Welcome to Amarin Corporation's Conference Call to discuss its Fourth Quarter and Full Year 2024 Business Update and Financial Results. I would like to turn the conference call over to Mark Marmur, Vice President, Corporate Communications and Investor Relations at Amarin.

Good morning, everyone, and thank you for joining us. Turning to Slide 2 and our forward-looking statements. Please be aware that this conference call will contain forward-looking statements that are intended to be covered under the Safe Harbor provided under Federal Securities Law. We may not achieve our goals, carry out our plans or intentions, or meet the expectations disclosed in our forward-looking statements. Actual results or events could differ materially, so you should not place undue reliance on these statements. We assume no obligation to update these statements as circumstances change. Our forward-looking statements do not reflect the potential impact of significant transactions we may enter into such as mergers, acquisitions, dispositions, joint ventures, or any material agreements that we may enter into amend or terminate. For additional information concerning the risk factors that could cause actual results to differ materially, please see the Risk Factors section of our annual report on Form 10-K for the year ended December 31, 2024, which has been filed with the SEC and is available through the Investor Relations section of our website at www.amarincorp.com. We encourage everyone to read these documents. An archive of this call will be posted on Amarin's website in the Investor Relations section. Turning to Slide 3 and today's agenda. Aaron Berg, Amarin's President and Chief Executive Officer will provide an update on the state of the Amarin business. Pete Fishman, Amarin's Chief Financial Officer will review our fourth quarter financial results. And Steve Ketchum, Amarin's Executive Vice President, President of R&D and Chief Scientific Officer will provide an update on recent and upcoming VASCEPA/VAZKEPA research. And at the end of the presentation, Aaron Berg will provide closing remarks followed by a question-and-answer session. I will now turn the call over to Aaron Berg, President and Chief Executive Officer of Amarin. Aaron?

