Institutions
JANUS HENDERSON GROUP PLC

JANUS HENDERSON GROUP PLC

CIK

1274173

Location

LONDON, X0

Portfolio Value

Large $42,996,219,975

Diversification

Diversified

Filing Date

Global Rank

#42 / 8,533 ▼ 1

Top Industry

Semiconductors 14.0%

Period ended 2 months ago

Filed May 18, 2026 · 12d

40 quarters · since Sep 2013

Portfolio Concentration

2,316 positions · as of Mar 31, 2026 · Δ vs Dec 31, 2025

Top Position

7.3%

−0.1 pts

Top 5

21.6%

−2.5 pts

Top 10

29.3%

−3.0 pts

HHI

143

Diversified −24

Portfolio Trend

40 quarters · across all stocks

Sector Breakdown

As of Mar 31, 2026

Sector	% Portfolio	Value	Positions
Technology	34.3%	$68,140,096,034	346
Healthcare	21.7%	$42,996,219,975	384
Industrials	11.8%	$23,405,507,036	341
Consumer Cyclical	9.8%	$19,478,018,185	263
Financial Services	8.6%	$17,152,385,895	359
Communication Services	5.0%	$9,939,033,281	83
Energy	2.2%	$4,446,713,128	111
Utilities	1.8%	$3,644,523,408	63
Consumer Defensive	1.6%	$3,268,893,161	99
Basic Materials	1.6%	$3,090,193,529	108
Real Estate	1.5%	$2,905,775,456	153
Unclassified	0.0%	$34,700,534	6

Last Quarter's Activity

Export CSV

Mar 31, 2026 vs Dec 31, 2025

Added To

Positions the filer increased

25 positions

Ticker	Company	Δ Shares	Shares	Value
BHVN	Biohaven Ltd.	+16,127,247	17,534,612	$148,342,815
AUR	Aurora Innovation, Inc.	+10,724,682	11,243,080	$46,321,488
FCX	Freeport-Mcmoran Inc	+5,784,156	11,498,267	$675,868,131
NERV	Minerva Neurosciences, Inc.	+4,285,259	4,294,259	$25,872,910
BSX	Boston Scientific Corp	+3,907,981	16,497,366	$1,035,209,713
RLMD	Relmada Therapeutics, Inc.	+3,793,862	11,063,862	$77,004,479
PCVX	Vaxcyte, Inc.	+3,188,687	16,575,875	$963,224,094
PLTR	Palantir Technologies Inc.	+2,952,079	3,323,141	$486,109,064
DUK	Duke Energy CORP	+2,684,721	2,735,816	$358,227,745
COP	Conocophillips	+2,496,606	3,697,232	$488,034,624
SHC	Sotera Health Co	+2,390,132	9,162,191	$131,385,818
DMRA	Damora Therapeutics, Inc.	+2,360,957	2,362,696	$61,193,826
DKNG	DraftKings Inc.	+2,351,790	27,665,699	$598,132,411
PTCT	Ptc Therapeutics, Inc.	+2,342,101	7,193,433	$490,088,588
GKOS	GLAUKOS Corp	+2,329,608	5,348,395	$575,808,203
TTE	TotalEnergies SE	+2,287,500	11,349,122	$1,032,543,118
DASH	DoorDash, Inc.	+2,225,954	7,762,553	$1,165,547,329
AEP	American Electric Power Co Inc	+2,194,198	2,219,198	$290,892,472
BBIO	BridgeBio Pharma, Inc.	+2,178,556	13,179,013	$978,673,503
GPGI	GPGI, Inc.	+2,096,976	2,116,195	$36,186,934
GERN	Geron Corp	+1,978,839	2,218,196	$3,305,111
RXT	Rackspace Technology, Inc.	+1,887,317	2,937,670	$2,878,916
BIOA	BioAge Labs, Inc.	+1,685,063	2,094,270	$36,628,782
TENX	Tenax Therapeutics, Inc.	+1,648,808	1,815,474	$29,029,429
SO	Southern Co	+1,636,051	1,713,552	$165,392,037
No positions match the current search.

