DAFNA Capital Management LLC
Filing Date
Global Rank
#3,038
/ 8,622
▲ 118
· as of Mar 2026
Top Industry
Biotechnology
69.7%
3Y Alpha vs SPY
+8.6%
Period ended 4 months ago
Filed May 15, 2026 · 2mo
25 quarters · since Mar 2020
Clone Performance
Jul 2023–Jul 2026 · vs SPYHypothetical growth of buying every stock this filer reported holding, rebalancing on each filing and indexed to the same start. Option positions cannot be bought this way and are left out.
Cloned portfolio
+114.6%
SPY
+67.9%
Annualised alpha
+10.1%
Max drawdown
−42.5%
Estimate. 13F holdings are quarter-lagged, so the clone rebalances about 45 days after each period end — when the filing becomes public — and it excludes option and short positions. It tracks 100% of reported value on average across 13 quarters. Past performance does not predict future results.
Portfolio Concentration
80 tracked positions · as of Mar 31, 2026 · Δ vs Dec 31, 2025Top Position
14.8%
+1.7 pts
Top 5
35.4%
−3.8 pts
Top 10
52.1%
−3.3 pts
HHI
444
Diversified−9
Portfolio Trend
25 quarters · across all stocks
Sector Breakdown
As of Mar 31, 2026| Sector | % Portfolio | Value |
|---|---|---|
| Healthcare | 100.0% | $382,816,655 |
Last Quarter's Activity
Export CSVAdded To
Positions the filer increased
20 positions
| Ticker | Company | Δ Shares | Shares | Value | Open |
|---|---|---|---|---|---|
| CMPS | COMPASS Pathways plc | +1,607,836 | 2,418,882 | $13,376,417 | |
| LRMR | Larimar Therapeutics, Inc. | +1,090,000 | 2,029,164 | $9,131,238 | |
| ARAY | Accuray Inc | +285,000 | 1,680,508 | $655,398 | |
| BCAX | Bicara Therapeutics Inc. | +160,150 | 421,733 | $8,388,269 | |
| NKTR | Nektar Therapeutics | +90,180 | 165,178 | $11,884,557 | |
| RARE | Ultragenyx Pharmaceutical Inc. | +45,100 | 61,100 | $1,280,045 | |
| HELP | Cybin Inc. | +43,343 | 498,361 | $2,392,132 | |
| LXEO | Lexeo Therapeutics, Inc. | +36,200 | 377,059 | $2,164,318 | |
| NGNE | Neurogene Inc. | +28,661 | 56,635 | $1,141,761 | |
| MPLT | MapLight Therapeutics, Inc. | +27,242 | 171,006 | $3,476,551 | |
| ENGN | enGene Therapeutics Inc. | +23,708 | 187,353 | $1,275,873 | |
| STOK | Stoke Therapeutics, Inc. | +22,000 | 130,875 | $4,261,290 | |
| INGN | Inogen Inc | +18,108 | 845,179 | $5,223,206 | |
| RCUS | Arcus Biosciences, Inc. | +12,500 | 443,829 | $9,586,706 | |
| BCRX | Biocryst Pharmaceuticals Inc | +11,993 | 430,248 | $4,095,960 | |
| MBX | MBX Biosciences, Inc. | +10,200 | 175,465 | $5,237,630 | |
| INSP | Inspire Medical Systems, Inc. | +9,600 | 18,200 | $938,756 | |
| GPCR | Structure Therapeutics Inc. | +9,500 | 46,500 | $2,241,300 | |
| ALKS | Alkermes plc. | +9,234 | 139,482 | $4,932,083 | |
| PODD | Insulet Corp | +4,000 | 10,870 | $2,280,960 | |
| No positions match the current search. | |||||
Trimmed
Positions the filer reduced
25 positions
| Ticker | Company | Δ Shares | Shares | Value | Open |
|---|---|---|---|---|---|
| IPSC | Century Therapeutics, Inc. | −359,233 | 2,434,353 | $5,501,637 | |
| AXGN | Axogen, Inc. | −226,866 | 249,960 | $8,281,174 | |
| ANNX | Annexon, Inc. | −155,000 | 117,812 | $652,678 | |
| CYTK | Cytokinetics Inc | −153,500 | 217,497 | $14,335,227 | |
| BHVN | Biohaven Ltd. | −109,500 | 845,735 | $7,154,918 | |
| KALV | KalVista Pharmaceuticals, Inc. | −89,400 | 267,402 | $5,382,802 | |
| SNDX | Syndax Pharmaceuticals Inc | −60,500 | 217,355 | $5,077,412 | |
| SPRY | ARS Pharmaceuticals, Inc. | −50,780 | 139,285 | $1,118,458 | |
