DAFNA Capital Management LLC

CIK

1389933

Location

LOS ANGELES, CA

Portfolio Value

Small $382,680,155

Diversification

Diversified

Filing Date

Global Rank

#3,036 / 8,586 ▲ 119

Top Industry

Biotechnology 69.8%

3Y Alpha vs SPY

+2.6%

Period ended 3 months ago

Filed May 15, 2026 · 32d

25 quarters · since Mar 2020

Clone Performance

Jun 2023–Jun 2026 · vs SPY

Hypothetical growth of cloning every reported 13F position and rebalancing on each filing, indexed to the same start.

Cloned portfolio

+89.8%

SPY

+78.1%

Annualised alpha

+2.6%

Max drawdown

−42.7%

Estimate. 13F holdings are quarter-lagged and long-only, so the clone rebalances about 45 days after each period end — when the filing becomes public — and excludes options and short positions. Past performance does not predict future results.

Portfolio Concentration

79 positions · as of Mar 31, 2026 · Δ vs Dec 31, 2025

Top Position

14.8%

+1.7 pts

Top 5

35.4%

−3.8 pts

Top 10

52.1%

−3.3 pts

HHI

444

Diversified−9

Portfolio Trend

25 quarters · across all stocks

Sector Breakdown

As of Mar 31, 2026

Sector	% Portfolio	Value	Positions
Healthcare	100.0%	$382,680,155	79

Last Quarter's Activity

Export CSV

Mar 31, 2026 vs Dec 31, 2025

Added To

Positions the filer increased

20 positions

Ticker	Company	Δ Shares	Shares	Value
CMPS	COMPASS Pathways plc	+1,607,836	2,418,882	$13,376,417
LRMR	Larimar Therapeutics, Inc.	+1,090,000	2,029,164	$9,131,238
ARAY	Accuray Inc	+285,000	1,680,508	$655,398
BCAX	Bicara Therapeutics Inc.	+160,150	421,733	$8,388,269
NKTR	Nektar Therapeutics	+90,180	165,178	$11,884,557
RARE	Ultragenyx Pharmaceutical Inc.	+45,100	61,100	$1,280,045
HELP	Cybin Inc.	+43,343	498,361	$2,392,132
LXEO	Lexeo Therapeutics, Inc.	+36,200	377,059	$2,164,318
NGNE	Neurogene Inc.	+28,661	56,635	$1,141,761
MPLT	MapLight Therapeutics, Inc.	+27,242	171,006	$3,476,551
ENGN	enGene Therapeutics Inc.	+23,708	187,353	$1,275,873
STOK	Stoke Therapeutics, Inc.	+22,000	130,875	$4,261,290
INGN	Inogen Inc	+18,108	845,179	$5,223,206
RCUS	Arcus Biosciences, Inc.	+12,500	443,829	$9,586,706
BCRX	Biocryst Pharmaceuticals Inc	+11,993	430,248	$4,095,960
MBX	MBX Biosciences, Inc.	+10,200	175,465	$5,237,630
INSP	Inspire Medical Systems, Inc.	+9,600	18,200	$938,756
GPCR	Structure Therapeutics Inc.	+9,500	46,500	$2,241,300
ALKS	Alkermes plc.	+9,234	139,482	$4,932,083
PODD	Insulet Corp	+4,000	10,870	$2,280,960
No positions match the current search.

Trimmed

Positions the filer reduced

25 positions

Ticker	Company	Δ Shares	Shares	Value
IPSC	Century Therapeutics, Inc.	−359,233	2,434,353	$5,501,637
AXGN	Axogen, Inc.	−226,866	249,960	$8,281,174
ANNX	Annexon, Inc.	−155,000	117,812	$652,678
CYTK	Cytokinetics Inc	−153,500	217,497	$14,335,227
BHVN	Biohaven Ltd.	−109,500	845,735	$7,154,918
KALV	KalVista Pharmaceuticals, Inc.	−89,400	267,402	$5,382,802
SNDX	Syndax Pharmaceuticals Inc	−60,500	217,355	$5,077,412
SPRY	ARS Pharmaceuticals, Inc.	−50,780	139,285	$1,118,458
EWTX	Edgewise Therapeutics, Inc.	−47,500	112,236	$3,535,434
ORIC	Oric Pharmaceuticals, Inc.	−42,321	98,724	$1,250,833
XENE	Xenon Pharmaceuticals Inc.	−37,167	250,772	$14,582,391
IMTX	Immatics N.V.	−35,278	225,860	$2,222,462
IDYA	IDEAYA Biosciences, Inc.	−30,000	476,740	$15,884,976
RVMD	Revolution Medicines, Inc.	−23,836	580,678	$56,470,935
PROF	Profound Medical Corp.	−22,705	263,005	$1,704,272
DAWN	Day One Biopharmaceuticals, Inc.	−20,700	978,463	$20,978,246
VRCA	Verrica Pharmaceuticals Inc.	−19,739	153,712	$813,136
MDWD	MediWound Ltd.	−19,207	94,405	$1,520,864
FHTX	Foghorn Therapeutics Inc.	−15,000	111,859	$534,686
CGEN	Compugen Ltd	−14,619	257,783	$549,077
ALLO	Allogene Therapeutics, Inc.	−10,000	1,370,118	$3,343,087
AQST	Aquestive Therapeutics, Inc.	−7,500	368,415	$1,528,922
KPTI	Karyopharm Therapeutics Inc.	−5,200	45,800	$255,106
ASND	Ascendis Pharma A/S	−5,000	23,177	$5,301,275
ADCT	ADC Therapeutics SA	−5,000	72,081	$270,303
No positions match the current search.