Trimmed

Positions the filer reduced

25 positions

Ticker	Company	Δ Shares	Shares	Value
DB	Deutsche Bank Aktiengesellschaft	−6,261,957	676,223	$20,137,920
ARDX	Ardelyx, Inc.	−6,143,458	8,371,234	$50,143,690
SSNC	SS&C Technologies Holdings Inc	−5,592,063	8,425,246	$569,293,869
PFE	Pfizer Inc	−5,562,370	3,223,714	$90,521,888
MNST	Monster Beverage Corp	−4,862,497	6,760,471	$489,863,727
SCHW	Schwab Charles Corp	−4,787,886	2,074,704	$194,980,680
OCUL	Ocular Therapeutix, Inc	−4,160,702	68,500	$580,195
MFC	Manulife Financial Corp	−3,844,447	201,041	$6,923,851
ADMA	Adma Biologics, Inc.	−3,838,158	98,261	$885,331
BX	Blackstone Inc.	−3,786,019	4,466,274	$513,576,846
WDAY	Workday, Inc.	−3,344,111	1,673,794	$217,459,315
CNQ	Canadian Natural Resources Ltd	−3,194,318	4,301,460	$209,610,143
CPNG	Coupang, Inc.	−2,990,379	39,559	$746,873
MSFT	Microsoft Corp	−2,919,517	23,878,982	$8,839,282,764
MICC	Magnum Ice Cream Co N.V.	−2,721,985	283,065	$4,231,821
RVMD	Revolution Medicines, Inc.	−2,537,006	9,766,496	$949,791,733
ORCL	Oracle Corp	−2,492,952	12,046,414	$1,772,147,961
NBP	NovaBridge Biosciences	−2,403,991	6,032,650	$14,840,319
PBA	Pembina Pipeline Corp	−2,384,707	243,857	$10,915,039
JBI	Janus International Group, Inc.	−2,362,771	354,174	$1,823,995
HR	Healthcare Realty Trust Inc	−2,235,257	145,123	$2,465,639
CWAN	Clearwater Analytics Holdings, Inc.	−2,163,796	1,318,897	$31,191,914
DELL	Dell Technologies Inc.	−2,125,222	528,840	$86,798,507
VICI	Vici Properties Inc.	−2,110,773	464,856	$12,699,864
TERN	Terns Pharmaceuticals, Inc.	−1,909,512	1,470,057	$77,501,404
No positions match the current search.

New Positions

Positions the filer opened this quarter

25 positions

Ticker	Company	Shares	Value
AZN	Astrazeneca PLC	11,949,424	$2,356,665,399
FPS	Forgent Power Solutions, Inc.	7,769,612	$227,416,542
AMCR	Amcor plc	3,545,337	$140,927,145
ARM	Arm Holdings PLC /Uk	767,534	$116,112,543
CCEP	COCA-COLA EUROPACIFIC PARTNERS plc	1,070,753	$97,085,172
DFTX	Definium Therapeutics, Inc.	3,556,041	$67,209,174
ERAS	Erasca, Inc.	3,710,966	$60,043,429
ALMS	Alumis Inc.	2,124,408	$46,800,708
JBIO	Jade Biosciences, Inc.	3,105,669	$43,634,649
JAN	Janus Living, Inc.	1,359,808	$32,050,673
SUNB	Sunbelt Rentals Holdings, Inc.	488,181	$31,775,700
SLDB	Solid Biosciences Inc.	4,010,695	$28,877,004
AKTS	Aktis Oncology, Inc.	1,454,267	$26,016,836
HBM	Hudbay Minerals Inc.	1,243,668	$25,992,661
OVID	Ovid Therapeutics Inc.	10,714,000	$23,785,080
SEPN	Septerna, Inc.	890,754	$21,404,818
EVMN	Evommune, Inc.	896,700	$20,615,133
PMN	ProMIS Neurosciences Inc.	1,292,757	$16,418,013
QGEN	Qiagen N.V.	366,661	$14,681,106
IAG	Iamgold Corp	694,233	$13,065,464
GLUE	Monte Rosa Therapeutics, Inc.	685,926	$11,283,482
UUUU	Energy Fuels Inc	537,003	$9,800,304
SN	SharkNinja, Inc.	69,458	$7,355,602
OFRM	Once Upon a Farm, PBC	445,999	$7,292,083
BOBS	Bob's Discount Furniture, Inc.	543,861	$6,390,366
No positions match the current search.

