Frazier Life Sciences Management, L.P.
Filing Date
Global Rank
#633
/ 8,232
▲ 79
Top Industry
Biotechnology
98.1%
3Y Alpha vs SPY
+10.8%
Period ended 2 months ago
Filed May 15, 2026 · 29d
17 quarters · since Mar 2022
Clone Performance
Jun 2023–Jun 2026 · vs SPYHypothetical growth of cloning every reported 13F position and rebalancing on each filing, indexed to the same start.
Cloned portfolio
+129.8%
SPY
+76.5%
Annualised alpha
+11.1%
Max drawdown
−36.1%
Estimate. 13F holdings are quarter-lagged and long-only, so the clone rebalances about 45 days after each period end — when the filing becomes public — and excludes options and short positions. Past performance does not predict future results.
Portfolio Concentration
36 positions · as of Mar 31, 2026 · Δ vs Dec 31, 2025Top Position
18.3%
+2.1 pts
Top 5
55.2%
+3.3 pts
Top 10
73.7%
+1.4 pts
HHI
829
Diversified+71
Portfolio Trend
17 quarters · across all stocks
Sector Breakdown
As of Mar 31, 2026| Sector | % Portfolio | Value |
|---|---|---|
| Healthcare | 100.0% | $3,872,946,698 |
Last Quarter's Activity
Export CSVAdded To
Positions the filer increased
8 positions
| Ticker | Company | Δ Shares | Shares | Value | Open |
|---|---|---|---|---|---|
| ERAS | Erasca, Inc. | +1,945,752 | 24,675,188 | $399,244,541 | |
| MNKD | Mannkind Corp | +1,675,000 | 5,900,000 | $14,455,000 | |
| MIRM | Mirum Pharmaceuticals, Inc. | +884,563 | 7,679,684 | $709,449,207 | |
| CYTK | Cytokinetics Inc | +225,237 | 1,159,879 | $76,447,624 | |
| PVLA | Palvella Therapeutics, Inc. | +160,000 | 882,400 | $109,991,160 | |
| ACAD | Acadia Pharmaceuticals Inc | +141,000 | 1,438,198 | $32,014,287 | |
| IMCR | Immunocore Holdings plc | +100,000 | 484,782 | $14,616,177 | |
| IRON | Disc Medicine, Inc. | +94,852 | 1,354,852 | $86,629,236 | |
| No positions match the current search. | |||||
Trimmed
Positions the filer reduced
9 positions
| Ticker | Company | Δ Shares | Shares | Value | Open |
|---|---|---|---|---|---|
| TRVI | Trevi Therapeutics, Inc. | −319,862 | 9,939,547 | $118,578,795 | |
| AUTL | Autolus Therapeutics plc | −175,414 | 4,447,910 | $6,138,115 | |
| SVRA | Savara Inc | −141,449 | 9,720,852 | $53,075,851 | |
| RVMD | Revolution Medicines, Inc. | −121,769 | 675,686 | $65,710,463 | |
| BBIO | BridgeBio Pharma, Inc. | −97,418 | 3,448,139 | $256,058,802 | |
| KALV | KalVista Pharmaceuticals, Inc. | −78,759 | 4,961,108 | $99,867,104 | |
| ALLO | Allogene Therapeutics, Inc. | −72,082 | 3,796,668 | $9,263,869 | |
| AGIO | Agios Pharmaceuticals, Inc. | −23,674 | 1,256,080 | $42,493,186 | |
| KRYS | Krystal Biotech, Inc. | −7,153 | 481,307 | $124,331,224 | |
| No positions match the current search. | |||||
New Positions
Positions the filer opened this quarter
3 positions
Sold Out
Positions the filer fully exited
4 positions
36 positions ·
$3,872,946,698 total
· as of Mar 31, 2026
| Ticker | Company | Type | Shares | Value (USD) | % of Portfolio | History |
|---|---|---|---|---|---|---|
| IBIO |
iBio, Inc.
Healthcare
|
Held | 1,953,467 | $3,711,587 | 0.10% | |
| AUTL |
Autolus Therapeutics plc
Healthcare
|
Reduced | 4,447,910 | $6,138,115 | 0.16% | |
| ALLO |
Allogene Therapeutics, Inc.
Healthcare
|
Reduced | 3,796,668 | $9,263,869 | 0.24% | |
| EOLS |
Evolus, Inc.
