Executive readout · one minute
What the filings say
- 8-K earnings release · filed Nov 10, 2026
- Sionna plans to initiate the AscenSION CF Phase 2 proof-of-concept trial of SION-451 + SION-2222 in the first quarter of 2027; $249.8 million in cash is expected to fund operations into the second half of 2029.
- 10-Q report · filed Nov 10, 2026
- Sionna Therapeutics selected SION-451 + SION-2222 for the AscenSION CF Phase 2 trial, expected to begin in the first quarter of 2027. SION-719 missed its key endpoint, prompting an approximately 46% workforce reduction; cash of $249.8 million supports operations into the second half of 2029.
The audio replay and transcript follow the call.