Good evening. I'm Daniel Marshall, Senior Manager of Communications and Ownership. It's my third year here at Ginkgo. I've spent much of that time working behind the scenes with our investor relations team on these earnings calls, but I'm thrilled to be joining you for the first time live on air. I'm joined by Jason Kelly, our co-founder and CEO, and Mark Dimitrik, our CFO. Thanks as always for joining us. We're looking forward to updating you on our progress. As a reminder, during the presentation today, we'll be making forward-looking statements which involve risks and uncertainties. Please refer to our filings with the SEC to learn more about these risks and uncertainties, including our most recent 10K. Today, in addition to updating you on the quarter results, we're going to provide updates on our path towards adjusted EBITDA break-even, traction with our government clients, as well as new offerings and opportunities emerging for our tools businesses. As usual, we'll end with a Q&A session, and I'll take questions from analysts, investors, and the public. You can submit those questions to us in advance via X, hashtag GinkgoResults, or email investors at ginkgobioworks.com. All right, over to you, Jason.

Thanks, Daniel. We always start off with our mission here at Ginkgo, which is to make biology easier to engineer. And then we had three objectives, and I first showed these, or close variants of these, about a year ago when we announced that we're going to be doing a major restructuring of the company. And these three objectives were to reach adjusted EBITDA break-even by the end of 2026, and importantly, doing that while maintaining a cash margin of safety. In other words, we didn't want to get in a position where we were going to need to fundraise when we didn't want to, right? We wanted to be doing that if we needed to fundraise from a position of strength, but ideally not even need to fundraise. Second, we wanted to cut cost while, importantly, serving our current customers. We had a lot of amazing customers large pharmas large ag biotechs industrial biotechs as well as the government we wanted to keep serving those customers well while at the same time focusing the company and then finally we wanted to expand the way we sold our platform and i'll talk more about this in the strategic section but from not just r d solutions where we do an end-to-end research project but also directly as a tools business like a traditional cro or an equipment vendor would These were new ways to go to market to a wider set of potential customers than we had with our solutions business. So those were our three objectives. And I'm very happy to say we made progress on all of them. But after a year, we've just made unbelievable progress on taking out costs while still serving our customers. So, you know, I'm very happy to say we're at a $205 million reduction in our annual run rate between Q1 2024 and Q1 2025. You might remember the target I had set was 200 million, I think, by Q3 or something of this year, you know, like halfway through this year. We already beat that. We're moving. We've taken actions in the first quarter that are going to improve this even further, Markle mentioned. And so I really think this sets us up to be in an incredibly strong position. And importantly, because we did it faster, we're at this place while still having, you know, $517 million in cash and cash equivalents on the balance sheet and no bank debt. So that among our peers in sort of the advanced sort of platform technology space in the market today, I think is a uniquely strong position. And look, biotech on the capital market is going through a tough time right now. that is challenging for the companies in it it's also opportunity i would say for investors and from my standpoint the companies that can make it out the other side of that are in a particularly strong position uh as since biotechnology is you know i think a fundamental industry that's not going away and so uh this sets us up to be in a place to do that and i want to be just you know give my thanks to the team for what's been an incredibly uh difficult challenging ton of work last year to get us to where we are but it puts us in a very very strong spot uh going forward so with that i'm going to hand it to mark to go off over this quarter's financials thanks jason

i'll start with the cell engineering business cell engineering revenue was 38 million dollars in the first quarter of 2025 up 37 compared to the first quarter of 2024. the first quarter this year included $7.5 million in non-cash revenue from a release of deferred revenue relating to the mutual termination of a customer agreement we had with Biome Edit, one of our platform ventures. Excluding this impact, cell engineering revenue was $31 million, up 10% compared to the first quarter of 2024. This increase was primarily driven by strong growth with biopharma and government customers in the first quarter of 2025 we supported a total of 123 revenue generating programs on the cell engineering platform this represents a 32 increase in revenue generating programs year over year as discussed on our last earnings call this quarter represents the first time we are reporting the new revenue generating program metric and are no longer reporting the original program metrics. As a reminder on the rationale here, the nature of programs that we take on with our customers has evolved significantly following our adjustments to commercial terms and the launch of our tools offerings in 2024. This new metric includes all programs that generated meaningful revenue in the quarter, including smaller programs that were previously reported as other contracts, and further excludes programs that did not generate meaningful revenue in the quarter, which typically would be those programs either just starting or in final stages of completion. We believe the new metric will be more useful to analysts who are using this to model revenue. We have also updated the 2024 comparables using this new metric in the appendix. Now, turning to biosecurity, our biosecurity business generated $10 million of revenue in the first quarter of 2025 at a segment gross margin of 28%. Segment gross margin excludes stock-based compensation. turning to the next slide i'll provide more commentary on key items for the rest of the pnl now that we are almost a year into our restructuring you can see the very substantial cost reductions and improvements in profitability that we have executed when compared to the first quarter of 2024. as a reminder a full reconciliation between segment operating loss adjusted EBITDA, and gap net loss can be found in the appendix. Starting with the more significant items in segment OpEx. In the first quarter of 2025, cell engineering R&D expense decreased 41% from $82 million in the first quarter of 2024 to $49 million in the first quarter of 2025. Cell engineering G&A expense decreased 53% from $38 million in the first quarter of 2024 to $18 million in the first quarter of 2025. And while smaller in amount, you can also see a decrease in biosecurity operating expenses by 33% year over year. All these decreases were driven by our restructuring efforts. Net loss. It is important to note that our net loss includes a number of non-cash income and or expenses as detailed more fully in our financial statements. Because of these non-cash and other non-recurring items, we believe adjusted EBITDA is a more indicative measure of our profitability. And we are now showing you adjusted EBITDA at the segment level so that you can more clearly see the relative profitability of cell engineering and biosecurity. The significant improvement in cell engineering segment operating loss in the first quarter of 2025 compared to the comparable prior year period was due to the previously discussed drivers of improved revenue and reduced operating expenses as well as the non-cash deferred revenue release within the quarter biosecurity segment operating loss also improved significantly due to the primarily cost reduction efforts moving further down the page you'll note that total company adjusted evita in the first quarter of 2025 was negative $47 million, which was up from negative $117 million in the first quarter of 2024. The principal differences between segment operating loss and total company adjusted EBITDA in the first quarter relates to the carrying cost of excess lease space, which you can see was $12 million in Q1 this year. This cost represents the base rent and other charges relating to leased space, which we are not occupying, net of sublease income. We'll continue to break that out for you going forward, since that is a cash operating cost that is not related to driving revenue right now and can be potentially mitigated through subleasing. And finally, I'll just make one additional comment relating to cash burn in the quarter. Cash burn in the first quarter of 2025 was $58 million, down from $104 million in the first quarter of 2024. This significant decrease in cash burn was a result of the restructuring. We expect to further reduce the cash burn run rate significantly from this level by the fourth quarter of 2025, though we expect some lumpiness in the progression during the year due to timing of working capital. In terms of outlook for the full year, we previously issued guidance for total revenue of $160 to $180 million, cell engineering services revenue of $110 to $130 million, and biosecurity revenue of at least $50 million. We update this previously issued guidance solely to reflect the impact of the previously mentioned $7.5 million non-cash deferred revenue release in the first quarter. With this in mind, we now expect our total revenue to be $167 to $187 million, cell engineering revenue to be $117 to $137 million, and biosecurity to remain the same of at least $50 million. In conclusion, we're pleased with the substantial improvements in cash burn and profitability when looking back over the past year. In the first quarter, we continued to execute against our core objectives while navigating significant uncertainty in the macro environment. And with that, I will hand it back over to you, Jason.

