Thank you for standing by. My name is Gil, and I will be your operator for today's call. At this time, I would like to welcome each and every one of you to the Biorad Second Quarter 2025 Results Conference Call and Webcast. All lines will be placed on mute to prevent any background noise. After the speaker's remarks, there will be a question and answer session. If you would like to ask a question during this time, simply press star followed by the number one on your telephone keypad. If you would like to hear your question, kindly press Star 1 again. It is now my pleasure to turn today's call over to Biorad's Head of Investor Relations, Mr. Edward Trump. Please go ahead.

Good afternoon, everyone, and thank you for joining us. Today, we will review the second quarter 2025 financial results and provide an update on key business trends for Biorad. With me on the call today are Norman Shorts, our Chief Executive Officer, John DiVincenzo, President and Chief Operating Officer, and Rup LaGaraju, Executive Vice President and Chief Financial Officer. Before we begin our review, I'd like to remind everyone that we will be making forward-looking statements about management's goals, plans and expectations, our future financial performance, and other matters. These statements are based on assumptions and expectations of future events that are subject to risks and uncertainties. Our actual results may differ materially from these plans, goals, and expectations. You should not place undue reliance on these forward-looking statements and I encourage you to review our filings with the SEC where we discuss in detail the risk factors in our The company does not intend to update any forward-looking statements made during the call today. Finally, our remarks today will include references to non-GAAP financials, including net income and diluted earnings per share, which are financial measures that are not defined under generally accepted accounting principles. In addition to excluding certain atypical and non-reoccurring items, our non-GAAP financial measures exclude changes in the equity value of our stake in Sartorius AG in order to provide investors with a better understanding of BIRAD's underlying operational performance. Investors should review the reconciliation of these non-GAAP measures to the comparable GAAP results contained in our earnings release. We have also posted a supplemental earnings presentation in the Investor Relations section of our website for your reference. With that, I'll now turn the call over to our Chief Operating Officer, John DiVincenzo.

Thank you, Ed. Good afternoon, everyone, and thank you for joining us today. We are pleased to share our second quarter 2025 results, which reflect solid execution across the business. Both revenue and operating margin exceeded consensus expectations, underscoring the strength of our portfolio and the discipline of our teams in a challenging and rapidly evolving macroeconomic environment. Our clinical diagnostics business remained stable, while our life science segment benefited from the strength in our process chromatography portfolio product mix and a continued focus on cost control and discretionary spending helped drive an outperformance in operating margin for the quarter while we continue to face headwinds in the academic market due to constrained government funding we saw signs of stabilization particularly in consumables this resilience highlights the enduring demand for our differentiated assays and reagents including droplet digital PCR consumables, which saw high single-digit revenue growth versus 2024. The second quarter was a busy one for our DDPCR team, as we completed the development of the QX Continuum platform and successfully closed the acquisition of Stila Technologies, adding new platforms and a fantastic team of colleagues to BioRud. Synchronized with the closing of the Stila acquisition, we launched the rebranded QX700 series DDPCR instruments. The combination of the QX Continuum and QX700 series products are positioned to expand our droplet digital PCR portfolio for customers requiring a simplified workflow and flexibility at various budget levels. Although it is early, customer feedback has been very positive. We look forward to showcasing these innovations at the upcoming DDPCR World Conference in Seoul, Korea this September, along with a series of satellite events across APAC, EMEA, and the Americas. Also during the quarter, several of our key DDPCR partners made progress in bringing this technology to the diagnostic market. InSight Molecular Diagnostics, formerly Oncocyte, announced positive clinical data for its assay and kidney transplant monitoring. We are supporting its path toward FDA approval in 2026 and the development of a kitted IVD solution, an exciting advancement for the transplant community. Geneoscopy advances Colasense colon cancer screening test, which is powered by our DDPCR technology. The assay was recently included in the National Comprehensive Cancer Network Guidelines, a critical enabler for clinical adoption and reimbursement. We are encouraged with their progress and the potential of Colasense. Operationally, our teams continue to drive improvements through strong execution of lean initiatives, careful cost management, and actions to actively mitigate tariff impacts. In diagnostics, strength outside of China helps offset local reimbursement pressures, resulting in 3.7% growth in our rest-of-world markets. In China, volume-based procurement, or VBP, has not impacted our portfolio. Beyond the previously noted diabetes testing reimbursement reductions, we haven't faced any new reimbursement challenges. While we factored headwinds from the recent diagnosis-related group, or DRG, policy changes affecting diagnostic panels into our first quarter guidance, the impact was not significant in the second quarter. Our local team continues to diligently monitor the evolving landscape of Chinese government policies. And finally, I'm excited to welcome Rajat Mehta as Bayrad's new Executive Vice President of Global Commercial Operations. Rajat brings deep experience across diagnostics and life sciences, most recently leading a large regional diagnostics division of LabCorp. He has lived and worked globally and brings expertise in commercial transformation, digital innovation, and customer-centric strategies. Rajat succeeds Mike Crowley, who is retiring after a remarkable 26-year career with Biorad. I have enjoyed working with Mike during my first year and personally thank him for his support. We all wish Mike all the best in his retirement. So thank you again for your continuous support. I'll hand the call over to Roop for a detailed review of our financial results.