Thank you, Mark. Good morning, everyone, and thank you for joining us here today. Let me begin my comments by focusing on our progress and the opportunity ahead to realize the value of VASCEPA globally, as well as the ADS ratio change referenced in the press releases this morning, a strategic action we've taken to address a key issue for the company. Since taking on the role of CEO in the middle of last year, I spent a significant part of that time working with our leadership team and in coordination with the board of directors to identify and take advantage of opportunities to rapidly accelerate momentum, strengthen the foundation for long-term growth, and drive greater value now and for the future. We've made progress in this effort and the opportunity that we have ahead with VASCEPA is built on a strong foundation. We have a strong financial foundation, with 2024 revenues of over $200 million and a cash position of almost $300 million and no debt. This financial position helps solidify a long runway for Amarin. The science of VASCEPA, which is underpinned by the REDUCE-IT study and more than 500 additional publications, advances understanding of the icosapent ethyl clinical benefits and mechanisms of action and its complementary position to impact the cardiovascular risk burden and unmet need around the world. This extensive science has helped drive regulatory progress globally. To date, we've secured approvals in 49 markets where we're in the early stages of obtaining pricing and reimbursement agreements, commercial launches, or still progressing through the regulatory approval processes, all of which set the stage for future growth. Increasingly, we've expanded access to commercial penetration with the product launched in more than 20 markets globally, either directly or through our nine partnerships in place currently. There are also 16 additional countries in various stages of progress toward commercialization. The significant revenue generation led by continued capture of efficient brand new revenue in the US, followed by growth in Europe and the rest of the world markets positions the VASCEPA franchise to deliver on its tremendous opportunity globally. We know we have much more work to do to capitalize on this opportunity, but overall, taking into consideration the considerable untapped potential of the franchise, our continued progress in its global expansion, and the financial foundation and long cash runway we have in place, we believe there is a disconnect between the value potential and our current company valuation. Regarding the ADS ratio change, as a publicly traded company, we see considerable value in maintaining our NASDAQ listing. To that end, today we announced our intent to initiate a ratio change to our ADS program in order to preserve our NASDAQ listing. This step is an expression of our determination and commitment to realizing the full value potential of Amarin. Pete will cover this in greater detail later in the presentation, and I encourage everyone to review today's press release on this matter for additional information. Turning to Slide 6, let me now briefly walk you through the past 12 months plus and provide details on our progress and key accomplishments, including the strategic decisions and steps we've taken that have helped us drive value. From a strategic standpoint, we successfully extended our intellectual property position in Europe, widening our IP horizon for VASCEPA through 2039. This is important as it extends the runway for exclusivity and the opportunity for this brand in Europe. We've continued to execute our new commercial and pricing and reimbursement strategy in Europe, tailored to each country and focused on very high-risk patients. These are patients with established cardiovascular disease and there are currently over 5 million such patients in Europe, a significant opportunity to impact a large patient population. This strategy has accelerated our progress in the region. We've secured pricing and reimbursement in 10 markets since adopting this new strategy, and in-market demand grew in every launch market in Q4 versus Q3. We've also continued to focus our financial strategy on efficient cash management and operating expense deployment focused only on the most value-driving efforts. This has helped us extend our cash runway. Finally, as I mentioned, we announced earlier this morning that we're taking steps to maintain one of our critical corporate assets, our NASDAQ listing. Operationally, we've made continued progress across the business. In Europe, on the commercialization front, VASCEPA revenues continue to gradually increase throughout 2024, driven by growth in Spain, the UK, and central Eastern Europe markets. While we've seen early demand in a number of these markets, we must find ways to accelerate growth where VASCEPA has been launched. Pricing and reimbursement efforts have also advanced, with pricing and reimbursement secured in Italy, Portugal, Greece, and most recently last month in Austria. Importantly, in Italy, we've already secured access in nine regions, which represent more than 50% of the total eligible market in that country, reflecting strong interest in gaining access to the product in the market. In the US throughout 2024, we've continued to efficiently generate cash with VASCEPA more than four years after the introduction of generic products. Exclusives, which now represent 74% of the total VASCEPA branded business, cover approximately 43 million total lives, which represents approximately 40% of the total commercial and Medicare Part D IPE volume. Additionally, as we previously stated, we have a plan of action and are prepared to launch an authorized generic when the time is optimal. Across various regions of the rest of the world, 2024 saw continued progress in regulatory efforts, expanding access and generating demand for VASCEPA through existing partnerships. While early in the launch phase for a number of these markets, all partners saw growth in market demand for the product in Q4 and continued to work to expand access and further accelerate growth. Two of our partners launched in cardiovascular risk reduction, EddingPharm in China and CSL Seqirus in Australia. EddingPharm received regulatory approval in China mid-year for cardiovascular risk reduction and are now focused on promoting for at-risk patients with access to private hospitals and high-risk patients in public hospitals with inpatient acute coronary syndrome patients as the priority in this initial stage of the commercial cardiovascular risk reduction launch. Their effort is currently focused on the self-pay market in China as they continue advancing efforts to support the inclusion on the National Retail Drug Listing or NRDL. In Australia, our partner CSL Seqirus secured Australia's Pharmaceutical Benefit Scheme or PBS price listing for VASCEPA, unlocking public access to the product for patients with ASCVD and elevated triglycerides in that market. CSL officially launched at the annual scientific meeting of the Cardiac Society of Australia and New Zealand in August 2024, the largest cardiology meeting in Australia and New Zealand, with more than 400 delegates attending. While very early, they're seeing strong in-market demand in Australia. HLS received reimbursement in Alberta to round out their full public access across the country, adding opportunity for growth beyond their significant private insurance coverage for Canada. Biologics in the MENA region progressed their commercial efforts and saw increased sales in the region. They worked to continue their growth in Saudi Arabia specifically as they worked with the health authorities to further expand access to the patients with public reimbursement there. We continue to progress our regulatory efforts in Southeast Asia, where our partner is Lotus and expect first approvals to be sometime in 2026. Amarin continues to support our partners with our medical team to attend international scientific leader involvement at multiple medical conferences, specific scientific leader programs, launch efforts, as well as working to secure publications locally for the commercialized regions. Supporting our efforts to generate worldwide growth are our medical affairs, R&D, and regulatory teams who continue to expertly and tirelessly advocate for and advance the science behind VASCEPA. More than five years from the approval of VASCEPA in the US for cardiovascular risk reduction, we and others are continuing to generate meaningful data that helps the clinical community further understand the underlying science and the potential added benefit of VASCEPA to further reduce the risk of cardiovascular events in patients on standard of care therapy with well-controlled LDL levels. This significant and continuously expanding body of evidence helps propel our commercial, medical advocacy, and regulatory progress, which Steve will review in greater detail later. And finally, from a financial perspective, we continue to make smart decisions to balance operating expenses and cash preservation with the urgent need to accelerate global revenue growth. Specifically, we closed out 2024 having generated $228.6 million in total revenue and a stable capital structure. For the year, we reduced our year-over-year operating expenses by 26%, including the $50 million annual operating expense reduction we committed to in 2023. We ended the year with a strong cash position of $294 million, underscoring our prudent cash management and continued focus on strengthening our financial foundation. These financial accomplishments were accompanied by our successful efforts to renegotiate product supply agreements. These successful negotiations allow us to align our short-term supply commitments based on current demand in order to conserve important capital while ensuring we can supply the brand across markets as we build momentum with a growing global customer base. In summary, 2024 was a year of continued progress in numerous aspects of our business driven by the execution of the entire Amarin organization. We take very seriously our obligation to drive shareholder value, and while we've made progress, we have much more work to do to drive shareholder value, primarily by urgently getting VASCEPA into the hands of as many at-risk patients around the world as possible. We know the unmet need is there, and while the last several years have been challenging, we've remained steadfast in our efforts to drive continued positive progress in realizing this product's global potential. We remain confident we will generate further momentum in 2025, building off 2024. With that, let me turn the call over to Pete Fishman, who will take us through the financial results, as well as the specifics regarding the ADS ratio change announced earlier this morning. Pete?

