Opaleye Management Inc.

CIK

1595855

Location

Boston, MA

Portfolio Value

Small $743,833,828

Diversification

Diversified

Filing Date

Global Rank

#2,102 / 8,586 ▲ 43

Top Industry

Biotechnology 57.5%

3Y Alpha vs SPY

+19.0%

Period ended 3 months ago

Filed May 15, 2026 · 32d

25 quarters · since Mar 2020

Clone Performance

Jun 2023–Jun 2026 · vs SPY

Hypothetical growth of cloning every reported 13F position and rebalancing on each filing, indexed to the same start.

Cloned portfolio

+175.8%

SPY

+78.1%

Annualised alpha

+19.0%

Max drawdown

−42.1%

Estimate. 13F holdings are quarter-lagged and long-only, so the clone rebalances about 45 days after each period end — when the filing becomes public — and excludes options and short positions. Past performance does not predict future results.

Portfolio Concentration

53 positions · as of Mar 31, 2026 · Δ vs Dec 31, 2025

Top Position

13.4%

−12.1 pts

Top 5

45.6%

−6.3 pts

Top 10

61.6%

−4.6 pts

HHI

593

Diversified−353

Portfolio Trend

25 quarters · across all stocks

Sector Breakdown

As of Mar 31, 2026

Sector	% Portfolio	Value	Positions
Healthcare	100.0%	$743,833,828	53

Last Quarter's Activity

Export CSV

Mar 31, 2026 vs Dec 31, 2025

Added To

Positions the filer increased

18 positions

Ticker	Company	Δ Shares	Shares	Value
CATX	Perspective Therapeutics, Inc.	+3,490,500	4,675,000	$19,494,750
MGTX	MeiraGTx Holdings plc	+1,732,415	2,123,259	$18,387,422
URGN	UroGen Pharma Ltd.	+1,161,577	1,430,000	$25,711,400
QTTB	Q32 Bio Inc.	+1,042,865	1,256,228	$8,064,983
ACOG	Alpha Cognition Inc.	+491,166	2,561,950	$14,065,105
CABA	Cabaletta Bio, Inc.	+480,000	1,380,000	$3,712,200
IRON	Disc Medicine, Inc.	+221,000	421,000	$26,918,740
AVIR	Atea Pharmaceuticals, Inc.	+142,785	322,600	$1,735,588
CBIO	Crescent Biopharma, Inc.	+134,315	1,312,615	$24,112,737
LQDA	Liquidia Corp	+110,000	2,545,000	$96,048,300
ENTA	Enanta Pharmaceuticals Inc	+50,000	125,000	$1,578,750
SLGL	Sol-Gel Technologies Ltd.	+46,261	500,000	$39,610,000
ALMS	Alumis Inc.	+15,000	550,000	$12,116,500
RZLT	Rezolute, Inc.	+12,844	6,300,000	$19,215,000
ZNTL	Zentalis Pharmaceuticals, Inc.	+11,750	1,412,656	$3,305,615
XOMA	XOMA Royalty Corp	+7,410	300,000	$9,411,000
STOK	Stoke Therapeutics, Inc.	+5,000	700,000	$22,792,000
APGE	Apogee Therapeutics, Inc.	+1,743	390,000	$32,826,300
No positions match the current search.

Trimmed

Positions the filer reduced

12 positions

Ticker	Company	Δ Shares	Shares	Value
PLX	Protalix BioTherapeutics, Inc.	−2,138,176	340,000	$737,800
HROW	Harrow, Inc.	−1,072,770	2,832,230	$99,864,429
OCUL	Ocular Therapeutix, Inc	−995,000	600,000	$5,082,000
CGON	CG Oncology, Inc.	−315,200	94,800	$6,416,064
ANNX	Annexon, Inc.	−268,239	2,331,761	$12,917,955
RYTM	Rhythm Pharmaceuticals, Inc.	−207,000	123,000	$10,697,310
TECX	Tectonic Therapeutic, Inc.	−91,747	123,000	$3,801,930
FBIO	Fortress Biotech, Inc.	−48,000	1,042,000	$2,907,180
VYGR	Voyager Therapeutics, Inc.	−46,904	1,150,000	$4,439,000
DERM	Journey Medical Corp	−15,000	960,000	$4,502,400
PTGX	Protagonist Therapeutics, Inc	−5,000	100,000	$10,540,000
CDXS	Codexis, Inc.	−4,738	6,785,000	$11,059,550
No positions match the current search.

