Frazier Life Sciences Management, L.P.
Filing Date
Global Rank
#801
/ 8,622
▲ 39
· as of Mar 2026
Top Industry
Biotechnology
98.1%
3Y Alpha vs SPY
+21.6%
Period ended 4 months ago
Filed May 15, 2026 · 3mo
17 quarters · since Mar 2022
Clone Performance
Jul 2023–Jul 2026 · vs SPYHypothetical growth of buying every stock this filer reported holding, rebalancing on each filing and indexed to the same start. Option positions cannot be bought this way and are left out.
Cloned portfolio
+175.6%
SPY
+67.9%
Annualised alpha
+21.4%
Max drawdown
−36.1%
Estimate. 13F holdings are quarter-lagged, so the clone rebalances about 45 days after each period end — when the filing becomes public — and it excludes option and short positions. It tracks 100% of reported value on average across 13 quarters. Past performance does not predict future results.
Portfolio Concentration
37 tracked positions · as of Mar 31, 2026 · Δ vs Dec 31, 2025Top Position
18.3%
+1.8 pts
Top 5
55.2%
+2.6 pts
Top 10
73.7%
+0.4 pts
HHI
828
Diversified+51
Portfolio Trend
17 quarters · across all stocks
Sector Breakdown
As of Mar 31, 2026| Sector | % Portfolio | Value |
|---|---|---|
| Healthcare | 100.0% | $3,876,499,965 |
Last Quarter's Activity
Export CSVAdded To
Positions the filer increased
8 positions
| Ticker | Company | Δ Shares | Shares | Value | Open |
|---|---|---|---|---|---|
| ERAS | Erasca, Inc. | +1,945,752 | 24,675,188 | $399,244,541 | |
| MNKD | Mannkind Corp | +1,675,000 | 5,900,000 | $14,455,000 | |
| MIRM | Mirum Pharmaceuticals, Inc. | +884,563 | 7,679,684 | $709,449,207 | |
| CYTK | Cytokinetics Inc | +225,237 | 1,159,879 | $76,447,624 | |
| PVLA | Palvella Therapeutics, Inc. | +160,000 | 882,400 | $109,991,160 | |
| ACAD | Acadia Pharmaceuticals Inc | +141,000 | 1,438,198 | $32,014,287 | |
| IMCR | Immunocore Holdings plc | +100,000 | 484,782 | $14,616,177 | |
| IRON | Disc Medicine, Inc. | +94,852 | 1,354,852 | $86,629,236 | |
| No positions match the current search. | |||||
Trimmed
Positions the filer reduced
10 positions
| Ticker | Company | Δ Shares | Shares | Value | Open |
|---|---|---|---|---|---|
| XLO | Xilio Therapeutics, Inc. | −5,492,586 | 422,505 | $3,553,267 | |
| TRVI | Trevi Therapeutics, Inc. | −319,862 | 9,939,547 | $118,578,795 | |
| AUTL | Autolus Therapeutics plc | −175,414 | 4,447,910 | $6,138,115 | |
| SVRA | Savara Inc | −141,449 | 9,720,852 | $53,075,851 | |
| RVMD | Revolution Medicines, Inc. | −121,769 | 675,686 | $65,710,463 | |
| BBIO | BridgeBio Pharma, Inc. | −97,418 | 3,448,139 | $256,058,802 | |
| KALV | KalVista Pharmaceuticals, Inc. | −78,759 | 4,961,108 | $99,867,104 | |
| ALLO | Allogene Therapeutics, Inc. | −72,082 | 3,796,668 | $9,263,869 | |
| AGIO | Agios Pharmaceuticals, Inc. | −23,674 | 1,256,080 | $42,493,186 | |
| KRYS | Krystal Biotech, Inc. | −7,153 | 481,307 | $124,331,224 | |
| No positions match the current search. | |||||
New Positions
Positions the filer opened this quarter
3 positions
37 tracked positions ·
$3,876,499,965 total
· filing declares
38 positions · $3,886,526,658
· as of Mar 31, 2026
| Ticker | Company | Type | Shares | Value (USD) | % of Portfolio | History |
|---|---|---|---|---|---|---|
| MIRM |
Mirum Pharmaceuticals, Inc.
Healthcare
|
Added | 7,679,684 | $709,449,207 | 18.30% | |
| NAMS |
NewAmsterdam Pharma Co N.V.
Healthcare
|
Held | 16,943,774 | $542,370,205 | 13.99% | |
| ERAS |
Erasca, Inc.
Healthcare
|
Added | 24,675,188 | $399,244,541 | 10.30% | |
| BBIO |
BridgeBio Pharma, Inc.
Healthcare
|
Reduced | 3,448,139 | $256,058,802 | 6.61% | |
| ARQT |
Arcutis Biotherapeutics, Inc.
