Avoro Capital Advisors LLC

CIK

1633313

Location

NEW YORK, NY

Portfolio Value

Mid $6,750,104,056

Diversification

Diversified

Filing Date

Global Rank

#547 / 7,976 ▲ 90

Top Industry

Biotechnology 85.1%

3Y Alpha vs SPY

-4.2%

Period ended 9 months ago

Filed Nov 14, 2025 · 7mo

23 quarters · since Mar 2020

Clone Performance

Jun 2023–Jun 2026 · vs SPY

Hypothetical growth of cloning every reported 13F position and rebalancing on each filing, indexed to the same start.

Cloned portfolio

+58.7%

SPY

+76.3%

Annualised alpha

-4.2%

Max drawdown

−30.0%

Estimate. 13F holdings are quarter-lagged and long-only, so the clone rebalances about 45 days after each period end — when the filing becomes public — and excludes options and short positions. Past performance does not predict future results.

Portfolio Concentration

25 positions · as of Sep 30, 2025 · Δ vs Jun 30, 2025

Top Position

15.1%

−2.1 pts

Top 5

59.4%

−3.0 pts

Top 10

82.1%

−1.0 pts

HHI

886

Diversified−67

Portfolio Trend

23 quarters · across all stocks

Sector Breakdown

As of Sep 30, 2025

Sector	% Portfolio	Value	Positions
Healthcare	100.0%	$6,750,104,056	25

Last Quarter's Activity

Export CSV

Sep 30, 2025 vs Jun 30, 2025

Added To

Positions the filer increased

8 positions

Ticker	Company	Δ Shares	Shares	Value
CNTA	Centessa Pharmaceuticals plc	+5,808,080	10,808,080	$262,095,940
OCUL	Ocular Therapeutix, Inc	+2,850,000	10,250,000	$119,822,500
QURE	uniQure N.V.	+819,444	4,444,444	$259,422,196
SLNO	Soleno Therapeutics Inc	+527,777	2,577,777	$174,257,725
ARWR	Arrowhead Pharmaceuticals, Inc.	+300,000	10,900,000	$375,941,000
ASND	Ascendis Pharma A/S	+130,000	5,110,000	$1,015,919,100
KRYS	Krystal Biotech, Inc.	+117,777	2,777,777	$490,360,973
SEPN	Septerna, Inc.	+100,000	1,337,500	$25,158,375
No positions match the current search.

Trimmed

Positions the filer reduced

10 positions

Ticker	Company	Δ Shares	Shares	Value
BCRX	Biocryst Pharmaceuticals Inc	−3,250,000	1,250,000	$9,487,500
FOLD	AMICUS THERAPEUTICS, INC.	−2,975,000	15,025,000	$118,397,000
MLTX	MoonLake Immunotherapeutics	−2,150,000	2,000,000	$14,340,000
MNKD	Mannkind Corp	−1,381,123	4,468,877	$23,997,869
ALKS	Alkermes plc.	−660,000	2,240,000	$67,200,000
KYMR	Kymera Therapeutics, Inc.	−205,555	6,350,000	$359,410,000
ARGX	Argenx SE	−185,000	990,000	$730,184,400
UTHR	UNITED THERAPEUTICS Corp	−147,778	2,222,222	$931,577,684
VERA	Vera Therapeutics, Inc.	−90,000	6,210,000	$180,462,600
MDGL	Madrigal Pharmaceuticals, Inc.	−42,000	1,833,000	$840,723,780
No positions match the current search.

New Positions

Positions the filer opened this quarter

3 positions

Ticker	Company	Shares	Value
GPCR	Structure Therapeutics Inc.	5,405,555	$151,355,540
ORKA	Oruka Therapeutics, Inc.	1,333,340	$25,640,128
TNGX	Tango Therapeutics, Inc.	545,000	$4,578,000
No positions match the current search.

