PGEN · Precigen, Inc.

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $7.38 to $7.59, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (1) to this Form 4.

The stock options vested 25% on July 22, 2025 and in equal monthly installments for three years thereafter.

Represents shares sold pursuant to the terms of a 10b5-1 plan adopted by the reporting person.

Represents shares sold pursuant to the terms of a 10b5-1 plan adopted by the reporting person.

The stock options are fully vested.

Represents the number of shares of Precigen common stock withheld by the Issuer to satisfy income tax withholding obligations in connection with the settlement of the RSUs.

Each restricted stock unit ("RSU") represents a contingent right to receive one share of Precigen common stock.

Each restricted stock unit ("RSU") represents a contingent right to receive one share of Precigen common stock.

Represents the number of shares of Precigen common stock withheld by the Issuer to satisfy income tax withholding obligations in connection with the settlement of the RSUs.

Each restricted stock unit ("RSU") represents a contingent right to receive one share of Precigen common stock.

Represents 1/24 of the RSUs granted on June 26, 2025 that vested on August 23, 2026.

Each restricted stock unit ("RSU") represents a contingent right to receive one share of Precigen common stock.

Represents 1/24 of the RSUs granted on June 26, 2025 that vested on August 23, 2026.

Each restricted stock unit ("RSU") represents a contingent right to receive one share of Precigen common stock.

Each restricted stock unit ("RSU") represents a contingent right to receive one share of Precigen common stock.

Represents 1/24 of the RSUs granted on June 26, 2025 that vested on August 23, 2026.

Each restricted stock unit ("RSU") represents a contingent right to receive one share of Precigen common stock.

Represents 1/24 of the RSUs granted on June 26, 2025 that vested on August 23, 2026.

Each restricted stock unit ("RSU") represents a contingent right to receive one share of Precigen common stock.

Represents the number of shares of Precigen common stock withheld by the Issuer to satisfy income tax withholding obligations in connection with the settlement of the RSUs.

Each restricted stock unit ("RSU") represents a contingent right to receive one share of Precigen common stock.

Represents 1/24 of the RSUs granted on June 26, 2025 that vested on August 23, 2026.

Each restricted stock unit ("RSU") represents a contingent right to receive one share of Precigen common stock.

Represents the number of shares of Precigen common stock withheld by the Issuer to satisfy income tax withholding obligations in connection with the settlement of the RSUs.

Represents the number of shares of Precigen common stock withheld by the Issuer to satisfy income tax withholding obligations in connection with the settlement of the RSUs.

The stock options are fully vested.

Represents shares sold pursuant to the terms of a 10b5-1 plan adopted by the reporting person.

Represents shares sold pursuant to the terms of a 10b5-1 plan adopted by the reporting person

Represents shares sold pursuant to the terms of a 10b5-1 plan adopted by the reporting person.

The stock options are fully vested.

Represents shares sold pursuant to the terms of a 10b5-1 plan adopted by the reporting person.

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $6.00 to $6.15, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) to this Form 4.

Represents shares sold pursuant to the terms of a 10b5-1 plan adopted by the reporting person.

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $5.39 to $5.67, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) to this Form 4.

The stock options are fully vested.

Represents shares sold pursuant to the terms of a 10b5-1 plan adopted by the reporting person.

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $5.75 to $6.04, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) to this Form 4.

Represents shares sold pursuant to the terms of a 10b5-1 plan adopted by the reporting person.

The stock options are fully vested.

Represents shares sold pursuant to the terms of a 10b5-1 plan adopted by the reporting person.

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $5.74 to $5.86, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) to this Form 4.

Represents the number of shares of Precigen common stock sold pursuant to a sell-to-cover transaction to satisfy tax withholding obligations upon the vesting of restricted stock units on May 23, 2026.

Represents the number of shares of Precigen common stock sold pursuant to a sell-to-cover transaction to satisfy tax withholding obligations upon the vesting of restricted stock units on May 23, 2026.

Represents the number of shares of Precigen common stock sold pursuant to a sell-to-cover transaction to satisfy tax withholding obligations upon the vesting of restricted stock units on May 23, 2026.

Represents the number of shares of Precigen common stock sold pursuant to a sell-to-cover transaction to satisfy tax withholding obligations upon the vesting of restricted stock units on May 23, 2026.

Represents the number of shares of Precigen common stock sold pursuant to a sell-to-cover transaction to satisfy tax withholding obligations upon the vesting of restricted stock units on May 23, 2026.

Each restricted stock unit ("RSU") represents a contingent right to receive one share of Precigen common stock.

Each restricted stock unit ("RSU") represents a contingent right to receive one share of Precigen common stock.

Each restricted stock unit ("RSU") represents a contingent right to receive one share of Precigen common stock.

Each restricted stock unit ("RSU") represents a contingent right to receive one share of Precigen common stock.

Represents 50% of the RSUs granted on June 26, 2025 that vested on May 23, 2026. The remaining RSUs will vest in equal quarterly installments for three years thereafter.

Each restricted stock unit ("RSU") represents a contingent right to receive one share of Precigen common stock.

Represents 50% of the RSUs granted on June 26, 2025 that vested on May 23, 2026. The remaining RSUs will vest in equal quarterly installments for three years thereafter.

Each restricted stock unit ("RSU") represents a contingent right to receive one share of Precigen common stock.