| EWTX | Edgewise Therapeutics, Inc. | −47,500 | 112,236 | $3,535,434 | |
| ORIC | Oric Pharmaceuticals, Inc. | −42,321 | 98,724 | $1,250,833 | |
| XENE | Xenon Pharmaceuticals Inc. | −37,167 | 250,772 | $14,582,391 | |
| IMTX | Immatics N.V. | −35,278 | 225,860 | $2,222,462 | |
| IDYA | IDEAYA Biosciences, Inc. | −30,000 | 476,740 | $15,884,976 | |
| RVMD | Revolution Medicines, Inc. | −23,836 | 580,678 | $56,470,935 | |
| PROF | Profound Medical Corp. | −22,705 | 263,005 | $1,704,272 | |
| DAWN | Day One Biopharmaceuticals, Inc. | −20,700 | 978,463 | $20,978,246 | |
| VRCA | Verrica Pharmaceuticals Inc. | −19,739 | 153,712 | $813,136 | |
| MDWD | MediWound Ltd. | −19,207 | 94,405 | $1,520,864 | |
| FHTX | Foghorn Therapeutics Inc. | −15,000 | 111,859 | $534,686 | |
| CGEN | Compugen Ltd | −14,619 | 257,783 | $549,077 | |
| ALLO | Allogene Therapeutics, Inc. | −10,000 | 1,370,118 | $3,343,087 | |
| AQST | Aquestive Therapeutics, Inc. | −7,500 | 368,415 | $1,528,922 | |
| KPTI | Karyopharm Therapeutics Inc. | −5,200 | 45,800 | $255,106 | |
| ASND | Ascendis Pharma A/S | −5,000 | 23,177 | $5,301,275 | |
| ADCT | ADC Therapeutics SA | −5,000 | 72,081 | $270,303 | |
| No positions match the current search. | |||||
New Positions
Positions the filer opened this quarter
10 positions
| Ticker | Company | Shares | Value | Open |
|---|---|---|---|---|
| FULC | Fulcrum Therapeutics, Inc. | 205,000 | $1,572,350 | |
| KIDS | Orthopediatrics Corp | 95,659 | $1,518,108 | |
| CTMX | CytomX Therapeutics, Inc. | 230,000 | $1,081,000 | |
| MAZE | Maze Therapeutics, Inc. | 35,000 | $1,044,750 | |
| SCYX | Scynexis Inc | 1,086,956 | $996,738 | |
| ZBIO | Zenas BioPharma, Inc. | 42,500 | $830,875 | |
| NAMS | NewAmsterdam Pharma Co N.V. | 20,000 | $640,200 | |
| PLRX | Pliant Therapeutics, Inc. | 487,000 | $613,620 | |
| IBIO | iBio, Inc. | 193,638 | $367,912 | |
| NMRA | Neumora Therapeutics, Inc. | 70,000 | $136,500 | |
| No positions match the current search. | ||||
80 tracked positions ·
$382,816,655 total
· filing declares
83 positions · $439,591,894
· as of Mar 31, 2026
Showing 1–50
of 80 positions by value
· page 1 of 2
| Ticker | Company | Type | Shares | Value (USD) | % of Portfolio | History |
|---|---|---|---|---|---|---|
| RVMD |
Revolution Medicines, Inc.
Healthcare
|
Reduced | 580,678 | $56,470,935 | 14.75% | |
| STXS |
Stereotaxis, Inc.
Healthcare
|
Held | 13,680,554 | $25,172,219 | 6.58% | |
| DAWN |
Day One Biopharmaceuticals, Inc.
Healthcare
|
Reduced | 978,463 | $20,978,246 | 5.48% | |
| ATRC |
AtriCure, Inc.
Healthcare
|
Held | 597,431 | $17,044,706 | 4.45% | |
| IDYA |
IDEAYA Biosciences, Inc.
Healthcare
|
Reduced | 476,740 | $15,884,976 | 4.15% | |
| XENE |
Xenon Pharmaceuticals Inc.
Healthcare
|
Reduced | 250,772 | $14,582,391 | 3.81% | |
| CYTK |
Cytokinetics Inc
Healthcare
|
Reduced | 217,497 | $14,335,227 | 3.74% | |
| CMPS |
COMPASS Pathways plc
Healthcare
|
Added | 2,418,882 | $13,376,417 | 3.49% | |
| NKTR |
Nektar Therapeutics
Healthcare
|
Added | 165,178 | $11,884,557 | 3.10% | |
| RCUS |
Arcus Biosciences, Inc.
Healthcare
|
Added | 443,829 | $9,586,706 | 2.50% | |
| NBIX |
Neurocrine Biosciences Inc
Healthcare
|
Held | 70,615 | $9,302,820 | 2.43% | |
| LRMR |
Larimar Therapeutics, Inc.
Healthcare
|
Added | 2,029,164 | $9,131,238 | 2.39% | |
| BCAX |
Bicara Therapeutics Inc.
Healthcare
|
Added | 421,733 | $8,388,269 | 2.19% | |
| AXGN |
Axogen, Inc.
Healthcare
|
Reduced | 249,960 | $8,281,174 | 2.16% | |
| BHVN |
Biohaven Ltd.