Thanks, Mark. So in the strategic section, we're going to cover three topics today. The first, I want to touch again on our continued restructuring efforts and how well that's going on the cash takeout side and our path to sort of EBITDA break even by the end of next year. Second, there's been a lot of changes in the administration and the U.S. government here in terms of sort of approach to research spending and biosecurity and things like that. And I want to just highlight that I think biotech remains a critical emerging tech in the U.S. and that Ginkgo is well positioned for it. And then the third topic, I want to talk about our tools businesses, data points and automation. This has been our big motion over the last year is expanding into the tool space, and that's going really well, and I want to give an update on that. Okay, so first, you know, I talked earlier, I'm really happy to, you know, I have that highlighted in the middle of that $205 million of annualized run rate cost takeout that we've achieved in the year since we announced the restructuring. Our goal, of course, is to get to adjusted EBITDA break-even in 2026. And so I really like this chart on the left. You can see, you know, back in Q1 2024, where we were on the cash expenses and total revenues. And what we want to do is just shrink that gray bar and grow the green bar and eventually get those to be the same size. And so we are pushing it. That is sort of the relentless focus here on the team. Again, I'm really happy to see the progress. It's going in the right direction. We already have made changes in the first quarter that you'll see reflected in the coming quarters to continue to take costs out. And hopefully our efforts in the tool space will keep growing sales as well. I will mention if you look and see the segment breakout here, you know, in biosecurity, again, Q1 2024, or Q4 2024 to Q1 2025, we're at $5 million on a run rate burn. that's that's one where we're hoping to really get biosecurity to break even this year and then cell engineering you can see the enormous progress we've made since q1 of 2024 over last year but I need to continue squeezing on on that in order to reach adjusted even to break even next year so I think we've got a path to it it will be a serious amount of work but I've been extraordinarily impressed and again kudos to the team here at Ginkgo and all the work to date to get to the strong position we're in today and again I don't have it on these slides here but over half a billion dollars in cash in the bank. This has been a tough market for biotechnology. The companies, I think, that make it out the other side of it will be in an especially strong position. And so the fact that we're so well shored up is thanks to the team's efforts over the last year. All right. Next, I want to talk about the new administration and what the U.S. government is doing in biotechnology and biosecurity. There was actually a great speech. I really encourage you to either watch it or read it um uh from um the president's science advisor michael kratios uh it's a cabinet position as of the last administration was turned into a cabinet position uh and he had a great uh speech where he talked about sort of how the administration was going to invest in technology and science and he said whether in ai quantum biotech or next-gen semiconductors uh it's the duty of the government to enable scientists to create new theories and power engineers to put them into practice and so what's important there is that's your short list of critical technologies for the us ai quantum biotech and chips all right so it's good to see biotech on that list it's been on the list uh for a while certainly in the last administration as well um and so i'm happy to see it it's still there um uh from the president's science advisor um this is uh a report that came out you might remember i was actually uh sharing this commission i'm very thankful that uh senator young is now the chair that's a load off me uh and uh michelle rosa the vice chair the final report from this national security commission on emerging biotech uh just came out a few weeks ago i highly encourage folks to read it just a quote here we stand at the edge of a new industrial revolution one that depends on our ability to engineer biology so this is a bipartisan commission obviously senator young's republican uh i see again a push here uh really coming on the legislative side uh for improved you know, reduction in regulations, new sources of funding. I think you will see this administration fund things differently than the previous administration, but I think you will still see funds continue to go out the door towards biotechnology. And importantly, our solutions business at Ginkgo is a trusted R&D service provider to the U.S. government. So we have 28 government projects across both cell engineering and biosecurity, about 180 million plus of contracted backlog or unfunded potential backlog. These are sort of like options on some of our contracts, depending on how things go. And just to highlight a couple wins since President Trump's election, we won a grant called ARPA-H React. This is in partnership with Carnegie Mellon, about a $9 million program sort of for bioelectronic devices in disease treatment. But then I really wanted to highlight a new program we just announced a few weeks ago called WHEAT. It's a $29 million funded program. And if you go to the next slide, the cool about it is you are able to essentially take that wheat germ extract, which has all the components, like the low-level components of cells, right? So this is part of the magic of biology. Our cells, wheat cells, insect cells, bacterial cells, at the lowest level, the DNA, the ribosomes, the mRNA, that's all the same. And so you could actually reuse the material that comes from that wheat germ, add in a piece of DNA that, say, encodes for human insulin or another therapeutic, and then in that cell-free system, in that extract, actually produce that therapeutic drug. And this is not a technology that's coming out tomorrow, but this is a much lower cost source for this sort of cell-free extract than what you can currently get on the market today if we're able to be successful in this research project for ARPA-Age. And so this is the kind of stuff I think is, obviously, I'm excited that we're being a part of this, but I'm just glad to see the government funding this. And this is the type of thing that Ginkgo Solutions business, where we do these end-to-end projects and deliver a scientific result, this is an example of where we're doing that for the US government. And I expect we'll see more of those. Okay, so I want to talk a little bit now about Ginkgo Biosecurity, which is the other big area where we work with U.S. government. We really have two big offerings, product offerings here. The first we call Canopy. And you might remember, we, I'm not going to go into great detail, but we collect wastewater from planes, inbound planes into international airports. We collect metadata. Where did that plane come from? And then we look in the wastewater for a whole panel. I think we're up to like 60 now different infectious diseases. If we see them, then like if we see a virus, we can sequence it and get that variants genomes. Remember all the COVID variants? We can get the variant sequence and then give that back to, you know, the government or whoever is having us do that particular work. And so that's the actual physical collection of data. And then our Horizon platform is when we take all that data and we try to give actionable information back to decision makers. And you can imagine there's a lot of great opportunities for AI and sort of automated learning and data parsing there on the Horizon platform. These types of we think of these like almost like radar stations for monitoring for infectious disease. I mentioned airports, but absolutely, we should be doing this on ships, should be doing this at mass gatherings, military installations, embassies, BSL three and four labs. Like this is a very obvious thing to me, like we ought to be monitoring the effluent, like what's coming out of these labs and the surrounding area around these labs just to, you know, to keep an eye out if there's a leak or things like that. This type of really we consider it passive monitoring, like you're just looking all the time, we think is going to be actually critical in terms of having a strong biosecurity defense network here in the United States. And I think this is particularly salient coming up because, as you know, the United States has stepped out of the WHO. And if you look at how the WHO did its work, that was based on voluntary information sharing. So in other words, you know, there'd be an outbreak in a country and that country's equivalent of the CDC would share that information back with the WHO, WHO would disseminate information globally. I think that's getting outdated in this era. One, you know, there's a lot less cooperation among countries at the moment. Number two, post-COVID, it's very clear the economic impact of these things. So once a country has an outbreak, they got to, there's often a reticence to share that information. We