Healthcare
|
Held | 2,630,665 | $10,812,033 | 0.28% | |
| VALN |
Valneva SE
Healthcare
|
Held | 2,291,666 | $14,322,912 | 0.37% | |
| MNKD |
Mannkind Corp
Healthcare
|
Added | 5,900,000 | $14,455,000 | 0.37% | |
| IMCR |
Immunocore Holdings plc
Healthcare
|
Added | 484,782 | $14,616,177 | 0.38% | |
| GLUE |
Monte Rosa Therapeutics, Inc.
Healthcare
|
NEW | 1,000,000 | $16,450,000 | 0.42% | |
| ACRS |
Aclaris Therapeutics, Inc.
Healthcare
|
NEW | 4,925,374 | $18,470,152 | 0.48% | |
| ALKS |
Alkermes plc.
Healthcare
|
Held | 700,647 | $24,774,877 | 0.64% | |
| LXEO |
Lexeo Therapeutics, Inc.
Healthcare
|
Held | 4,424,725 | $25,397,921 | 0.66% | |
| ASND |
Ascendis Pharma A/S
Healthcare
|
Held | 133,333 | $30,497,257 | 0.79% | |
| ACAD |
Acadia Pharmaceuticals Inc
Healthcare
|
Added | 1,438,198 | $32,014,287 | 0.83% | |
| AURA |
Aura Biosciences, Inc.
Healthcare
|
Held | 5,100,000 | $34,119,000 | 0.88% | |
| ZLAB |
Zai Lab Ltd
Healthcare
|
Held | 1,902,320 | $35,782,639 | 0.92% | |
| BCRX |
Biocryst Pharmaceuticals Inc
Healthcare
|
NEW | 4,009,240 | $38,167,964 | 0.99% | |
| AGIO |
Agios Pharmaceuticals, Inc.
Healthcare
|
Reduced | 1,256,080 | $42,493,186 | 1.10% | |
| VOR |
Vor Biopharma Inc.
Healthcare
|
Held | 2,543,939 | $45,383,871 | 1.17% | |
| TARS |
Tarsus Pharmaceuticals, Inc.
Healthcare
|
Held | 728,644 | $51,114,376 | 1.32% | |
| SVRA |
Savara Inc
Healthcare
|
Reduced | 9,720,852 | $53,075,851 | 1.37% | |
| DYN |
Dyne Therapeutics, Inc.
Healthcare
|
Held | 3,153,082 | $57,165,376 | 1.48% | |
| RVMD |
Revolution Medicines, Inc.
Healthcare
|
Reduced | 675,686 | $65,710,463 | 1.70% | |
| CYTK |
Cytokinetics Inc
Healthcare
|
Added | 1,159,879 | $76,447,624 | 1.97% | |
| IRON |
Disc Medicine, Inc.
Healthcare
|
Added | 1,354,852 | $86,629,236 | 2.24% | |
| KALV |
KalVista Pharmaceuticals, Inc.
Healthcare
|
Reduced | 4,961,108 | $99,867,104 | 2.58% | |
| PVLA |
Palvella Therapeutics, Inc.
Healthcare
|
Added | 882,400 | $109,991,160 | 2.84% | |
| TRVI |
Trevi Therapeutics, Inc.
Healthcare
|
Reduced | 9,939,547 | $118,578,795 | 3.06% | |
| KRYS |
Krystal Biotech, Inc.
Healthcare
|
Reduced | 481,307 | $124,331,224 | 3.21% | |
| MAZE |
Maze Therapeutics, Inc.
Healthcare
|
Held | 4,567,274 | $136,333,128 | 3.52% | |
| PHAT |
Phathom Pharmaceuticals, Inc.
Healthcare
|
Held | 12,466,489 | $138,502,692 | 3.58% | |
| MBX |
MBX Biosciences, Inc.
Healthcare
|
Held | 6,652,013 | $198,562,588 | 5.13% | |
| ARQT |
Arcutis Biotherapeutics, Inc.
Healthcare
|
Held | 9,874,511 | $232,643,479 | 6.01% | |
| BBIO |
BridgeBio Pharma, Inc.
Healthcare
|
Reduced | 3,448,139 | $256,058,802 | 6.61% | |
| ERAS |
Erasca, Inc.
Healthcare
|
Added | 24,675,188 | $399,244,541 | 10.31% | |
| NAMS |
NewAmsterdam Pharma Co N.V.
Healthcare
|
Held | 16,943,774 | $542,370,205 | 14.00% | |
| MIRM |
Mirum Pharmaceuticals, Inc.
Healthcare
|
Added | 7,679,684 | $709,449,207 | 18.32% |