Thank you, Aaron. Good morning, everyone. Turning to Slide 8. In the fourth quarter of 2024, Amarin reported total net revenue of $62.3 million, including net product revenue of $60.1 million and $2.2 million of licensing and royalty revenue, compared to total net revenue of $74.7 million in the fourth quarter of 2023. U.S. Product revenue was $44.2 million compared to $64.9 million in the fourth quarter of 2023. This decline was driven by lower net selling price due to generic competition and a decrease in volume in the second half of the year stemming from CVS commercial moving from exclusive to not covered. Looking ahead, we anticipate continuing to see the impact of this on our year-over-year comparisons through the first two quarters of 2025. Despite the revenue decline, the U.S. business continues to deliver significant cash, and as Aaron said earlier, to exhibit resilience with a remarkable track record for a branded product this far out from the introduction of generics. European product revenue was $4 million, a $2.5 million increase over the prior year period and driven primarily by growing contributions from Spain and the UK. Fourth quarter 2024 product revenue was consistent with the prior quarter, which included supply shipments to our partner in Greece. Spain and the UK continue to be the current drivers of revenue growth for this important and evolving region. Product revenue also reflects revenue from our partnerships throughout the rest of the world of $11.9 million, a $7.7 million increase over the prior year period. These partnerships continue to generate meaningful cash contributions with no direct cost incurred by the company. It is important to note that in the current year, product revenue with our partners includes supply shipments in preparation for market launches. Our partnership revenue can be variable quarter-to-quarter and year-to-year based on restocking timing relative to in-market demand. Cost of goods sold excluding non-cash inventory restructuring of $36.5 million was $35.4 million in the fourth quarter compared to $29.6 million in the prior year period. Gross margin excluding non-cash inventory restructuring was 41% compared to 58% in the prior year period as a result of a decline in net selling price in the US. Total operating expenses were $43 million, including $37 million in SG&A and $6 million in R&D, which is a reduction of approximately $7 million compared to the prior year period and reflects the impact of ongoing cost optimization initiatives. We will continue to focus on deploying our capital on value-driven efforts. Turning to the bottom line, fourth quarter 2024 GAAP net loss was $48.6 million compared to a GAAP net loss of $5.8 million in the prior year period, primarily reflecting the impact of the U.S. generic market and the sizeable effect on cost of goods sold as a result of non-cash inventory restructuring charges. Turning to Slide 9 and our efforts and results in controlling costs and effectively managing our cash. As of December 31, 2024, we reported aggregate cash and investments of $294 million. In addition, and equally as important, we ended the year with no debt. Over the last two years, we have made significant progress in right-sizing our operations while improving our strategic focus and navigating the ongoing challenges to our U.S. product revenue. While doing this, we have also made investments to further expand the reach of VASCEPA globally. As a result of these efforts, we have successfully maintained a stable cash position over the last nine quarters. To quantify that, our cash has only declined approximately 5%, or less than $20 million since year-end 2022. Fundamental to that track record of prudence and success has been and will continue to be commitment to balancing a combination of managing costs and pursuing strategic decisions and channels to urgently expand product revenue. Now let me pivot to this morning's announcement. As referenced by Aaron earlier in the call, we continue to believe that our stock is undervalued given the progress we've made and the global opportunity for VASCEPA. Amarin's NASDAQ listing is important both for investors and for the company. For shareholders, a listing allows individuals and investment entities to participate in the growth of VASCEPA through the public equity capital markets. With this in mind and with our commitment to remain listed on the NASDAQ, this morning we announced our intent to effect a ratio change on our ADSs from 1 ADS representing 1 ordinary share to the new ratio of 1 ADS representing 20 ordinary shares. The objective of the ratio change is intended to increase the per share market price of the company's ADSs to comply with NASDAQ's $1 minimum bid price per share requirement and maintain the company's listing on the NASDAQ capital market. As a result of the ratio change, each Amarin ADS holder will see the number of ADSs they hold divided by 20. For example, if an Amarin ADS holder holds 100 ADSs on the effective date, the holder will hold five ADSs following the ADS ratio change. This ratio change also has the same effect on the company's total outstanding shares. Importantly, the overall value of holders' ADSs does not change as a direct result of the ADS ratio change. The effective date of the ratio change is expected to be on or about April 11th, 2025. For the benefit of shareholders, we have posted to the investor relations section of the company's website a Q&A addressing key questions investors may have about the ratio change.