even saw that with COVID itself. And also the technology has just changed a lot in the last 20 years. And passive monitoring, like I talked about in the last couple slides, can turn like a political problem, where you have to ask people for things and have the politics to have them give it to you, into a technological problem, where we're just looking. And if something happens, we see it. And just to be clear, that's how we approach cybersecurity. That's how we approach missile defense. We don't ask, you know, did you launch a missile? We have the satellites up there looking all the time for them. And that's really how we should move to a platform like that for monitoring infectious disease. And I'm hopeful there'll be opportunities to do that as the U.S. considers how to build our infrastructure outside of the WHO. show okay um I want to now talk about uh Ginkgo's data points uh and automation offerings uh where I see new deals and opportunities emerging okay so um uh so about a year ago I showed this slide for the first time uh so Ginkgo's historical uh the way we brought our platform to customers was through what we call solutions where our customer is really the head of R&D so this is the um person who is in charge of say drug development at a company like merck or pfizer and over nord as some of our customers and ginkgo is an outsourced uh scientific team with access to a highly automated unique platform here in the 200 000 square foot lab over here next to me in boston and we would give that customer back a scientific result so a good example is that wheat program i just mentioned The customer there is a program manager, sort of a head of R&D for the government at ARPAH, and our job is to give them back a scientific result over a period of, you know, one to two years with milestones along the way. Very similar to our commercial relationships. All right. About a year ago, we said, hey, we're going to keep doing that. We're going to do it in a more focused set of areas. That's a lot of how we took the cost down. But we're also going to start offering that very same platform, the same robotics, the same integrated systems directly to customer scientists. OK, to the many scientists that are at an Open Nordisk or a Merck and give them tools so that they could do the job of scientific discovery. And that was a new way to go to market. You know, I really like this chart, this curve here. I've shown this before. but on the y-axis the idea here is uh as you go up the axis you have increased customization and technical risk for the customer and the reason i'm highlighting this is because there's sort of a business model shift in the middle of this chart so at the extreme left end of this i'm designing a custom drug i'm taking all the risk on it and i'm hoping that when i get great phase two results or phase three results i can sell it to a large pharma company i make an enormous amount of value. All right. But I take a lot of risk and it's very custom. As you go down the chart, you have our research solutions business. So we are doing custom work. Like every one of these customer projects is different. And it is a technical risk. Like we get paid if we are successful and we hit certain technical milestones. And so as a result, we're able to get royalties and milestones. We're able to get a piece of the customer's product revenue, essentially, Okay, in one form or another. That's sort of on the left hand side of that dotted green line. On the right hand side, you have our tools offerings. And here, we are not taking a royalty, we're not taking any milestones from the customer. And what we're really offering is sort of fee for service work for that customer, so that they can ultimately develop their own products. and that's either going to market with sort of a traditional like CRO style business model with data points or via an equipment business model with automation and you know this really does change if you go the next slide you know the solutions business is really based on sort of longer term but bigger upside per project you know we're getting a piece of that long that you know drug value for example in the long run it just takes a long time the advantage of our tools business is its near-term fees it's a faster sale cycle and we have many many more uh potential customers for that product in any organization uh and the reason i'm excited about this is you know ginkgo has worked out the hard challenges over the last 10 years uh of building out our own automation and software stack if you go to the next slide uh and and this is not just hardware it's also our code base our operations our data uh stack and everything else and we've done this over 200 R&D projects in agricultural, industrial, and pharma biotechnology. So we have the scars of knowing sort of what works and what doesn't work when you're doing this work at a high throughput. And if you go to the next slide, you know, our interest from customers is really around sort of large data set generation for AI. This has been wind in our sails as we've opened our platform up. Companies like Genentech and Recursion have been showing that you can use these AI models in service of drug discovery. That's meaning a lot more companies are interested in sort of automated data generation. And that's exactly what we've built the reps doing over the last 10 years. And so that's been an excellent conversation to have with customers. Now, you go to the next slide, you know, Ginkgo's technology is shown on the right here. That's our facility in Boston with our automated racks. You know, I will highlight the left-hand side of this chart, the lab bench with the Fisher catalog to order whatever reagents you need, is actually a very effective way to go do drug discovery, right? It's a very effective way to go discover plant traits and things like that. It allows scientists to order what they need when they need it. It's very quick. You get turnaround in 24 hours, massively customizable. There's nothing wrong with the left-hand side. It just is not great at generating low-cost data points. In other words, if you want to make a lot of data for an AI model or for high throughput screening or things like that, the bench is not your friend. You do need to move on to something like robotics. And I highlight that on the next slide as well. You know, these are just two different approaches that are quite complementary, right? It isn't like one has to replace the other. That's a lot of the conversations we have with customers. It's really that particularly as these AI models are gaining in prominence, you're going to want to have what we call a foundry, basically a generalized automated facility that can be quickly reprogrammed to make new large data sets to support your AI and ML teams alongside of the benches where your scientists are still doing small batch, very hypothesis-driven research. And by the way, what you learn over here from the Foundry and the AI models is going to inform those scientists' hypotheses. Absolutely. That's exactly what we've seen with the recursions in the Genentex of the world, where you can use the foundry for, say, target discovery, and then get in the lab at the bench and go test those targets out quickly by hand. So that type of feedback loop, I think every major pharma, every large research institute will ultimately need to have sort of a foundry type setup to complement their lab benches. All right. So Ginkgo Data Points is our first offering in this area. I'm not going to spend, I talked a lot about it the last earnings call. Just a quick update on this. We launched actually just yesterday well yeah monday uh our gdp a1 data set uh and these data drops are very valuable uh for the community uh and they showcase the output of our data point services so this is a really great one there's a there's a new uh preprint that came out you can see on the right there's a link at the bottom to go download the data set but you know 246 different therapeutic antibodies and you can see these 10 different developability assays listed on the left and And then importantly, all that data is in a really clean format for your AI or ML team to go play around with it. And so we're going to keep doing this. You'll see us keep putting out data sets. The data scientists love these. It creates new customer demand for us, and it showcases just what our platform can do. Okay, so I want to spend a chunk of time real quick talking about Gitco automation and some of the interests we've seen around, in particular, AI reasoning models and connecting those to automated platforms in the lab. First, I want to mention we had a big win. So we announced a week or two ago that we had partnered and sold a system to Ara Genetics. This is a diagnostics company building out a new facility. This is really exciting to me because, you know, on the next slide, you know, we've obviously had a lot of success with early customers like Octant in the drug discovery space. You know, 7x throughput increase, 88% reduction in hands-on time. They've been using the system for two years. they were kind of our original drug discovery beta customer a lot of conversations with high throughput