Sold Out

Positions the filer fully exited

25 positions

Ticker	Company	Shares	Value
ASND	Ascendis Pharma A/S	4,061,641	$866,104,325
TCOM	Trip.com Group Ltd	1,592,109	$114,488,557
BABA	Alibaba Group Holding Ltd	557,742	$81,753,822
UPB	Upstream Bio, Inc.	1,527,958	$41,484,059
HOLX	HOLOGIC INC	511,314	$38,087,778
ENGN	enGene Therapeutics Inc.	1,900,000	$17,157,000
CRCL	Circle Internet Group, Inc.	213,333	$16,917,306
WLTH	Wealthfront Corp	1,015,000	$13,793,849
PEPG	PepGen Inc.	1,500,000	$9,765,000
ORLA	Orla Mining Ltd.	712,500	$9,597,375
EXAS	EXACT SCIENCES CORP	84,510	$8,582,835
FLNG	Flex LNG Ltd.	268,516	$6,699,474
GLOB	Globant S.A.	99,328	$6,493,071
VZLA	Vizsla Silver Corp.	979,063	$5,355,473
FUBO	FuboTV Inc.	172,700	$5,222,448
PIPR	Piper Sandler Companies	51,697	$4,390,496
PLOW	Douglas Dynamics, Inc	79,494	$2,595,478
VTEX	Vtex	685,138	$2,576,118
SITC	SITE Centers Corp.	392,649	$2,520,806
AQST	Aquestive Therapeutics, Inc.	226,702	$1,464,494
TGNA	TEGNA INC	69,095	$1,341,133
AKBA	Akebia Therapeutics, Inc.	704,020	$1,133,471
NUTX	Nutex Health Inc.	6,655	$1,095,546
MNDY	monday.com Ltd.	6,741	$994,701
SLP	Simulations Plus, Inc.	53,362	$972,789
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

384 positions · $42,996,219,975 total · Healthcare only · as of Mar 31, 2026

All sectors Basic Materials Communication Services Consumer Cyclical Consumer Defensive Energy Financial Services Healthcare Industrials Real Estate Technology Utilities

