JAZZ · Jazz Pharmaceuticals plc · Insider Trading

The sales of ordinary shares reported on this Form 4 were effected pursuant to a broker-assisted sell-to-cover exercise of fully vested stock options scheduled to expire on March 1, 2027. The ordinary shares were sold solely to cover the aggregate exercise price and applicable tax withholding obligations. The Reporting Person retained all remaining ordinary shares acquired upon exercise.

Reflects sales of ordinary shares executed in multiple transactions at prices ranging from $236.2900 to $237.2600. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

Exercise of stock options before their expiration date.

These options are granted pursuant to the Issuer's 2011 Equity Incentive Plan. The ordinary shares subject to these options vest over four years measured from the grant date, March 2, 2017, with 1/4th vesting on the first anniversary of the grant date and the remainder vesting in 36 equal monthly installments thereafter.

The sales of ordinary shares reported on this Form 4 were effected pursuant to a broker-assisted sell-to-cover exercise of fully vested stock options scheduled to expire on March 1, 2027. The ordinary shares were sold solely to cover the aggregate exercise price and applicable tax withholding obligations. The Reporting Person retained all remaining ordinary shares acquired upon exercise.

Reflects sales of ordinary shares executed in multiple transactions at prices ranging from $237.2900 to $237.7600. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

Exercise of stock options before their expiration date.

These options are granted pursuant to the Issuer's 2011 Equity Incentive Plan. The ordinary shares subject to these options vest over four years measured from the grant date, March 2, 2017, with 1/4th vesting on the first anniversary of the grant date and the remainder vesting in 36 equal monthly installments thereafter.

The sales of ordinary shares reported on this Form 4 were effected pursuant to a broker-assisted sell-to-cover exercise of fully vested stock options scheduled to expire on March 1, 2027. The ordinary shares were sold solely to cover the aggregate exercise price and applicable tax withholding obligations. The Reporting Person retained all remaining ordinary shares acquired upon exercise.

Reflects sales of ordinary shares executed in multiple transactions at prices ranging from $235.2700 to $236.2400. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

The sales of ordinary shares reported on this Form 4 were effected pursuant to a broker-assisted sell-to-cover exercise of fully vested stock options scheduled to expire on March 1, 2027. The ordinary shares were sold solely to cover the aggregate exercise price and applicable tax withholding obligations. The Reporting Person retained all remaining ordinary shares acquired upon exercise.

Reflects sales of ordinary shares executed in multiple transactions at prices ranging from $234.2650 to $235.2350. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

The Reporting Person acquired 163 ordinary shares under a Section 423 Employee Stock Purchase Plan on May 29, 2026.

These options are granted pursuant to the Issuer's 2011 Equity Incentive Plan. The ordinary shares subject to these options vest over four years measured from the grant date, February 28, 2019, with 1/4th vesting on the first anniversary of the grant date and the remainder vesting in 36 equal monthly installments thereafter.

This transaction was made pursuant to a plan adopted by the reporting person on June 4, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

This transaction was made pursuant to a plan adopted by the reporting person on November 26, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

This transaction was made pursuant to a plan adopted by the reporting person on June 4, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

This transaction was made pursuant to a plan adopted by the reporting person on November 26, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

This transaction was made pursuant to a plan adopted by the reporting person on February 26, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

This transaction was made pursuant to a plan adopted by the reporting person on June 4, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

Shares withheld to satisfy tax obligations arising out of vesting of a portion of previously granted restricted stock units.

Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

This transaction was made pursuant to a plan adopted by the reporting person on November 26, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Includes the November 3, 2025 disposition of 3,193 shares for the withholding of restricted stock units by the Issuer to satisfy FICA taxes arising from the Reporting Person being retirement eligible which was previously inadvertently not reported; not an open market transaction.

Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

This transaction was made pursuant to a plan adopted by the reporting person on May 28, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

These options are granted pursuant to the Issuer's 2011 Equity Incentive Plan. The ordinary shares subject to these options vest over four years measured from the vesting commencement date of May 29, 2019, with 1/4th vesting on the first anniversary of the vesting commencement date and the remainder vesting in 36 equal monthly installments thereafter.

This transaction was made pursuant to a plan adopted by the reporting person on May 28, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

This transaction was made pursuant to a plan adopted by the reporting person on May 28, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

Reflects sales of ordinary shares executed in multiple transactions at prices ranging from $247.29 to $248.24. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

This transaction was made pursuant to a plan adopted by the reporting person on May 28, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

These options are granted pursuant to the Issuer's 2011 Equity Incentive Plan. The ordinary shares subject to these options vest over four years measured from the grant date, February 27, 2020, with 1/4th vesting on the first anniversary of the grant date and the remainder vesting in 36 equal monthly installments thereafter.

This transaction was made pursuant to a plan adopted by the reporting person on May 28, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

These options are granted pursuant to the Issuer's 2011 Equity Incentive Plan. The ordinary shares subject to these options vest over four years measured from the grant date, February 27, 2020, with 1/4th vesting on the first anniversary of the grant date and the remainder vesting in 36 equal monthly installments thereafter.

This transaction was made pursuant to a plan adopted by the reporting person on May 28, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.