Thank you, John, and good afternoon. I'd like to start with a review of the second quarter 2025 results. Overall, we executed well during the quarter. Net sales for the second quarter of 2025 were approximately $652 million, which represents a 2.1% increase on a reported basis versus $638 million in Q2 of 2024. On a currency-neutral basis, this represents a 1% year-over-year increase and was primarily driven by sales of our process chromatography products. Sales of the Life Sciences Group in the second quarter of 2025 were $263 million, compared to $251 million in Q2 of 2024, which is an increase of 4.9% on a reported basis and 3.8% on a currency neutral basis, primarily driven by the increase in process chromatography and food safety product sales. Currency neutral sales increased in the Americas and EMEA, partially offset by decreased sales in Asia Pacific. Our process chromatography business experienced strong double-digit growth on a year-over-year basis due to orders pulled into the second quarter by customers. The orders represented approximately 20% of the quarter's process chromatography sales. Zooming out of the second quarter results, we now expect low double-digit growth for this product area in 2025 versus our prior high single-digit growth outlook. Excluding process chromatography sales, our core life science group revenue decreased 1.7% year-over-year and 2.7% on a currency-neutral basis, reflecting ongoing softness in the biotech and academic research market, which affects instrument demand. Sales of the clinical diagnostics group in the second quarter of 2025 were approximately 389 million compared to 388 million in Q2 of 2024, essentially flat on a reported basis and a decrease of 0.7% on a currency neutral basis. The decrease is because of the previously discussed lower reimbursement rate for diabetes testing in China, partially offset by increased demand for our quality control and immunology products. On a geographic basis, currency-neutral sales decreased in Asia-Pacific, partially offset by increased sales in EMEA and the Americas. Q2 reported gross margin was 53% as compared to 55.6% in the second quarter of 2024. On a non-GAAP basis, second quarter gross margin was 53.7% versus 56.4% in the year-ago period. The decrease in non-GAAP gross margin was due to higher material costs and reduced fixed manufacturing absorption because of lower instrument demand. SG&A expense for the second quarter of 2025 was $208 million, or 31.9% of sales, compared to $195 million, or 30.5% in Q2 of 2024. The second quarter non-GAAP SG&A spend was $201 million versus $194 million in the year-ago period. The year-over-year increase in non-GAAP SG&A expense was primarily due to higher variable compensation costs. Research and development expense in the second quarter on a GAAP and non-GAAP basis was $61 million, or 9.3% of sales, compared to $59 million, or 9.2% of sales in Q2 of 2024. The slightly higher year-over-year R&D was primarily due to project-related spending. Q2 operating income was $77 million, or 11.8% of sales, compared to $101 million, or 15.9% of sales in Q2 of 2024. On a non-GAAP basis, second quarter operating margin was 13.6%, compared to 16.7% in Q2 of 2024, reflecting the lower gross margin. The change in fair market value of equity security holdings, primarily related to the ownership of Sartorius AG shares, contributed $250 million to our reported net income of $318 million, or $11.67 per diluted share. Non-gap net income, which excludes the impact of the change in equity value of Sartorius shares, was $71 million, or $2.61, diluted earnings per share for the second quarter of 25. Moving on to cash flow. For the second quarter of 2025, net cash generated from operating activities was $117 million compared to $98 million for Q2 of 2024. Net capital expenditures for the second quarter of 2025 