GH · Guardant Health, Inc. · Insider Trading

The restricted stock unit award granted on November 8, 2024 vests over a four-year period. 25% of the shares subject to such award vested on October 21, 2025 and the remaining 75% vests monthly for the three-year period thereafter.

Not applicable for Restricted Stock Units.

The restricted stock unit award granted on July 17, 2024 vests over a four-year period. 25% of the shares subject to such award vested on July 17, 2025 and the remaining 75% vests monthly for the three-year period thereafter.

Not applicable for Restricted Stock Units.

Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $177.08 to $177.945. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.

Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $176.055 to $176.88. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.

Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $175.02 to $176.01. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.

Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $173.98 to $174.975. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.

The restricted stock unit award granted on March 6, 2023 vests over a four-year period. 25% of the shares subject to such award vested on March 15, 2024 and the remaining 75% vests monthly for the three-year period thereafter.

Not applicable for Restricted Stock Units.

The restricted stock unit award was granted on September 12, 2025 and vests over a four-year period. 25% of the shares subject to such award vested on September 12, 2026 and the remaining 75% vests monthly for the three-year period thereafter.

Not applicable for Restricted Stock Units.

Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $157.99 to $158.215. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.

Reflects changes in form of ownership from Helmy A. Eltoukhy Revocable Trust to The Eltoukhy Foundation.

Reflects a gift of shares to a Donor Advisory Fund at Vanguard.

Reflects changes in form of ownership from Helmy A. Eltoukhy Revocable Trust to The Eltoukhy Foundation.

Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $168.87 to $169.73. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.

Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $169.88 to $170.50. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.

The restricted stock unit award granted on November 8, 2024 vests over a four-year period. 25% of the shares subject to such award vested on October 21, 2025 and the remaining 75% vests monthly for the three-year period thereafter.

Not applicable for Restricted Stock Units.

Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $167.81 to $168.60. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.

The restricted stock unit award granted on July 17, 2024 vests over a four-year period. 25% of the shares subject to such award vested on July 17, 2025 and the remaining 75% vests monthly for the three-year period thereafter.

Not applicable for Restricted Stock Units.

The restricted stock unit award granted on March 6, 2023 vests over a four-year period. 25% of the shares subject to such award vested on March 15, 2024 and the remaining 75% vests monthly for the three-year period thereafter.

Not applicable for Restricted Stock Units.

Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $162.80 to $163.78. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.

Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $165.85 to $166.825. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.

Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $164.825 to $165.82. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.

Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $163.81 to $164.805. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.

This represents a stock option award granted on November 8, 2024 that vests over a three-year period. 33% of the shares subject to such award vested on October 1, 2025 and the remaining 67% of the shares vests in equal monthly installments over the remaining two-year period thereafter.

Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $167.695 to $168.02. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.

This represents a stock option award granted on February 26, 2024 that vests over a three-year period. 33% of the shares subject to such award vested on January 2, 2025 and the remaining 67% of the shares vests in equal monthly installments over the remaining two-year period thereafter.

Reflects changes in form of ownership from Helmy A. Eltoukhy Revocable Trust to The Eltoukhy Foundation.

Reflects changes in form of ownership from Helmy A. Eltoukhy Revocable Trust to The Eltoukhy Foundation.

Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $170.20 to $170.67. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.

Reflects changes in form of ownership from Talasaz and Eskandari 2017 Family Trust due to the gift of shares to The Talasaz Family Foundation.

Reflects changes in form of ownership due to gift of shares to a DAF in the Saia Family Foundation.

This represents a stock option award granted on August 3, 2021 that vested over a four-year period and is now 100% vested.

Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $169.195 to $170.19. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.

This represents a stock option award granted on December 13, 2023 that vests over a three-year period. 33% of the shares subject to such award vested on October 1, 2024 and the remaining 67% of the shares vests in equal monthly installments over the remaining two-year period thereafter.

Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $167.12 to $167.8325. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.

Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $168.185 to $169.175. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.