screening pharma companies definitely going to buy this but diagnostics companies is really a new market for ginkgo uh so i'm really excited to see the automation going there and i think this is one of the exciting things about ginkgo's platform going out as tools okay when we're offering solutions we had sort of like a much more narrow window of where we could apply I say, our automation, right? It was ultimately going up through this kind of window of a research project associated with cell engineering. Now, the automation could really go anywhere to any lab that would benefit from integrated automation. And, you know, you can see that with our rack carts. If you go on the next slide, you know, the idea behind the get-go automation is we're basically creating a standardized physical wrapper around a piece of laboratory, you know, essentially benchtop hardware so that's that's a centrifuge there that orange thing inside the rack then we have a robotic arm and then we have a piece of magna motion track which is a kind of like a little railroad track that can move material along it and deliver a 96 or 384 or whatever well plate to that robotic arm the arm picks it up and puts it onto the in this case centrifuge all right and so what you've done is you've taken a piece of lab equipment that today is very custom right you know like it's coming from some particular vendor it's got its own software you got to walk up to it and interact with it and you put it inside this box and once you've done that if you go to the next slide you can stick that that rack cart together with as many other ones as you want in a line and let's say you had 10 pieces of equipment you wanted to integrate we would send you the 10 carts with that equipment you would stick them in a line and then you would use our cloud software to control it. And suddenly you don't need to be in the weeds in the software on all 10 pieces of lab equipment, because our software has parametrized control of all of them. And we didn't have to, like a traditional integrated automation vendor would basically do a big custom design for you, a custom engineering project that would take a year or something to ultimately design and build and get it shipped and installed for you. If we had these 10 racks available, we could send them over and put them together in a very short period of time. And so, you know, a matter of weeks. And so that is really exciting and a big change to how you build out integrated automation. The other big change, other than just speed to deploy, is it's expandable. So when you normally build a custom integrated setup for automation, it's built to do one thing, right? With these rack systems, for example, this is a system we have in Boston. We had five of these to start with, I think, or six doing NGS prep. That was like the original application. And then we were able to keep adding more racks. We now have 25 racks on this setup. And we have a whole range of different, you can see it here, equipment that have been integrated into these systems. We have three different sizes of racks so that we can integrate this equipment. This is out of date. We keep adding stuff. Whatever customers want in their setup, if there's a piece of equipment that we haven't yet integrated, we can get it integrated in a few weeks. And so really excited about this kind of general concept and customers are loving this as well. You can see our booth here at the SLAS show on the next slide, you know, and what I like about this, actually the top right corner, there was a, this is actually a JP Morgan recursion at a party and we said, Hey, can we bring the racks? And so we were able to set them up, you know, in a few hours in the afternoon before the cocktail party and have the moving plates around. So that's the kind of speed in terms of deploying an integrated automation setup that you just really don't see with other technology. This next slide is a picture of our facility in Boston. That's that, this is an older picture, but that's that 25 rack setup I was mentioning. And another thing that's unique about Ginkgo is that we actually run our own automation. This is our BSL-2 lab here in Boston to do high-throughput data generation for these research projects we're doing for customers. So we have a lot of experience understanding sort of bio-validation and moving these high-throughput protocols onto integrated automation. So one of the things I'm really excited, and we have customers reaching out to us about this system, if you go to the next slide, is this application of what people are calling lab-in-the-loop or sort of physical AI in the lab. And so just to give you an example of this, so if you were to go on to ChatGPT and click that little deep research button and you ask it a question, instead of getting an answer in five seconds, it's going to give you an answer in like five minutes. And the reason for that, and you can even ask it if you want to see it doing this, you can say, hey, show your thinking, and you'll see what's called chain of thought reasoning. And so what the model does is it says, okay, based on what you've asked me to do, I've broken this problem into pieces. And for piece number one, I'm going to go call up a web browser and do some research on the internet. And then based on that information I get back, there's a bunch of numeric data in there. So I'm going to write a Python script to analyze that data. And based on the results of the Python script, I'm going to do some more thinking and analysis and I'm going to write you a summary. And it goes and does all this. it's absolutely fabulous. You really should see it if you haven't. But what's gotten people excited is that type of reasoning and analysis. What if you were to then connect a reasoning model like that into the physical world? And so there's a lot of activity right now, a lot of startups getting funded to do like robotic hands to like pick things up and fold shirts or assemble electronics. But what I think is really exciting is could we give that reasoning model hands in the lab uh and that's how we see our racks they're actually like a perfect fit for this uh we're able to integrate you know i mean you could integrate 100 pieces of equipment um we have a one project where we're scoping that with racks uh but in boston for example we already have a setup with 25 pieces of lab equipment set up um and if you go to the next slide a reasoning model could go ask that that set of equipment to run some experiments and then get back really rich data time series data raw data files the racks give a whole bunch of event data limbs metadata um you know about exactly what's going on inside that experiment a lot more data than you would get if you were doing the the experiment by hand at the lab bench these are just things that you wouldn't be collecting um you just wouldn't be collecting them because you're doing a lot of small things as you work at the bench that aren't really being recorded uh but everything is being recorded when it's being run uh on automated setups and if you go to the next slide you can see, we've already demonstrated this is a 24-hour protocol without any human intervention, 10,000 qPCR reactions. These are the types of things we can do. This is just one example of sort of just a large data set on a complex protocol being run over a long period of time. So these sort of like long, continuous experiments, ideally with a reasoning model, controlling it and talking, you know, being able to having those hands in the lab is something we're really excited about. We a lot of customers excited about too uh and so uh if you go to the next slide i'll just say for customers tuning in again this is what's special about ginkgo compared to a traditional automation vendor over the last 10 years we have been building and running a highly automated lab and that's not just having the automation set up and doing one thing over and over again it's doing many things collecting the data off that automation getting it cleaned up and back to the scientists there's a whole software and data stack needed to really make the most out of these sort of automated data foundries uh and so if you're tasked to uh bring ai you know into your research department or deploy these sort of lab-in-the-loop models uh we're more than happy not just to engage with you on the automation but really on a consultative basis uh to help you build out your whole uh technology stack internally and we are uh we've actually started doing that for some large farmers now as well so so these are i think uh uh just some of the things i wanted to update on i think this whole push on the reasoning model and ai side is really exciting um and again i want to just highlight and thank the team for an enormous enormous amount of work over the last year for us to be in the position we are today where we have growing opportunities on the tool side we have world leading automation we have over half a billion dollars in the bank and our spending is under control uh is a far cry from where we were a year ago uh and so uh again kudos to the team for pulling that off and uh look forward to hearing your questions thank you so much.