were $46 million and depreciation and amortization for the second quarter was $41 million. Regarding free cash flow, we were pleased with a generation of $71 million, which compares to $55 million in Q2 of 2024. For the first six months of 2025, we generated free cash flow of $166 million, resulting in a year-to-date free cash flow, a non-GAAP net income conversion ratio of 117%. We continue to target full year of free cash flow of approximately $310 to $330 million for 2025. During June, we purchased an additional 170,860 shares of our stock for total cost of $40 million for an average purchase price of approximately $233 per share on top of the $99 million share repurchase we called out for April. In aggregate, we bought back 593,508 shares during the second quarter for a total cost of $139 million, or an average price of approximately $234 per share. We will continue to be opportunistic with our buyback program and still have $337 million available for share repurchases under the current board-authorized program. Moving on to the non-GAAP guidance for 2025. We are raising our 2025 full-year guide to reflect the Q2 results, the close of the still acquisition, the evolving state of academic and biotech research funding, and the impact of changes in the macroeconomy, including tariffs. Overall, we now expect total currency neutral revenue to be in the range of flat to 1% growth with a midpoint approximately 25 basis points higher than our previous guides. With respect to our life science business, we see consumable demand from academic customers more durable than our prior expectations, in addition to an improved outlook for our process chromatography business that I called out earlier. With the recent close of the still acquisition, we now expect revenue for our DDPCR portfolio to increase mid single digit in 2025 versus low single digit previously. We continue to see a slow biotech recovery and soft demand for instruments. In aggregate, we now expect our life science business to increase in the range of flat to 1% for the full year versus flat to down 3% previously. For our diagnostics, business, we are further tightening our range to approximately growth of 0.5 to 1.5 percent for 2025 versus 0.5 to 2.5 percent previously. This represents a 50 basis point reduction at the midpoint and primarily reflects continued market softness. Reflecting the easing of trade tensions with China and delays in implementing tariffs in other regions, we now expect a reduced headwind of approximately 30 to 40 basis points to operating margin. The remaining tariff headwinds are primarily related to supplier costs and EU manufactured products that are imported to the US. Factoring in the reduced tariff headwind, the updated full-year non-GAAP gross margin is projected to be between 53.5% and 54.5% versus 53% and 54.5% previously. Full-year non-GAAP operating margin is now projected to be between 12 and 13 percent versus 10 and 12 percent previously, reflecting our updated gross margin outlook along with proactive cost actions we've taken in managing the business. We continue to anticipate incurring an IPR&D expense in the third quarter as previously disclosed. Due to a further weakening of the U.S. dollar, we now expect currency exchange to be approximately a 100 basis point tailwind to 2025 revenue with a 10 basis point positive impact on operating income. Notwithstanding our updated outlook for 2025, there are still many moving pieces which we continue to monitor closely. Finally, we have previously mentioned having an investor day this November. However, after careful consideration of the continued market volatility and the global geopolitical status, we've decided to move our investor date in the spring of 2026. We will provide more detail on a specific date in early 2026. I'll now turn the call over to Norman for his remarks.