Healthcare
|
Reduced | 845,735 | $7,154,918 | 1.87% | |
| TNDM |
Tandem Diabetes Care Inc
Healthcare
|
Held | 355,208 | $6,809,337 | 1.78% | |
| DNLI |
Denali Therapeutics Inc.
Healthcare
|
Held | 318,500 | $6,115,200 | 1.60% | |
| IPSC |
Century Therapeutics, Inc.
Healthcare
|
Reduced | 2,434,353 | $5,501,637 | 1.44% | |
| DXCM |
Dexcom Inc
Healthcare
|
Reduced | 86,279 | $5,418,321 | 1.42% | |
| KALV |
KalVista Pharmaceuticals, Inc.
Healthcare
|
Reduced | 267,402 | $5,382,802 | 1.41% | |
| ASND |
Ascendis Pharma A/S
Healthcare
|
Reduced | 23,177 | $5,301,275 | 1.38% | |
| MBX |
MBX Biosciences, Inc.
Healthcare
|
Added | 175,465 | $5,237,630 | 1.37% | |
| INGN |
Inogen Inc
Healthcare
|
Added | 845,179 | $5,223,206 | 1.36% | |
| SNDX |
Syndax Pharmaceuticals Inc
Healthcare
|
Reduced | 217,355 | $5,077,412 | 1.33% | |
| ALKS |
Alkermes plc.
Healthcare
|
Added | 139,482 | $4,932,083 | 1.29% | |
| STOK |
Stoke Therapeutics, Inc.
Healthcare
|
Added | 130,875 | $4,261,290 | 1.11% | |
| BCRX |
Biocryst Pharmaceuticals Inc
Healthcare
|
Added | 430,248 | $4,095,960 | 1.07% | |
| LKFT |
Lakefront Biotherapeutics NV
Healthcare
|
Held | 130,175 | $3,905,250 | 1.02% | |
| IMVT |
Immunovant, Inc.
Healthcare
|
Held | 150,524 | $3,739,016 | 0.98% | |
| EWTX |
Edgewise Therapeutics, Inc.
Healthcare
|
Reduced | 112,236 | $3,535,434 | 0.92% | |
| MPLT |
MapLight Therapeutics, Inc.
Healthcare
|
Added | 171,006 | $3,476,551 | 0.91% | |
| ALLO |
Allogene Therapeutics, Inc.
Healthcare
|
Reduced | 1,370,118 | $3,343,087 | 0.87% | |
| PRCT |
PROCEPT BioRobotics Corp
Healthcare
|
Held | 120,000 | $3,001,200 | 0.78% | |
| ALGN |
Align Technology Inc
Healthcare
|
Reduced | 15,000 | $2,571,450 | 0.67% | |
| PRQR |
ProQR Therapeutics N.V.
Healthcare
|
Held | 1,567,561 | $2,539,448 | 0.66% | |
| HELP |
Cybin Inc.
Healthcare
|
Added | 498,361 | $2,392,132 | 0.62% | |
| RAPP |
Rapport Therapeutics, Inc.
Healthcare
|
Held | 75,000 | $2,346,750 | 0.61% | |
| PODD |
Insulet Corp
Healthcare
|
Added | 10,870 | $2,280,960 | 0.60% | |
| GPCR |
Structure Therapeutics Inc.
Healthcare
|
Added | 46,500 | $2,241,300 | 0.59% | |
| IMTX |
Immatics N.V.
Healthcare
|
Reduced | 225,860 | $2,222,462 | 0.58% | |
| CLDX |
Celldex Therapeutics, Inc.
Healthcare
|
Held | 68,518 | $2,173,390 | 0.57% | |
| LXEO |
Lexeo Therapeutics, Inc.
Healthcare
|
Added | 377,059 | $2,164,318 | 0.57% | |
| ALEC |
Alector, Inc.
Healthcare
|
Held | 908,351 | $1,952,954 | 0.51% | |
| VKTX |
Viking Therapeutics, Inc.
Healthcare
|
Held | 59,516 | $1,936,650 | 0.51% | |
| KURA |
Kura Oncology, Inc.
Healthcare
|
Held | 235,868 | $1,917,606 | 0.50% | |
| PROF |
Profound Medical Corp.
Healthcare
|
Reduced | 263,005 | $1,704,272 | 0.45% | |
| FULC |
Fulcrum Therapeutics, Inc.
Healthcare
|
NEW | 205,000 | $1,572,350 | 0.41% | |
| AQST |
Aquestive Therapeutics, Inc.
Healthcare
|
Reduced | 368,415 | $1,528,922 | 0.40% | |
| MDWD |
MediWound Ltd.
Healthcare
|
Reduced | 94,405 | $1,520,864 | 0.40% | |
| KIDS |
Orthopediatrics Corp
Healthcare
|
NEW | 95,659 | $1,518,108 | 0.40% |
Covers the securities this platform tracks: U.S.-listed common stock and the put/call positions reported on it. A 13F can also report security types outside that coverage — preferred shares, bonds, warrants, untracked share classes — so the filing's own declared total can exceed the figures above. The source filing is linked at the top of this table.