Great. Thanks, Jason. As usual, I'll start with a question from the public and remind the analysts on the line that if they'd like to ask a question, please just raise your hand on Zoom and I'll call on you and open up your line. Thanks, everyone.

All right. Getting started. So our first question is from x.com. And this question is from That's Brendan. Excuse me. The question is, does Jason think there's a possible opportunity for data points to evolve into a SaaS cloud computing product tool to compete with traditional companies in the space like Viva Systems?

Yeah, it's actually a good question. So I mentioned this a little bit at the end, but we've been starting to do more of these like, well, at least kind of I'll call it consultative, almost like tech enabled consulting for a large pharma company where we're actually coming in and helping them think about their data architecture and like how you should, you know, you're going to run a big automated lab, what does it look like? What software do you need to have in place to do that? What kind of data systems you need to have in place to do that? And so forth. And I think this is something that Ginkgo has a lot of very uniquely specialized expertise in. There's a question of how to go to market with that. Do you actually want to go all the way to offering SaaS software? Do you want to just do consultative work and then be able to bring in things like our automation technology alongside that and so on? We're sort figuring that stuff out. But certainly companies do do make plenty of money in the sort of cloud and SaaS space. So if we saw an opening there, I would say the research side of the house is a little different when it comes to commercial, where I think you already have a lot of these tools and like pharma sales and things like that. But when it comes to the research side of the house, many, many companies are not don't already have in place large sort of data infrastructure. And so, again, most of the work is done at the bench, most of it is not large data sets, with the exception of things like high throughput screening. So as they build out more of that, I do think there's an opening. We'll have to see if if if it's a business for us. But I definitely it's a place we can help, I would say.

All right. Now for some questions from our analysts. The first question is from Michael Riskin from Bank of America. Michael, you are your line is open.

Great. Can you guys hear me?

Yeah.

Hey, Michael.

Hey, how are you? Thanks for taking the question. I wanted to ask kind of a two-parter, but on the same topic. One is on the ARPA-H news you provided, just sort of wondering if you could provide a little bit more details on some of the economics beyond that. You know, we have the headline number in terms of the $29 million contract, but just thoughts on, you know, how and when that will be recognized, how that contributes to revenues. And then related to that, you had a couple of slides where you talked about government contracts, government relationship, things like that. Just wondering what the latest on those is, given the current environment with Doge, cutting back a lot of that funding. Have they been reviewed already? How safe are those? And if you could talk about any take or pay considerations there, that'd be helpful.

So Jason, I'd be happy to take the first part of that. So the ARPA-H, just in terms of kind of economics, how the revenue flows. So it's a $29 million two-year contract. So you can sort of expect sort of generally revenue to be recognized over two years. And then I guess the second point I would just make is that from our perspective, that really significantly de-risks the guide for the year. and so um uh yeah so so i i i think it was um very good news to be getting that from the perspective of this year yeah that to sort of speak to the second part yeah that was one of the ones we were keeping an eye on that we had sort of gotten awarded uh knew we were going to get it but we hadn't closed on contracting um so i do think in general um like i mentioned i i think biotechnology technology is still on the short list of critical emerging technology.