Thanks, Ru. You know, I think as we all know, the second quarter remained tumultuous, but it does seem we're all getting used to it uh for what it's worth uh you know i think uh you know in any case it's good to see our customers adapting to the current situation and figuring out how to navigate uh and you know it's nice to see some positive signals relating to to nih funding for for 2026. you know we discussed tariffs obviously it's still evolving. The U.S. government policies are a work in process, but I think to the credit and determination of Biorett employees around the world, you know, as a company we remain resilient and continue to advance our business on many fronts. Probably good to take a moment here to welcome the still employees to buy a rad I've had the chance to interact with some of them in the last few weeks and and I think they are a great addition to buyer at as John mentioned Mike Crowley who's been leading our global commercial operations is retiring after a long and distinguished career at Biorad. Mike has been an important part of Biorad's success over the years. Just to call out, thank you, Mike, for all your contributions. So I think that concludes our prepared remarks. Gail, I think we'll now open it up to take questions.

This time, I would like to remind everyone that in order to ask a question, press store, then the number one on your telephone key. We will pause for just a moment to compile the Q&A roster. Okay, so your first question comes from the line of Patrick Donnelly with CT. Your line is open.

Hey, guys. Thank you for taking the questions. Maybe first, hey, Rup, how are you? Maybe first, just on the process Chrome side, you know, nice to see those results this quarter. I think you hinted at maybe a little bit of pull forward. Can you just talk about, I guess, what you saw in the quarter, what sense you have for how much of that was pulled forward, what's sustainable. Just want to talk through, you know, given what's going on with tariffs and everything, it felt like maybe there was a little bit of an impact there. So it'd be helpful if you could just talk through that and the expectations for the remainder of the year on that piece.

Yeah, of course. So first of all, I'll start out with maybe for the full year, we actually raised kind of a previous guide on Process Chrome from high single digits to low double digits. So I think that maybe answers your question on sustainability. We think it is sustainable. Yes, we've had both in Q1 and Q2 a little bit of movement between quarters because these are customer conversations where they want to pull it forward for their own purposes. Can't necessarily say it's because of tariff related. That's not necessarily the driver, but just in terms of their production timeframes and these sort of things. So we were more than happy to help support it. And as I said earlier, I think we see that as continuing to sustain through the rest of the year and expect it to be still good for us.

Okay, understood. And then in the guidance, I just wanted to clean up. I know Stila is now in the guidance. Can you just peel back what contribution that is to the organic number move? I just want to make sure I understand where the raise came from, what's organic, what's If you could just help us out there, it would be appreciated.

Yeah, so we've got a few different reasons. So Stila is now in the guide. as we had indicated, we would once we closed that transaction, which we did as of June 30th. So that's in there. So when we take the guide up, included in there is the DDPCR growth rate moving up to that mid-single digits that we talked about. That movement is solely STILA specific because continuum we already had in our original guide coming into the year because we expected it to be released in 2025, although we didn't specifically give dates, as you know. So that piece is in there, and that contributes to that DDPCR growth rate increase, which obviously then takes our range up overall to that 0 to 1 percent versus the previous wider range that we had, including the down to the minus 3 percent. And so maybe just to summarize, right, so there's Process Chrome, which we just talked about in terms of increased growth opportunity uh the ddpcr including stilla and then the third piece of consumables which have continued to be more durable which we commented on uh during the script yeah that's helpful um and then maybe last one just on the margins you know obviously a lot a lot of moving pieces there with you know some of the tariff moves can you just talk about again the delta you know the bridge from the old guide to the new what are the moving pieces what's tariffs if not, would be helpful.

Thanks, Ruben.

Yeah, of course. So, the biggest piece, tariffs have come down significantly. So, that's a big piece, right? If you remember in the prior calls, we didn't get it. We could see up to 130 points of headwind on tariffs at the bottom line. We now think that that's 30 to 40 bps of headwind on the off margin related to tariffs. So, significant change there. So, if you think about the off margin change from 10 to 12 percent previously to now the 12 to 13 percent you can see about 100 bits of that is related to tariffs the rest of it is related to one uh expecting to see because of stilla and and other things uh some better absorption uh from the manufacturing standpoint and then of course the mix continuing to be um uh stable for us and and uh positive if you will because the consumable pulled through So, those are the different pieces there.

Your next question comes from the line of Dan Leonard with UBS. Your line is open.

Thank you very much. My first question is on the diagnostics market in China. I could use a bit of help understanding how all the headlines relate or don't relate to BioRat over there and why.

Yeah, maybe I can start, John. Please jump in. Norman, jump in. And so I guess there's three pieces if you think about right now. I mean, China still overall is soft, so I'll start with that. So maybe that's four pieces. So that's number one, China's continuing to be soft. With that said, I think in terms of some of the elements that, you know, John mentioned, I think, in his part of the script, you know, VBP, we've not seen any impact of VBP, and we continue to not see impact from VBP. So that's not something we've seen. You mentioned DRG. That's something we actually saw earlier in the year. And, Dan, if you remember, we actually indicated that we took our numbers down during the Q1 call for the rest of the year because of some softness in diagnostics. Part of that was some of this China DRG piece that was in there. So, we'd already contemplated that. And, you know, we haven't seen any significant change or change from what we've commented on back then. The final piece is around the reimbursement rate changes. I mean, it's something our teams continue to monitor, as John said, but we haven't seen any news that we've got further reimbursement rate changes that could negatively impact us.