New Positions

Positions the filer opened this quarter

9 positions

Ticker	Company	Shares	Value
ASRT	Assertio Holdings, Inc.	265,707	$5,064,375
EDIT	Editas Medicine, Inc.	1,926,997	$4,759,682
BDSX	Biodesix Inc	238,047	$3,451,681
NTLA	Intellia Therapeutics, Inc.	245,000	$3,140,900
LYEL	Lyell Immunopharma, Inc.	79,097	$1,586,685
NXTC	NextCure, Inc.	141,181	$1,507,813
FDMT	4D Molecular Therapeutics, Inc.	112,291	$1,045,429
BBOT	BridgeBio Oncology Therapeutics, Inc.	53,282	$476,873
LBRX	Lb Pharmaceuticals Inc	14,506	$357,717
No positions match the current search.

Sold Out

Positions the filer fully exited

6 positions

Ticker	Company	Shares	Value
ALKS	Alkermes plc.	490,000	$13,710,200
GOSS	Gossamer Bio, Inc.	2,720,000	$8,432,000
KPTI	Karyopharm Therapeutics Inc.	930,000	$6,844,800
ZYME	Zymeworks Inc.	108,929	$2,868,100
BBIO	BridgeBio Pharma, Inc.	18,319	$1,401,220
SLN	Silence Therapeutics plc	78,926	$479,870
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