Thank you, Pete. Good morning, everyone. Before I discuss recent and upcoming research, I wanted to take a few moments to speak to critical foundational elements for VASCEPA and its therapeutic value for patients around the world. Namely, maintaining focused investment in research enables us to shed further light on the science behind our product and publishing the results of such research helps to drive medical advocacy for our product. As Aaron mentioned, the molecule icosapent ethyl, the active ingredient in VASCEPA, is built on tremendous science. Since 2011, both Amarin and its partner investigators have supported more than 500 publications to advance our understanding around the science of icosapent ethyl or IPE and to further elucidate the potential mechanisms of action for the Omega-3 eicosapentaenoic acid or EPA component of this ethyl ester molecule. Research insights into both IPE and EPA are fundamental to furthering our primary goal of maximizing the value and impact potential of our product globally. Looking at 2024 specifically, we supported and delivered significant additional scientific research on IPE and EPA. Amarin and global medical and scientific collaborators supported 45 publications inclusive of accepted abstracts, posters, presentations, manuscripts, review articles, and book chapters across the past year. The breadth and depth of our ongoing scientific efforts have fueled significant global medical advocacy for IPE. In total, we have secured more than 50 clinical guidelines, consensus, or scientific statements on the therapeutic value of VASCEPA/VAZKEPA from global medical societies. Strong data from our REDUCE-IT cardiovascular outcomes study and from our Supportive Development Program have directly driven our regulatory progress. Over the last three years, we have filed for regulatory review in 22 countries and regions and have received approval for the REDUCE-IT clinical indication in 15 countries and regions outside of the United States, including in mainland China, Switzerland, Australia, New Zealand, and Israel. We and our partners are advancing regulatory processes in seven additional rest of world markets. Turning to Slide 12 in support of clinical data, a post hoc analysis of REDUCE-IT was recently published in the Journal of the American Heart Association, evaluating the impact of icosapent ethyl on patients with various LDL-C levels at baseline. This analysis showed consistent cardiovascular risk reduction benefit irrespective of baseline LDL-C level. Even when a patient had a very low baseline LDL-C level less than 55 milligrams per deciliter or down to 40 milligrams per deciliter, patients were still at risk and derived cardiovascular benefit taking VASCEPA. This data reinforces that VASCEPA is a complementary therapy to current LDL-C lowering therapies. In other words, one of the primary advantages of VASCEPA is that it can be added to standard of care or SOC LDL-C lowering therapies and still further reduce the residual cardiovascular risk of a major cardiovascular event. By VASCEPA being complementary, there is no need to displace LDL-C lowering drugs. This is a commercial advantage for our product as it can be a significant challenge for companies with branded LDL-C lowering drugs to compete head-to-head with other LDL-C products. We firmly believe that the value of VASCEPA as a complement to lipid lowering therapy should be more strongly considered by clinicians globally to help address and reduce residual cardiovascular risk. It should be noted that we are focusing on secondary prevention patients, as many patients with well-controlled LDL-C still have major cardiovascular events, including heart attacks and strokes. The groundbreaking results from the REDUCE-IT outcomes trial proved that VASCEPA lowered the chance of patients experiencing a life-threatening cardiovascular event, such as a heart attack or stroke, by 25% when added to a statin. This is why medical providers should be aware of the REDUCE-IT outcomes data and should add VASCEPA on top of LDL-C lowering statin therapy for their at-risk patients rather than adding another LDL-C lowering drug. Turning to Slide 13, our team will be supporting two abstracts at the upcoming American College of Cardiology meeting in Chicago later this month. The data being presented by investigators at ACC.25 will further enhance the medical community's understanding regarding the potential mechanistic activities of EPA administered clinically in the form of VASCEPA icosapent ethyl in reducing cardiovascular events in at-risk patients. Specifically, the data will focus on the antioxidant effects of EPA on lipoprotein(a) Lp(a) in rich plasma and the effects of a GLP-1 receptor agonist in combination with EPA on the expression of antioxidant proteins in endothelial cells in vitro. High Lp(a) concentrations are associated with increased cardiovascular event risk and people with high levels face a 2 to 4 times greater risk of having an early event. With about 20% of the global population affected, research is crucial for understanding and addressing elevated Lp(a), and the medical community has increased its focus on Lp(a) as a key cardiovascular risk factor. We see potential value and opportunity for VASCEPA and its potential impact to help address key areas driving residual cardiovascular event risk. Multiple new therapies are in development to treat cardiovascular risk beyond LDL-C lowering. However, it is our view that clinicians should not wait for new agents when a product like VASCEPA is already available for at-risk patients. With the advancement of therapeutic approaches that address other domains of residual cardiovascular risk, our ongoing research becomes more important because there could be additional therapeutic benefits, whether overlapping protective mechanisms or additive mechanisms in combining EPA with emerging therapies like GLP-1 receptor agonists that have been clearly shown to reduce cardiovascular risk on top of statin therapy. With widespread GLP-1 use, there are likely an increasing number of patients with lipid abnormalities requiring statin therapy and with other comorbidities and risk factors that are in need of a complementary therapy like VASCEPA to further reduce cardiovascular events. At Amarin, it is important for us to continue exploring the science behind IPE and the potential mechanisms by which EPA contributes to reducing cardiovascular risk. We intend to further advance this evidence base supporting the utility and value of VASCEPA.