Yeah, exactly, Ruben. And I think, again, this is John DiVincenzo. Essentially, it reflects our mix versus maybe some other suppliers. We're a specialty diagnostic supplier. A large part of our portfolio are quality controls, which are not necessarily affected by reimbursement. And then the other areas that we, you know, called out, yes, we were affected by the diabetes reimbursement, but other areas, specialty areas, are not really targeted at this time by those policies. So I just think it's where they've looked at the bigger spend, the larger maybe areas there, and it has not affected us, and we don't think that it's part of their view moving forward.

And, John, on the panel testing pressures over there, I know you supply panel tests through the Bioplex 2200, but from a mixed perspective, is that just not a big part of your mix in China?

Right, exactly. I think that's the explanation, yeah.

And then for my follow-up question on the tariff environment, I appreciate that there is lesser operating margin headwind due to the rollbacks. I'm wondering if I'm wondering how more. How are you managing your business, given all the uncertainty? Are there actual countermeasures you've put in place for a more severe tariff environment that you've had to roll back? Or are there things that are in flight which remain in flight? If you could just talk through the that process a little bit for me, that would help. Thank you.

Yeah, so we have taken a number of actions. Obviously, we've taken a fine, fine look at all of our different supply suppliers across various geographies. We have already started to move some of the way we move materials around the world where we make product. We have plans in place to even be more flexible in the future and adapt to, you know, what's the best source of those products. So we've worked with suppliers. We've worked with our own teams. We've built, you know, replicated in some areas some manufacturing capabilities if it becomes necessary. We didn't want to overdo it because of all the volatility still out there. But as things settle down now, we think we're in pretty good shape where we know where the challenges are. We have some flexibility from our suppliers. and we have flexibility in our own plants to move manufacturing around. So we feel like, you know, as much as we could be, we have some adaptability there and some resilience.

Thank you very much.

Thanks, Dan.

Your next question comes from the line of Brandon Cuyar with Wells Fargo. Your line is open.

Nice question. Ruth, as we look at the second half, How should we think about revenue margin phasing between third and fourth quarter, and did the second half organic guide actually come down if we exclude the STILA contribution?

No, it did not organically. I mean, we've got some headwind in the Diagon continue to be inclusive of STILA and is helping support kind of that overall increase, if you will. So in terms of profiling, you know, I think Q3 is going to look similar to Q2 from a top-line perspective. And then, of course, we've got the fourth quarter with seasonal increase that we expect to see. So we may see a little bit of strength in Q3 over Q2, but not much. But then we've got Q4 stepping up, you know, kind of reasonably, although probably not as much as what we saw before. I think some of that's moved around a little bit into whether it's Q3 and Q2, et cetera, from an overall profiling standpoint. From a margin standpoint, what you're going to end up seeing is Q3 margins being somewhere in the similar range of Q2 and then in Q4 because we do have part of it's the mix with higher quality systems and some of the DDPCR flow through Q4 margins and then the improved absorption um to be better than raw standpoint to land within kind of that midpoint of of the range of what we provided the 53 and a half percent to 54 and a half percent and we spend quite a bit of

time with our commercial teams and customers uh to look at that ramp that we have in the fourth quarter fourth quarter is a significant increase over the previous few quarters there but it's a little bit of timing and it's kind of year over year we see a number of areas of our business have larger orders and we have both high confidence in the orders coming through as well as all of our supply teams to be able to deliver that product during the quarter. So pretty good confidence level in the fourth quarter number as well.

Okay, thanks. That's helpful. On DDPCR, did you comment on how instruments performed in the quarter? And then secondly, it's nice to see Continuum finally coming to market.

I think you mentioned that it was already baked into the guidance but do you think there's any pent-up demand in the market for uh that system and how are you kind of positioning it relative to the distilla uh platforms thank you yeah so um i i you know recognize the team did a great job not only kind of getting to the finish line and closing uh the acquisition but you know keeping that focus on continuum and and having very robust quality data to be able to launch that into the marketplace there's a lot of excitement about it I mean, the Continuum platform was designed to replace QPCR. It's a 96-well-played standard format, and there's a lot of excitement about that, you know, bringing more precision sensitivity to those applications. So a lot of excitement there. So we're kind of on track to what we had kind of forecasted going into the year. On the QX700 series, you know, the team's already rebranded them, positioned them. We're moving, you know, we have hundreds of thousands of assays that have been developed over the last decade or so. We're moving those on to Continuum and to the QX700. So, you know, a week after we closed the deal, we had our sales team in Pleasanton, California, being trained on them. And we continue that training globally, both in sales and service. So we're doing everything possible to drive, share, and expand overall the market for digital PCR. So a lot of excitement for both those products coming to the market. on our assay content.