Sold Out

Positions the filer fully exited

2 positions

Ticker	Company	Shares	Value
GLUE	Monte Rosa Therapeutics, Inc.	3,725,000	$16,799,750
RARE	Ultragenyx Pharmaceutical Inc.	330,000	$11,998,800
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

25 positions · $6,750,104,056 total · as of Sep 30, 2025

All sectors Healthcare

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	% of Portfolio
TNGX	Tango Therapeutics, Inc. Healthcare	NEW	545,000	NEW	$4,578,000	NEW	0.07%
WHWK	Whitehawk Therapeutics, Inc. Healthcare	Held	2,849,402	0	$5,413,863	+1.6%	0.08%
BCRX	Biocryst Pharmaceuticals Inc Healthcare	Reduced	1,250,000	-3,250,000	$9,487,500	−76.5%	0.14%
MLTX	MoonLake Immunotherapeutics Healthcare	Reduced	2,000,000	-2,150,000	$14,340,000	−92.7%	0.21%
MNKD	Mannkind Corp Healthcare	Reduced	4,468,877	-1,381,123	$23,997,869	+9.7%	0.36%
SEPN	Septerna, Inc. Healthcare	Added	1,337,500	+100,000	$25,158,375	+92.3%	0.37%
ORKA	Oruka Therapeutics, Inc. Healthcare	NEW	1,333,340	NEW	$25,640,128	NEW	0.38%
ALKS	Alkermes plc. Healthcare	Reduced	2,240,000	-660,000	$67,200,000	−19.0%	1.00%
TSHA	Taysha Gene Therapies, Inc. Healthcare	Held	21,700,000	0	$70,959,000	+41.6%	1.05%
FOLD	AMICUS THERAPEUTICS, INC. Healthcare	Reduced	15,025,000	-2,975,000	$118,397,000	+14.8%	1.75%
OCUL	Ocular Therapeutix, Inc Healthcare	Added	10,250,000	+2,850,000	$119,822,500	+74.5%	1.78%
GPCR	Structure Therapeutics Inc. Healthcare	NEW	5,405,555	NEW	$151,355,540	NEW	2.24%
SLNO	Soleno Therapeutics Inc Healthcare	Reduced	2,577,777	-1,522,223	$174,257,725	−49.3%	2.58%
VERA	Vera Therapeutics, Inc. Healthcare	Reduced	6,210,000	-90,000	$180,462,600	+21.6%	2.67%
XENE	Xenon Pharmaceuticals Inc. Healthcare	Held	5,400,000	0	$216,810,000	+28.3%	3.21%
QURE	uniQure N.V. Healthcare	Added	4,444,444	+819,444	$259,422,196	+413.4%	3.84%
CNTA	Centessa Pharmaceuticals plc Healthcare	Added	10,808,080	+5,808,080	$262,095,940	+298.9%	3.88%
APLS	Apellis Pharmaceuticals, Inc. Healthcare	Held	12,222,222	0	$276,588,883	+30.7%	4.10%
KYMR	Kymera Therapeutics, Inc. Healthcare	Reduced	6,350,000	-205,555	$359,410,000	+25.6%	5.32%
ARWR	Arrowhead Pharmaceuticals, Inc. Healthcare	Added	10,900,000	+300,000	$375,941,000	+124.5%	5.57%
KRYS	Krystal Biotech, Inc. Healthcare	Added	2,777,777	+117,777	$490,360,973	+34.1%	7.26%
ARGX	Argenx SE Healthcare	Reduced	990,000	-185,000	$730,184,400	+12.7%	10.82%
MDGL	Madrigal Pharmaceuticals, Inc. Healthcare	Reduced	1,833,000	-42,000	$840,723,780	+48.2%	12.45%
UTHR	UNITED THERAPEUTICS Corp Healthcare	Reduced	2,222,222	-147,778	$931,577,684	+36.8%	13.80%
ASND	Ascendis Pharma A/S Healthcare	Added	5,110,000	+130,000	$1,015,919,100	+18.2%	15.05%