53 positions · $743,833,828 total · as of Mar 31, 2026

All sectors Healthcare

Showing 1–50 of 53 positions by value · page 1 of 2

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	% of Portfolio
HROW	Harrow, Inc. Healthcare	Reduced	2,832,230	-1,072,770	$99,864,429	−47.8%	13.43%
LQDA	Liquidia Corp Healthcare	Added	2,545,000	+110,000	$96,048,300	+14.4%	12.91%
ETON	Eton Pharmaceuticals, Inc. Healthcare	Held	2,860,000	0	$70,584,800	+45.9%	9.49%
SLGL	Sol-Gel Technologies Ltd. Healthcare	Added	500,000	+46,261	$39,610,000	+107.2%	5.33%
APGE	Apogee Therapeutics, Inc. Healthcare	Added	390,000	+1,743	$32,826,300	+12.0%	4.41%
IRON	Disc Medicine, Inc. Healthcare	Added	421,000	+221,000	$26,918,740	+69.5%	3.62%
URGN	UroGen Pharma Ltd. Healthcare	Added	1,430,000	+1,161,577	$25,711,400	+309.0%	3.46%
CBIO	Crescent Biopharma, Inc. Healthcare	Added	1,312,615	+134,315	$24,112,737	+72.5%	3.24%
STOK	Stoke Therapeutics, Inc. Healthcare	Added	700,000	+5,000	$22,792,000	+3.3%	3.06%
CATX	Perspective Therapeutics, Inc. Healthcare	Added	4,675,000	+3,490,500	$19,494,750	+498.5%	2.62%
RZLT	Rezolute, Inc. Healthcare	Added	6,300,000	+12,844	$19,215,000	+29.5%	2.58%
MGTX	MeiraGTx Holdings plc Healthcare	Added	2,123,259	+1,732,415	$18,387,422	+491.8%	2.47%
TGTX	Tg Therapeutics, Inc. Healthcare	Held	535,000	0	$17,772,700	+11.4%	2.39%
SNWV	SANUWAVE Health, Inc. Healthcare	Held	981,267	0	$16,966,106	−42.1%	2.28%
EWTX	Edgewise Therapeutics, Inc. Healthcare	Held	500,000	0	$15,750,000	+26.9%	2.12%
ACOG	Alpha Cognition Inc. Healthcare	Reduced	2,561,950	-1,579,618	$14,065,105	−47.8%	1.89%
ANNX	Annexon, Inc. Healthcare	Reduced	2,331,761	-268,239	$12,917,955	−1.0%	1.74%
ALMS	Alumis Inc. Healthcare	Added	550,000	+15,000	$12,116,500	+132.0%	1.63%
CDXS	Codexis, Inc. Healthcare	Reduced	6,785,000	-6,794,476	$11,059,550	−50.0%	1.49%
RYTM	Rhythm Pharmaceuticals, Inc. Healthcare	Reduced	123,000	-207,000	$10,697,310	−69.7%	1.44%
PTGX	Protagonist Therapeutics, Inc Healthcare	Reduced	100,000	-5,000	$10,540,000	+14.9%	1.42%
RVMD	Revolution Medicines, Inc. Healthcare	Held	100,000	0	$9,725,000	+22.1%	1.31%
XOMA	XOMA Royalty Corp Healthcare	Added	300,000	+7,410	$9,411,000	+21.0%	1.27%
QTTB	Q32 Bio Inc. Healthcare	Added	1,256,228	+1,042,865	$8,064,983	+1038.5%	1.08%
MBX	MBX Biosciences, Inc. Healthcare	Held	260,000	0	$7,761,000	−5.4%	1.04%
RLMD	Relmada Therapeutics, Inc. Healthcare	Held	935,000	0	$6,507,600	+44.1%	0.87%
CGON	CG Oncology, Inc. Healthcare	Reduced	94,800	-315,200	$6,416,064	−62.3%	0.86%
JBIO	Jade Biosciences, Inc. Healthcare	Held	427,608	0	$6,007,892	−8.9%	0.81%
IRD	Opus Genetics, Inc. Healthcare	Held	1,120,000	0	$5,096,000	+126.4%	0.69%
OCUL	Ocular Therapeutix, Inc Healthcare	Reduced	600,000	-995,000	$5,082,000	−73.8%	0.68%
ASRT	Assertio Holdings, Inc. Healthcare	NEW	265,707	NEW	$5,064,375	NEW	0.68%
EDIT	Editas Medicine, Inc. Healthcare	NEW	1,926,997	NEW	$4,759,682	NEW	0.64%
STRO	Sutro Biopharma, Inc. Healthcare	Held	190,671	0	$4,749,614	+115.3%	0.64%
DERM	Journey Medical Corp Healthcare	Reduced	960,000	-15,000	$4,502,400	−40.1%	0.61%
VYGR	Voyager Therapeutics, Inc. Healthcare	Reduced	1,150,000	-46,904	$4,439,000	−5.6%	0.60%
TRVI	Trevi Therapeutics, Inc. Healthcare	Held	345,100	0	$4,117,043	−4.7%	0.55%
TECX	Tectonic Therapeutic, Inc. Healthcare	Reduced	123,000	-91,747	$3,801,930	−15.1%	0.51%
CABA	Cabaletta Bio, Inc. Healthcare	Added	1,380,000	+480,000	$3,712,200	+88.3%	0.50%
BDSX	Biodesix Inc Healthcare	NEW	238,047	NEW	$3,451,681	NEW	0.46%
RCKT	Rocket Pharmaceuticals, Inc. Healthcare	Held	955,000	0	$3,418,900	+2.0%	0.46%
ZNTL	Zentalis Pharmaceuticals, Inc. Healthcare	Added	1,412,656	+11,750	$3,305,615	+74.8%	0.44%
NTLA	Intellia Therapeutics, Inc. Healthcare	NEW	245,000	NEW	$3,140,900	NEW	0.42%
FBIO	Fortress Biotech, Inc. Healthcare	Reduced	1,042,000	-48,000	$2,907,180	−27.1%	0.39%
RIGL	Rigel Pharmaceuticals Inc Healthcare	Held	70,000	0	$1,892,800	−36.9%	0.25%
AVIR	Atea Pharmaceuticals, Inc. Healthcare	Added	322,600	+142,785	$1,735,588	+170.4%	0.23%
LYEL	Lyell Immunopharma, Inc. Healthcare	NEW	79,097	NEW	$1,586,685	NEW	0.21%
ENTA	Enanta Pharmaceuticals Inc Healthcare	Added	125,000	+50,000	$1,578,750	+33.5%	0.21%
NXTC	NextCure, Inc. Healthcare	NEW	141,181	NEW	$1,507,813	NEW	0.20%
FDMT	4D Molecular Therapeutics, Inc. Healthcare	NEW	112,291	NEW	$1,045,429	NEW	0.14%
PLX	Protalix BioTherapeutics, Inc. Healthcare	Reduced	340,000	-2,138,176	$737,800	−83.5%	0.10%