Any color on just how instruments, DDPs or instruments performed in 2Q?

Yeah, they were, I mean, on a sequential basis, they were slightly better, but on a year-over-year basis, it was relatively weak overall.

Still very soft, particularly in the academic market where people are not sure of their budgets overall. So we see softness across the board, instruments, not just digital PCR, but all the other instruments as well. yeah right thanks we and you know just a little bit of color that we we have not factored in any kind of end of year budget flush um but potentially that's some upside for us as we we uh speak to customers on a daily basis here and potentially they'll be a little more confidence in their budget and there could be a little bit upside but we have not factored into our forecast your next question comes from the line of jack mehan with not from research your line is open Good afternoon.

Hi, everyone. First question, wanted to ask about the process Chrome strength in the quarter. How much of this is just small numbers and easy comps versus can you talk about what you're seeing in terms of order patterns with your customers and any recovery there?

Yeah, so I think we're getting back to a normal state where it's not a matter of, you know, customers being overstocked anymore. That'd be some of that in some places, but I think it's more of an appropriate relationship between how they need product, when they need product, and when they're ordering from us. So you're right, it's an easier comp. Last year was a soft year as we allowed our customers to adjust to kind of their inventory levels they wanted, and now we think it's more of a direct correlation between their demand and what they're ordering from us, and it's more similar to the volume that we saw, you know, in years past, before kind of the volatility of supply chain challenges and overall their own managing their inventory.

Okay and then sticking with life sciences you call that food safety as a growth driver it's been a while since we talked about that product family anything to note there?

You know our food safety business is an interesting one because we're essentially taking our products that are used in life science research and either developing specific content for the food applications and and that area continues to grow high single digit we have a very strong team focused on that it's not a huge business for us but it is an interesting kind of additional market applied market that do not have some of the challenges that we see today in life sciences or in biotech so it's you know it's an area that we're looking to see what more could we do there the next few years.

Okay. And last one, I wanted to circle back on the U.S. federally funded research customers. Just as you look at them as a customer class, can you talk about how the demand played out throughout the quarter on consumables and instruments? Was it stable to strengthen or weaken at all? How are you feeling about that?

Yeah, Jack, it was stable throughout the quarter and improved from where it was in Q1 where I think there was a bit more and to see that Okay, thank you guys Your next question comes from the line of Tycho Peterson with Jeffries Your line is open Thanks as Matt on for Tycho Rube, to go back to Process Chrome just appreciate the disclosures in the deck you guys here this quarter

but it seems to suggest that on a dollar basis Process Chrome was up like $15-16 million dollars year over year are you saying 20 percent of that is tied to pull forward so maybe a few million was pulled forward and then any more color you can provide on just the strong double digit growth just given the revenue base of that business you know and those disclosures I mean that would suggest that the strong double digits was something like 50 percent plus in the quarter so any more clarity you can just add in terms of the magnitude of the process chrome growth and and the comp you had in check here.

We like your hat. I know, Matt, you got a lot of, I appreciate all the numbers there. Listen, I think you're a little high on some of those numbers. So when we think about Process Chrome and where it landed for the quarter, you know, obviously we've got an easy comp from a 24 standpoint. And as we've talked about, we've got, I think, as John said, a more, you know, normalized environment so so that's that's been a good on a sequential basis we saw strength on process chrome uh as a result and and obviously a very strong compare on a year-over-year basis um it's not quite 50 on a year-over-year um it's kind of you know maybe closer to half that or slightly above half of that sort of number that's how you ought to think about it okay thanks that's helpful um and then just to go back to the the new digital pcr launch it sounds like you have the whole team out there right after it closed.