Thanks, Steve. Turning to Slide 15, as you've heard today, we've made operational progress while also maintaining a solid financial foundation with a long cash runway and no debt. We have much more to do to capitalize on the untapped global potential for VASCEPA. This is what drives our priorities and informs the steps we continue to take to maximize shareholder value. Let me reaffirm our priorities for 2025. First, we're focused on maintaining the critical NASDAQ listing by completing the ADR ratio change. Our public listing is important to us as a public company and to our shareholders. Second, we'll continue to focus on driving momentum in Europe where we have patent protection out to 2039 and the rest of the world through our partnerships. We remain early in the commercialization stages in these regions outside the U.S., and these are the regions that provide the greatest opportunity for long-term revenue growth and overall value for shareholders. Third, we'll continue to drive efficient revenue while taking steps to maximize profitability in the U.S. Fourth, as Steve mentioned, there continues to be much more to learn about this unique molecule, icosapent ethyl, and we will continue to support research that drives greater understanding and awareness of the therapeutic value and impact of VASCEPA for patients and payers. This is critically important as this product has proven to be tremendously valuable as a complementary cost-effective therapy to widely used lipid-lowering drugs in reducing cardiovascular risk. Finally, we'll continue to exhibit financial and operational discipline. While we focus on these critical strategic operational financial priorities in 2025, I want to end on a key point that brings us all back to the single biggest and most impactful opportunity before us, addressing the number one killer globally, cardiovascular disease. As we sit here today, right now we have a product available to clinicians that has been proven to be a valuable tool to address this global challenge. In conjunction with widely used lipid lowering agents focused on LDL lowering, VASCEPA can directly address cardiovascular risk and potentially change the curve of incidence of cardiovascular events worldwide. LDL lowering alone is not enough. Approximately 30% of patients that have experienced a myocardial infarction have well-controlled LDL-C at less than 55 milligrams per deciliter. And about 15% to 20% of those patients will experience another event in one to three years. Providers can and need to do more for patients now to reduce cardiovascular events by addressing this risk head-on. Today, millions of providers globally have the power and access to a proven therapy of VASCEPA. We remain committed to accelerating the pace that they have access to and use our product in the name of helping patients from the world's leading cause of death, an essential priority for us here at Amarin. Before we turn to Q&A, I'd like to take a final moment to thank our Amarin colleagues and partners around the world for their continued commitment and dedication. Your efforts are deeply appreciated, and know that you're impacting the lives of at-risk patients around the world. So thank you. With that, operator, let's begin the Q&A portion of the call.