So I'm generally hopeful that any additional programs that we have that aren't quite contracted yet will move through. But importantly, that they'll still continue to be funding, like Mark said, that we was sort of the big bogey on that for us for this year. But in general, what's more important is like, do we keep seeing the funding of advanced research in this area? We think so. And then certainly on the biosecurity side, you know, there was a couple of executive orders just today related to bio. I don't know if you saw that, but there was one on regulatory relief to promote domestic production of critical medicines. So that's right in line with sort of the wheat project and generally on shoring. It's basically reducing regulation for people building out manufacturing for pharma. Not something we do, but just to speak to this being a critical priority. And then second was improving safety and security of biological research. This is around like not funding data function work, but again, speaks to, I'd say, biosecurity being on the list of things that are not being written off is not important. So, you know, cautiously optimistic, but of course, you never know.

If I could squeeze it just to follow up, Mark, on the first point on the ARPA age, just clarify, there's multiple partners in that, right? So is there any clarity ahead of time how that $29 million gets split up or?

Yeah, so we're the prime, which means we will recognize all the revenue on that. And you would then see sort of in the cost of sales or in the R&D expense line, the effect of the subcontractor costs on that. But we would be recognizing the full amount of revenue. Okay. All right. Thanks.

All right. Our next question is from Mark Massaro, who's from BTIG. Mark, you're live. Mark, you're muted.

All right. Maybe we can...

No, we got you, Mark. Okay, cool.

All right.

Sorry. You got me now?

Awesome. Thank you for the question. So I wanted to just ask a question about the revenue generating program metric. Maybe this could be for you, Mark. Just help us think about how we should be tracking the economics per program. So if I'm doing the math right, it looks like the revenue per program might be down in the quarter. Can you just give us a sense for how we should think about that? Is that something that should grow? Or is it because you're onboarding newer programs that are just starting to generate revenue, it takes some time to move up?

It's actually a little bit of a mixed shift from sort of the new data points. So the number of data points, you may see some, but it's still too early days to kind of predict.

Okay. And then the other one is just, and I recognize the new reporting structures is early days. But if I have this right, it looks like your revenue generating programs increased by 21. Do you think about that progressing throughout the year? And then I would just be curious if you could just give us any color as to sort of like the flavor of some of these programs and what might have surprised you in the quarter.

So it's so you're going to have programs that complete and programs that onboard. And so the kind of net impact of that means you probably are not going to see a net plus 20 sort of quarter after quarter after quarter after quarter. You're going to have some quarters where we finish a bunch of programs. And so, again, still early days, Mark, with the metric. But I think we're all sort of keeping our eye on that trend line. The flavor in terms of what's in there. So there's still, I would say, like generally speaking, the solutions deals, of course, are bigger. The data points deals are smaller. There are just a few automation deals in the mix right now because that's really the newest of the tools offerings. We did sign a bunch of ag solutions deals in Q1, which is new. I think it might have been the most new programs that I remember in that sort of part of the business in a single quarter. Or that said, they're all relatively small in size. And so you can think of those as almost pilot in terms of scale relative to the solution side of the business. So, yeah, I would just say probably, like, the flavor is good diversity in terms of what we're seeing with big programs, small programs across ag, biopharma, et cetera, data points, solutions.

Great. Thank you.

Thanks, Mark. All right. Next question from Tejas, who's coming from Morgan Stanley. Your line is open.

Hey, guys. Good evening. And thanks for the time here. So maybe, you know, a sort of predictable question for you, Jason, just on the continued pressure on pharma and biotech here, you know, the commentary from service providers, you know, through the starting season has gotten incrementally more cautious i guess yeah yeah and i guess um you know a lot of sort of nebulous concerns out there you know things like tariffs and reference pricing this afternoon we heard of you know the appointment of a new head of seabird today um pretty vocal stands and accelerated approvals and surrogate endpoints and whatnot so um i'm just curious as to you know what you're hearing from your customers, especially over, you know, the last like six to eight weeks when things seem to have sort of ratcheted up a little bit, if you will?

Yeah, I mean, I would say overall, it is like there is a lot of sort of hesitancy in general around R&D services. So like, I think you're just seeing a less outsourcing of stuff, people are like more protective of their internal teams. So that's like, that headwinds for us on the solution side. I think if you look across the industry broadly, there's less demand going to like basically all CRO and equipment and tools vendors. I think that's, and you've seen that reflected in the pressure on all of them. I've mentioned this before, Ginkgo's new in the tools industry. So unlike, say, Awushi or somebody that's like highly penetrated across the whole industry and sort of moves with the total demand, we're more winning pie, you know, from others. And so I think there's a lot of opportunity for us still uniquely in tools, but I would say the whole sector is definitely under pressure. You know, I think that probably means places invest less in new advanced technologies, you know, right? Like I think you're less likely to see a lot of the current players like doing some big project to expand in a new area right now. so that's maybe good for us because we're sort of an innovative new entrant. But I would say across the industry, I'm hearing from people what you're hearing, which is pullback on things. But I don't know that Ginkgo maybe gets affected a little less on that when it comes to our tools business. I do think on solutions, it makes it tougher for us. Got it.

That's helpful. A couple of quick cleanups for Mark. Mark, can you just share some colors, just ballpark numbers to help us bridge from you know your old program ad metric the new uh revenue generating programs um and then uh you know i think on the last call you guys had talked about you know a little bit of potential upside from um the tools offering and a number of pharma deals that closed in the fourth quarter so just curious as to you know how those those opportunities have evolved since um and then you know on this sort of pharma reshoring point jason which you alluded to a little bit earlier um is there an opportunity beyond sort of the work you're doing with r by h here in your mind for ginkgo to participate in all right so why don't i start