Can you just talk about what you're doing on the commercial side to stimulate demand? Are you running any promotions for existing DDPCR customers? I understand it's a different part of the market. Or are you running any kind of targeted programs for high-end QPCR customers? Just talk about how you're kind of positioning the 700 series in the continuum going forward.

Yeah, and we will share more details at a webinar coming up here, but it's exactly the point is that this is not to replace our small base. It's really to expand the number of users for digital PCR. It is a very simple workflow at the right kind of price point to take share from QPCR. It also, as you said, on the high end, you know, with the QX700 HT and our existing QX600 products, we continue to have the high sensitivity products in the market, and we see a number of applications where, you know, rather than next-gen sequencing, they can apply digital PCR for kind of faster and less expensive solutions for them. So it's expansion of the marketplace primarily. Of course, there's some areas where it'll hit kind of the center of the existing DDPCR market, but in general, it's to expand the number of users of Droplet Digital PCR.

Thank you. Maybe if I could sneak one more in. OUS, academic government, we'd just be curious kind of what demand trends look like both in Asia and Europe and 2Q and kind of how you're thinking about the funding and demand backdrop, XUS, for ANG for the rest of the year. Thank you.

Maybe Ruth will give more details on it, but when we say academic, we're specifically talking about global academic, where some countries in Europe have shifted budgets to defense or other areas, you know, it's a zero-sum game in some areas, so they're slowing down some investments in academic. So it's not just a U.S. phenomena, it's a global phenomena. I can't say I know exactly in China if it's really seen that way or not, but certainly U.S. and Europe are similar in pressures on academic funding.

I think you're spot on, John. And just from an AIPAC standpoint, China is continuing to be soft. We're seeing some movement, positive movement in Korea and Japan, which is great to see because they've been kind of jammed up for a bit of time now. But China is kind of in that softness category, if you will.

Thank you, everyone.

From an academic standpoint, just to reiterate what we said, you know, our customers are focused on keeping their people and keeping the research going. So I actually commend them for their ingenuity in making that happen. But it shows in our results for our assays and reagents that are continuing to be used. We can see the research is continuing. Even in uncertainty, you know, they're moving science forward. And I think it's commendable that with all the disruptions and unknowns, that they continue to do that. We see that in our numbers.

Okay, so your next question comes from the line of Connor McNaira with RBC. Your line is open.

Hi, this is David Carter for Connor. I just wanted to call to ask about, can you confirm if the organic number 423, which goes from like a negative three, that goes to about positive 5% in the fourth quarter?

That sounds about right, because you're looking at it from a total company standpoint, is that right?

Yeah, that's correct.

Yeah, so that's right in terms of how that progresses through the year.

And again, part of that is in the fourth quarter last year is when we first saw the reimbursement changes in China. So that's annualized at that point in time. So, you know, that's kind of not necessarily because all of a sudden there's a better market dynamic. It's more of a comp to it.

And just to follow up on the continuum, how has the response been for the lower throughput customers? That was one aspect of the portfolio. There was a gap for that for the DDPTR. How is the uptake from that portion of customers?

Yeah, I think it's too early to give you actual results, but actually the flexibility on the continuum where you can have one sample or 96 samples is cost-effective and it also meets those customers, you know, more episodic when they're actually using the platform. So that's one of the advantages that we're touting to the product, but probably a little too early to tell that there's direct customer user feedback yet. Give us a month or so.

Okay, still early rounds, no problem.

Thank you.

Jose Ricardo.

Thank you, everyone. And that concludes our Q&A session for today. I will now turn the call back over to Mr. Edward Chung for the closing remarks. Please go ahead.

Thank you for joining today's call. As previously discussed, we are planning to host a webinar on Droplet Digital PCR and our updated portfolio on August 26th at 1 p.m. Eastern Time, 10 a.m. Pacific. We will post registration information on the Investor Relations section of Biorad.com shortly. As for upcoming investor conferences this fall, we'll be participating at the Wells Fargo Healthcare Conference in Boston and the Morgan Stanley Global Healthcare Conference in New York. Our CEO, Norman Schwartz, will also be participating on an industry panel at the Nefron Healthcare Summit in NAPA. As always, we appreciate your interest, and we look forward to connecting soon.

Ladies and gentlemen, that concludes today's call. Thank you all for joining and you may now disconnect. Have a nice day ahead, everyone.