Certainly. At this time, we will be conducting a question-and-answer session. Your first question for today is from Jessica Fye with JP Morgan.

Great. Good morning, guys. Thanks for taking my question. Can you talk about the factors influencing U.S. net price in the fourth quarter? It came in a little bit higher than our estimate, looks like higher than net price over the past couple of quarters. So curious kind of what the drivers were there and just how to think about U.S. net price in the coming quarters. Thank you.

Hi Jess. First of all, as you know, it's an increasingly competitive market and the majority of our business is in exclusives and branded products. However, the mix of our business can change over time and may vary from quarter to quarter, which can lead to some fluctuations. I have Pete here with me who can provide more details on what occurred in Q4.

Sure. Hi, Jess. Thanks for the question. As Aaron mentioned, there is some variability in the business mix, which has driven our revenue increase in Q4 compared to previous quarters. As you know, in Q3, we transitioned CVS commercial from exclusive to not covered, and this trend continued into Q4 2024, impacting volume. This shift in business mix has led to a transition from higher rebates to lower rebates this year. Looking into 2025, you can expect to see the effects of this volume change in the first two quarters due to the CVS exclusive to not covered transition, along with ongoing pricing pressure from exclusive contracts.

Thank you.

Thank you.

Your next question is from Roanna Ruiz with Leerink.

Hi, this is Maisie on for Roanna. Just one from us actually. So as you mentioned, you ended the year with $300 million in cash. So curious what your outlook is on building the pipeline, either internally or externally, through BD, and what therapeutic areas are you most excited about?

Thank you for the questions. From a business development perspective, we will always remain opportunistic. Our primary focus is on executing with VASCEPA and VAZKEPA in Europe. We intend to invest our available cash wisely to generate returns. We have a solid foundation and it's advantageous to have a second product as a potential opportunity. While our primary focus is cardiovascular, there are many exciting developments in cardiometabolics at various stages. Right now, our attention is on leveraging our strengths, especially the significant untapped potential of VASCEPA globally. We are just beginning this journey. The situation in the US is well-known to you, but in other regions, we are just starting, with ample opportunity and a long runway until 2039 in Europe. There is a lot of work ahead, but the possibilities are promising.

Got it. Thank you so much.

Your next question for today is from Paul Choi with Goldman Sachs.

Hi, good morning. This is Daniel on for Paul. We were wondering if you could provide more colors on what is driving the rest of the world revenue growth and if there is like better geographical breakdown of the contributions? Thank you very much.

So I didn't catch the last part of that on the contributions. Sorry about that.

Yes. Could you provide more colors on the actual geographical breakdown of the rest of the world contributions?

Overall, we are still in the early stages in most regions, similar to Europe. There is significant work ahead to establish medical advocacy and secure access, both in private and public sectors. Each country and region presents unique challenges, but we are fortunate to have strong partners who are knowledgeable and passionate about the drug and recognize the potential in their areas. However, gaining access takes time. For instance, we discussed China, and now with the recent inclusion of Australia, we see substantial opportunities in these sizable markets, especially given China's potential. In Asia, we have collaborations with Lotus, and we are making progress through regulatory processes, looking forward to launches in several countries. Additionally, HLS in Canada has expanded to Alberta, and we hope they can achieve growth in the public sector as it develops. Overall, we are witnessing the essential elements of a drug launch. This drug performs well once people are educated about it. As Steve highlighted, we have ample scientific support to promote it. There is clearly a distinctive role for this drug, and while it takes time to educate providers and payers, we anticipate strong adoption once that education is complete.

Yes, they're very helpful. Thank you.

So that's the end of the questions that we have. So, first I just want to say thank you very much for your continued commitment and interest in Amarin and thanks for taking the time today. We appreciate it. Have a good day.

This concludes today's conference, and you may disconnect your lines at this time. Thank you for your participation.