there so in terms of bridging the old metric to the new so the new metric um very importantly excludes programs with de minimis revenue in the quarter so that would typically be a program that is either just starting or is in the final stages of completion and we really in any particular quarter in the past had quite a lot of those like like we might have had you know just like rough numbers 20 to 30 programs that were in kind of a start mode and a maybe similar number that were in a final stage of completion mode and so those would be kind of out of the mix right now completely however it's not a straight subtract because we're now including programs that wouldn't have been included in the past because they didn't meet the sort of definition of what we thought of as a major program. And so a lot of the sort of smaller data points programs or even small solutions programs wouldn't necessarily have been included in the past at all under the definition. And so those are now kind of in the mix. So that's sort of like the rough bridge here. Now, if you look in the appendix to the presentation, we have included a restatement of, or I would just say the historical comparables that you need on the current metric so that you can see what it was in each quarter of last year. So that'll help you kind of bridge the old to the new. On your second question, upside on tools and pharma. So I think probably the best way to put it is in terms of the revenue guide, yes, the guide is still being, I would say, relatively conservative in terms of what we're expecting from tools this year so so still kind of in that you know low double digit million dollar contribution on a full year basis and and just to put that in context in the first quarter tools contributed sort of low single digit millions in terms of revenue so less than 10 percent of the cell engineering revenue in q1 came from the tools offering and then we would expect that number to increase uh as we get sort of through the year but um it's still early days so we're being conservative there but i would say there's there's upside potential on the tools side of the business uh particularly on data points i think what we're learning on automation is that is a longer cell cycle uh with respect to some of the bigger like the by your point on biopharma uh yes i mean i think we're happy with how we're executing on those deals right now, and I think we'll be looking to see whether or not we can kind of expand the relationships with some of those biopharma as we execute on some of the first projects that we have with them in data points.

Yeah, I would say I think one of the things with the biopharma is we can get in with a proof of concept. We're adding and continue to add new logos there, which is always exciting for Ginkgo because we have a variety of things we can sell to people. And so getting in and proving ourselves and getting set up with the procurement system at these places is all just like wins for us. So that continues to work, like the proof of concept deals. The hope is that those then grow into larger programs and data points or maybe an automation purchase. And then when it comes to the onshoring that you asked about to us, I think one application there for us would be using the automation for some of the QC on. And so there's usually a variety of different assays that are being included in the quality control for therapeutics coming off the manufacturing. Those are often like can be pretty complicated experiments and can be a good fit depending on the drug for some of our automation. So that's one place I think we could play. We obviously don't do, we're not a manufacturer, so you won't see us like building a new site. We're not like Alonza or something, but I do think on the automation side, we could Got it.

Super helpful. appreciate the time yep all right uh next up we have matt sykes from goldman sachs matt your line is open hi this is ev on for matt thank you for taking my questions uh so the first one great to see the deal with aura uh how do you view the longer term opportunity within the diagnostics for racks and then are you seeing any interest from customers in this space on the on a broader scale especially given the durability of that end market versus earlier stage r d spending Yeah, we think it's a great, great fit for diagnostics.

I mean, what makes the racks unique compared to like a traditional integrated setup is that it is expandable. So, you know, when you're getting a work cell set up to do, you know, whatever your particular diagnostic reaction, like you're trying to predict how much demand you have, that work cell has a certain capacity. If you start to exceed that, the current industry standard is basically build a whole another work cell. Whereas with the racks, you could take whatever piece of equipment it is that your current bottleneck on your diagnostic process and just add a second one to the setup and potentially alleviate that bottleneck. So that's real exciting. It's also like not something that sunsets in the event that your mix of diagnostic demand changes in the future, right? So what's great about the racks is some of the equipment is likely to be common across different protocols you're running. And you could, if you had, say, a new protocol you brought online, let's say you wanted to add some sort of like NGS diagnostic to your current setup, you know, you could then add a few pieces of equipment to the very same rack setup you had running your first protocol and add a second one. So this is a, you know, I mean, like, we're obviously biased, but like, we really think of it like you're building an automation core that can be used for lots of different things rather than a work cell that's meant to do one thing. And that's really compelling. It totally changes the ROI calculation for people building out integrated automation. So we think we should be on the RFP and the look for anybody building a new automation facility. We got to get the word out in the market, but it's really exciting to me to see us getting this first diagnostics deal like that. We really see ourselves able to play in that space.

Okay, great. And then on the EBITDA breakeven target for the end of 2026, have you uncovered any areas of upside as you work through the cost cutting exercises? And then on the flip side, how are you able to balance the spending to make sure that the new offerings get good initial traction commercially while also meeting the profitability goals?

So Jason, I'd be happy to take the first part and maybe hand the second part over to you. So we do still have room to go on cost. And that's why we upped the target to 250 million. I would say, Evie, yeah, there's probably still some room after we get to that level. We largely at this point have taken the actions that we need to take in order to get to the 250. There's still a little bit of work to do there. So you'll start to see the impact of that part of the cost reduction roll through the kind of Q2, Q3 numbers. But we are, I think, sort of being careful at this point that, and I'll let Jason just talk about the kind of new opportunities. I wouldn't say though, Evie, there's some like very large, you know, sort of silver bullet kind of upside cost reduction opportunity, other than, of course, subleasing the excess space, which we all know is a challenge in this market. Other than that, we're much more into the weeds. I'm looking at sort of small dollar kind of line items. And that's sort of where we're at right now. There aren't like these big chunks of upside anymore.

Yeah. And just a comment on the tool side. I mean, you won't see us do anything pathological, if that's the question, right? Like, so the, you know, if we see opportunity where, you know, by investing in, you know, for example, just, you know, today we put out another sort of data drop from data points for cell paintings. This is like a imaging based data set. So you can have bright field, you can do the cell painting. These are becoming like common high content data sources for people doing like a IML for drug discovery, right? Like that's that's the first time we put out a data set like that. we love to do stuff like that. We already have a ton of interest in that, a lot of people downloading it. You'll see us keep doing that, investing in new areas for data points. No brainer. As long as when we put out a new one, we see new customers, you won't see me stop investing in that sort of thing. Same with like on the automation side, we see opportunities to demonstrate particular workflows and show people. We put out these sort of like white papers and demonstrations of what you can do on the racks. I see a lot of upside in all those things. You won't see us slow down there just to meet an EBIT to target. But all things equal, we do see a good line of sight to getting to it by the end of 26. So it is a focus. But a lot of it is really just tightening up on the solution side so that we have room to invest in tools. That's really the big motion.

Great. Thank you so much.

