |
| LXEO |
Lexeo Therapeutics, Inc.
Healthcare
|
Added | 928,593 | $5,330,123 | 1.28% | |
| HLXC |
Helix Acquisition Corp. III
Financial Services
|
NEW | 500,000 | $5,080,000 | 1.22% | |
| ALEC |
Alector, Inc.
Healthcare
|
Added | 2,101,068 | $4,517,296 | 1.08% | |
| LONA |
LeonaBio, Inc.
Healthcare
|
Held | 393,701 | $4,047,246 | 0.97% | |
| CRVS |
Corvus Pharmaceuticals, Inc.
Healthcare
|
NEW | 231,585 | $3,388,088 | 0.81% |