Showing 1–50 of 384 positions by value · page 1 of 8

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	% of Portfolio
LLY	ELI LILLY & Co Healthcare	Reduced	4,347,394	-94,583	$3,998,602,577	−16.2%	9.30%
AZN	Astrazeneca PLC Healthcare	NEW	11,949,424	NEW	$2,356,665,399	NEW	5.48%
JNJ	Johnson & Johnson Healthcare	Added	7,872,478	+148,497	$1,924,348,519	+20.4%	4.48%
ARGX	Argenx SE Healthcare	Added	2,541,732	+83,568	$1,856,099,791	−10.2%	4.32%
ABBV	AbbVie Inc. Healthcare	Added	6,931,036	+528,386	$1,507,431,018	+3.0%	3.51%
DHR	Danaher Corp /De/ Healthcare	Reduced	6,489,965	-327,641	$1,230,497,361	−21.2%	2.86%
PRAX	Praxis Precision Medicines, Inc. Healthcare	Added	3,458,863	+218,777	$1,114,411,067	+16.7%	2.59%
MDGL	Madrigal Pharmaceuticals, Inc. Healthcare	Added	2,018,647	+433,804	$1,056,701,142	+14.5%	2.46%
BSX	Boston Scientific Corp Healthcare	Added	16,497,366	+3,907,981	$1,035,209,713	−13.8%	2.41%
UNH	Unitedhealth Group Inc Healthcare	Added	3,691,607	+89,359	$998,911,936	−16.0%	2.32%
BBIO	BridgeBio Pharma, Inc. Healthcare	Added	13,179,013	+2,178,556	$978,673,503	+16.3%	2.28%
PCVX	Vaxcyte, Inc. Healthcare	Added	16,575,875	+3,188,687	$963,224,094	+55.9%	2.24%
VRTX	Vertex Pharmaceuticals Inc / Ma Healthcare	Reduced	2,131,527	-90,426	$951,812,064	−5.5%	2.21%
RVMD	Revolution Medicines, Inc. Healthcare	Reduced	9,766,496	-2,537,006	$949,791,733	−3.1%	2.21%
ABT	Abbott Laboratories Healthcare	Added	8,092,917	+641,375	$830,899,786	−11.0%	1.93%
ISRG	Intuitive Surgical Inc Healthcare	Added	1,643,060	+58,587	$757,434,227	−15.6%	1.76%
RVTY	Revvity, Inc. Healthcare	Added	8,348,127	+186,956	$731,379,403	−7.4%	1.70%
GMED	Globus Medical Inc Healthcare	Added	7,623,095	+328,217	$656,805,862	+3.1%	1.53%
SYK	Stryker Corp Healthcare	Reduced	1,958,916	-116,420	$643,680,206	−11.8%	1.50%
MIRM	Mirum Pharmaceuticals, Inc. Healthcare	Added	6,945,813	+880,505	$641,654,204	+33.9%	1.49%
GKOS	GLAUKOS Corp Healthcare	Added	5,348,395	+2,329,608	$575,808,203	+68.9%	1.34%
MCK	Mckesson Corp Healthcare	Reduced	628,945	-89,115	$544,263,844	−7.6%	1.27%
UTHR	UNITED THERAPEUTICS Corp Healthcare	Added	866,930	+70,829	$514,072,149	+32.5%	1.20%
TFX	Teleflex Inc Healthcare	Added	4,291,311	+45,199	$513,283,706	−0.9%	1.19%
MDLN	Medline Inc. Healthcare	Added	11,451,861	+887,240	$509,607,814	+14.9%	1.19%
PTCT	Ptc Therapeutics, Inc. Healthcare	Added	7,193,433	+2,342,101	$490,088,588	+33.0%	1.14%
WAT	Waters Corp /De/ Healthcare	Added	1,638,772	+348,379	$488,026,298	−0.4%	1.14%
HCA	HCA Healthcare, Inc. Healthcare	Reduced	1,017,441	-72,449	$481,493,777	−5.4%	1.12%
ZTS	Zoetis Inc. Healthcare	Reduced	3,701,747	-182,365	$437,583,511	−10.5%	1.02%
STE	STERIS plc Healthcare	Added	1,863,139	+380,504	$411,995,924	+9.6%	0.96%
AMGN	Amgen Inc Healthcare	Reduced	1,107,159	-1,215,634	$389,553,892	−48.8%	0.91%
LNTH	Lantheus Holdings, Inc. Healthcare	Reduced	4,774,841	-932,406	$362,171,687	−4.6%	0.84%
NVS	Novartis AG Healthcare	Added	2,275,938	+41,520	$347,649,529	+12.9%	0.81%
MRK	Merck & Co., Inc. Healthcare	Added	2,880,199	+995,059	$346,459,135	+74.6%	0.81%
ICUI	Icu Medical Inc/De Healthcare	Added	2,676,012	+99,256	$345,606,947	−6.0%	0.80%
TVTX	Travere Therapeutics, Inc. Healthcare	Added	11,419,586	+908,420	$339,275,898	−15.5%	0.79%
TMO	Thermo Fisher Scientific Inc. Healthcare	Reduced	660,258	-436,701	$324,536,613	−48.9%	0.75%
PTGX	Protagonist Therapeutics, Inc Healthcare	Added	2,891,527	+241,546	$304,766,945	+31.7%	0.71%
GILD	Gilead Sciences, Inc. Healthcare	Added	1,972,639	+110,525	$274,926,696	+20.3%	0.64%
ILMN	Illumina, Inc. Healthcare	Added	2,100,638	+29,094	$258,924,637	−4.7%	0.60%
GPCR	Structure Therapeutics Inc. Healthcare	Added	5,354,981	+264,833	$258,110,082	−27.1%	0.60%
CVS	CVS HEALTH Corp Healthcare	Reduced	3,536,861	-80,085	$254,017,356	−11.5%	0.59%
DYN	Dyne Therapeutics, Inc. Healthcare	Reduced	13,647,376	-240,346	$247,426,926	−8.9%	0.58%
MDT	Medtronic plc Healthcare	Reduced	2,835,816	-278,342	$245,723,455	−17.9%	0.57%
XENE	Xenon Pharmaceuticals Inc. Healthcare	Added	4,175,982	+91,948	$242,833,352	+32.7%	0.56%
IDYA	IDEAYA Biosciences, Inc. Healthcare	Added	7,265,253	+78,797	$242,078,229	−2.6%	0.56%
SLNO	Soleno Therapeutics Inc Healthcare	Reduced	7,099,328	-79,026	$237,685,500	−28.5%	0.55%
COGT	Cogent Biosciences, Inc. Healthcare	Added	5,965,125	+1,427,717	$229,597,660	+42.5%	0.53%
COO	Cooper Companies, Inc. Healthcare	Reduced	3,067,125	-39,280	$219,299,437	−13.9%	0.51%
LGND	Ligand Pharmaceuticals Inc Healthcare	Added	1,009,891	+14,491	$201,624,736	+7.1%	0.47%

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