Healthcare
|
Held | 9,874,511 | $232,643,479 | 6.00% | |
| MBX |
MBX Biosciences, Inc.
Healthcare
|
Held | 6,652,013 | $198,562,588 | 5.12% | |
| PHAT |
Phathom Pharmaceuticals, Inc.
Healthcare
|
Held | 12,466,489 | $138,502,692 | 3.57% | |
| MAZE |
Maze Therapeutics, Inc.
Healthcare
|
Held | 4,567,274 | $136,333,128 | 3.52% | |
| KRYS |
Krystal Biotech, Inc.
Healthcare
|
Reduced | 481,307 | $124,331,224 | 3.21% | |
| TRVI |
Trevi Therapeutics, Inc.
Healthcare
|
Reduced | 9,939,547 | $118,578,795 | 3.06% | |
| PVLA |
Palvella Therapeutics, Inc.
Healthcare
|
Added | 882,400 | $109,991,160 | 2.84% | |
| KALV |
KalVista Pharmaceuticals, Inc.
Healthcare
|
Reduced | 4,961,108 | $99,867,104 | 2.58% | |
| IRON |
Disc Medicine, Inc.
Healthcare
|
Added | 1,354,852 | $86,629,236 | 2.23% | |
| CYTK |
Cytokinetics Inc
Healthcare
|
Added | 1,159,879 | $76,447,624 | 1.97% | |
| RVMD |
Revolution Medicines, Inc.
Healthcare
|
Reduced | 675,686 | $65,710,463 | 1.70% | |
| DYN |
Dyne Therapeutics, Inc.
Healthcare
|
Held | 3,153,082 | $57,165,376 | 1.47% | |
| SVRA |
Savara Inc
Healthcare
|
Reduced | 9,720,852 | $53,075,851 | 1.37% | |
| TARS |
Tarsus Pharmaceuticals, Inc.
Healthcare
|
Held | 728,644 | $51,114,376 | 1.32% | |
| VOR |
Vor Biopharma Inc.
Healthcare
|
Held | 2,543,939 | $45,383,871 | 1.17% | |
| AGIO |
Agios Pharmaceuticals, Inc.
Healthcare
|
Reduced | 1,256,080 | $42,493,186 | 1.10% | |
| BCRX |
Biocryst Pharmaceuticals Inc
Healthcare
|
NEW | 4,009,240 | $38,167,964 | 0.98% | |
| ZLAB |
Zai Lab Ltd
Healthcare
|
Held | 1,902,320 | $35,782,639 | 0.92% | |
| AURA |
Aura Biosciences, Inc.
Healthcare
|
Held | 5,100,000 | $34,119,000 | 0.88% | |
| ACAD |
Acadia Pharmaceuticals Inc
Healthcare
|
Added | 1,438,198 | $32,014,287 | 0.83% | |
| ASND |
Ascendis Pharma A/S
Healthcare
|
Held | 133,333 | $30,497,257 | 0.79% | |
| LXEO |
Lexeo Therapeutics, Inc.
Healthcare
|
Held | 4,424,725 | $25,397,921 | 0.66% | |
| ALKS |
Alkermes plc.
Healthcare
|
Held | 700,647 | $24,774,877 | 0.64% | |
| ACRS |
Aclaris Therapeutics, Inc.
Healthcare
|
NEW | 4,925,374 | $18,470,152 | 0.48% | |
| GLUE |
Monte Rosa Therapeutics, Inc.
Healthcare
|
NEW | 1,000,000 | $16,450,000 | 0.42% | |
| IMCR |
Immunocore Holdings plc
Healthcare
|
Added | 484,782 | $14,616,177 | 0.38% | |
| MNKD |
Mannkind Corp
Healthcare
|
Added | 5,900,000 | $14,455,000 | 0.37% | |
| VALN |
Valneva SE
Healthcare
|
Held | 2,291,666 | $14,322,912 | 0.37% | |
| EOLS |
Evolus, Inc.
Healthcare
|
Held | 2,630,665 | $10,812,033 | 0.28% | |
| ALLO |
Allogene Therapeutics, Inc.
Healthcare
|
Reduced | 3,796,668 | $9,263,869 | 0.24% | |
| AUTL |
Autolus Therapeutics plc
Healthcare
|
Reduced | 4,447,910 | $6,138,115 | 0.16% | |
| IBIO |
iBio, Inc.
Healthcare
|
Held | 1,953,467 | $3,711,587 | 0.10% | |
| XLO |
Xilio Therapeutics, Inc.
Healthcare
|
Reduced | 422,505 | $3,553,267 | 0.09% |
Covers the securities this platform tracks: U.S.-listed common stock and the put/call positions reported on it. A 13F can also report security types outside that coverage — preferred shares, bonds, warrants, untracked share classes — so the filing's own declared total can exceed the figures above. The source filing is linked at the top of this table.