Yeah. Thank you. I think we have one last question. I saw another pop up, but I think we probably just have time for one more from Matt LaRue, who's coming to us from William Blair. Hey, Matt.

Hey, good afternoon. Thanks for taking the question. Jason, if I think back to 23, 24, when there were perhaps different, but in some way, similar macro constraints with respect to biotech funding, you really were selling- You'd like it to end sometime. Well, we had three weeks of positivity at the beginning of this year. um the you know you were really selling one or at least just a couple of solutions the the contract structure was perhaps more onerous to get deals done in terms of longer lead times um and there was maybe more of a focus on biopharma um though I know that remains today if I then fast forward to today and maybe we're entering you know more macro uncertainty from a variety of different angles you now have a number of different product offerings that span content tools automation etc et cetera, you've opened up the way you're thinking about doing deals and different sizes and structures. But you also alluded to in your earlier comments, this sort of inherent push-pull between the willingness to outsource. Does the same dollar amount mean that less work gets done or does it push people to do more work, to work more efficiently, right? So some of these tensions. So I'd just be curious, either in the first couple of months of the year or what you're seeing and hearing from customers, how you think Gitco can fit into if this macro situation deteriorates or remains uncertain, how you fit into the picture differently this time than perhaps, you know, a couple of years ago.

Yeah, I mean, I think the biggest thing is with the tools offering, like you can, you can like take smaller bites and engage with us, right? Like the, what I would have had 2324 was there was the really only way to deal with Ginkgo was these sort of big R&D projects. um that type of big outsourced r&d work across the industry like you know pick your favorite small biotech in cambridge it's not getting like a large research partnership right now with like major pharmas or mid-sized pharmas so that that that's just that's just the reality right so i think the thing we've done well in the last year and again i think this continues to speak to a the flexibility of the platform we built at ginkgo where really like the core heart of it is is sort of a lot of this automation and software infrastructure and approaching a biolab like a factory, that's proving like very durable to be able to take in different directions, all the way from industrial biotech, you know, when we first would have been talking to you through ag to pharma to now different styles, whether you're selling it as solutions and tools. You know, I think like, you know, we're tough to kill, right? I think that's sort of what's been proven over the last couple of years here at Ginkgo. And so I think that speaks to the strength of the platform. I would, I do think there is some, you know, looking for silver linings, like whenever there's churn, you know, right, like right now, like, for example, with the FDA, you're seeing a lot of interest around changing how we approach, you know, things like toxicology with, you know, with the government in general, a lot of issues around how we're approaching other countries, particularly China doing our work. I mean, look, if Wuxi gets nuked, that's like, that's a huge opening for us, right? If it's like, hey, you can't use them, then there's a lot of new CRO business to be had, right? So there are things there that could change the macro for Ginkgo specifically, we'll see, right? But I think what we've shown is Ginkgo's resilient, Ginkgo will change as the market changes around us, and we're not going to die, right? So that I think remains the case 23 to now. But certainly, I'd say the biggest change is us going to market with tools, which is much more favorable for this current environment in terms of what customers are up for buying. Smaller chunks, more arm's length is what the market demands right now.

Got it. And then maybe as a follow-up to that, Sirius, the lead generation and closes for the newer programs, data points, the tools offerings, are most of those internal in the sense that perhaps you were actively engaging with the customer would be on a broader, different project, and then that didn't work, but hey, you know, something else popped up you can do, or are most of those external at this point as people get more awareness about them?

It's a lot more stuff coming externally now. That's great about the tools business. Like we put these data drops up, like the one we did today, and people just download it and give us emails. We follow up and we've gotten, you know, chunks of business that way. It's pretty neat. um so so that's exciting within our close accounts we certainly are able to uh expand right so like you know there's our fees out right now for automation systems with customers that we've had multi-year engagements with um on the solution side that's obviously puts us in a really nice spot so so we do see some of that but it's not the only uh source of leads we are again with the tools business and ideally i'd actually like the tools business to keep enabling smaller and smaller bite-sized chunks right so you so you know watch us over the course of the year hopefully be able to launch uh other things that let people bite off even smaller bits because i just think that's that's what's still selling um and so um but yeah but it it is definitely we're also getting

external inbound now which is nice all right great thanks for the updates yep well unfortunately i think we're out of time hey daniel i think i see brendan with a with his hand up oh sure yeah so i we can fit in one more for sure sure go ahead brennan awesome thanks guys can you hear me okay yeah yeah awesome thanks for squeezing me in um mark i don't know how you really do that that's amazing that's beyond my my zoom skills so yeah brennan appreciate the question go ahead always happy to impress um yeah so maybe just quickly kind of kind of expounding on a couple to questions previously um really on the ai tools offerings um can you speak maybe just a little bit more on kind of the training data you're using for some of these models and and really just where you're sourcing some of that from just we're starting to get questions on where you know as there are more offerings kind of across the sector where people are kind of sourcing a lot of this stuff from are you able to use partner or licensee data sets to train back train your models or is everything kind of proprietary and generated in-house um really more so understand trying understand how scalable some of those could be over the longer term for you guys yeah i can speak to that um so yeah we've done a few experiments with this so just so you know like the um the models we've put out like a zero for example which is like an esm style model trained on our uh both the public data plus our internal you know remember we acquired like warp

drive bio and radiant genomics imergen there you know ag bio there's all these like uh genomic assets we've kind of piled up over time that are actually larger than the public data set, I believe at this point, or at least comparable. We trained it up on that. So that is proprietary data. I will say, I think that market's early, right? We're not... The ability to go to market as just a pure model company right now in the way that the tech companies have been able to do on the language side, I don't think is really bearing out in the market yet. So that's served as kind of a uh like an appetizer to help people come in for data points uh to like generate their proprietary data at the large mid-sized pharmas um but like just going to market as a like purely as a model i don't really see it working in the market today uh certainly people are trying it we tried it um but it hasn't been a big revenue driver for us yet unfortunately okay all right gotcha thanks guys appreciate the time yep thanks brennan um all right i think that's uh that's all for tonight.

Just a reminder, if you have any other questions, you can always email us at investors at gankobuoworks.com. Thanks for joining us.

Yep. Appreciate all the questions, everybody. Thank you. Thank you. Bye.