New Positions

Positions the filer opened this quarter

9 positions

Ticker	Company	Shares	Value
FULC	Fulcrum Therapeutics, Inc.	205,000	$1,572,350
KIDS	Orthopediatrics Corp	95,659	$1,518,108
CTMX	CytomX Therapeutics, Inc.	230,000	$1,081,000
MAZE	Maze Therapeutics, Inc.	35,000	$1,044,750
SCYX	Scynexis Inc	1,086,956	$996,738
ZBIO	Zenas BioPharma, Inc.	42,500	$830,875
NAMS	NewAmsterdam Pharma Co N.V.	20,000	$640,200
PLRX	Pliant Therapeutics, Inc.	487,000	$613,620
IBIO	iBio, Inc.	193,638	$367,912
No positions match the current search.

Sold Out

Positions the filer fully exited

3 positions

Ticker	Company	Shares	Value
ERAS	Erasca, Inc.	254,436	$946,501
CATX	Perspective Therapeutics, Inc.	50,000	$137,500
BWAY	Brainsway Ltd.	12,965	$123,297
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

79 positions · $382,680,155 total · as of Mar 31, 2026

All sectors Healthcare

Showing 1–50 of 79 positions by value · page 1 of 2

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	% of Portfolio
AUTL	Autolus Therapeutics plc Healthcare	Held	179,316	0	$247,456	−30.7%	0.06%
KPTI	Karyopharm Therapeutics Inc. Healthcare	Reduced	45,800	-5,200	$255,106	−32.0%	0.07%
ADCT	ADC Therapeutics SA Healthcare	Reduced	72,081	-5,000	$270,303	−0.7%	0.07%
BCYC	Bicycle Therapeutics PLC Healthcare	Held	64,492	0	$299,242	−34.5%	0.08%
IBIO	iBio, Inc. Healthcare	NEW	193,638	NEW	$367,912	NEW	0.10%
FHTX	Foghorn Therapeutics Inc. Healthcare	Reduced	111,859	-15,000	$534,686	−21.9%	0.14%
OBIO	Orchestra BioMed Holdings, Inc. Healthcare	Held	126,841	0	$539,074	+2.4%	0.14%
CGEN	Compugen Ltd Healthcare	Reduced	257,783	-14,619	$549,077	+31.7%	0.14%
PLRX	Pliant Therapeutics, Inc. Healthcare	NEW	487,000	NEW	$613,620	NEW	0.16%
BNTX	BioNTech SE Healthcare	Held	7,000	0	$622,160	−6.6%	0.16%
ACET	Adicet Bio, Inc. Healthcare	Held	93,812	0	$638,859	−19.1%	0.17%
NAMS	NewAmsterdam Pharma Co N.V. Healthcare	NEW	20,000	NEW	$640,200	NEW	0.17%
ANNX	Annexon, Inc. Healthcare	Reduced	117,812	-155,000	$652,678	−52.3%	0.17%
ARAY	Accuray Inc Healthcare	Added	1,680,508	+285,000	$655,398	−42.7%	0.17%
FATE	Fate Therapeutics Inc Healthcare	Held	550,000	0	$660,000	+22.4%	0.17%
VRCA	Verrica Pharmaceuticals Inc. Healthcare	Reduced	153,712	-19,739	$813,136	−43.6%	0.21%
ZBIO	Zenas BioPharma, Inc. Healthcare	NEW	42,500	NEW	$830,875	NEW	0.22%
TELA	TELA Bio, Inc. Healthcare	Held	1,441,029	0	$893,437	−47.5%	0.23%
PYPD	PolyPid Ltd. Healthcare	Held	207,900	0	$910,602	+0.9%	0.24%
INSP	Inspire Medical Systems, Inc. Healthcare	Added	18,200	+9,600	$938,756	+18.4%	0.25%
SCYX	Scynexis Inc Healthcare	NEW	1,086,956	NEW	$996,738	NEW	0.26%
MLYS	Mineralys Therapeutics, Inc. Healthcare	Held	38,490	0	$1,042,694	−25.4%	0.27%
MAZE	Maze Therapeutics, Inc. Healthcare	NEW	35,000	NEW	$1,044,750	NEW	0.27%
CTMX	CytomX Therapeutics, Inc. Healthcare	NEW	230,000	NEW	$1,081,000	NEW	0.28%
SPRY	ARS Pharmaceuticals, Inc. Healthcare	Reduced	139,285	-50,780	$1,118,458	−49.5%	0.29%
NGNE	Neurogene Inc. Healthcare	Added	56,635	+28,661	$1,141,761	+98.1%	0.30%
ORIC	Oric Pharmaceuticals, Inc. Healthcare	Reduced	98,724	-42,321	$1,250,833	+8.4%	0.33%
ENGN	enGene Therapeutics Inc. Healthcare	Added	187,353	+23,708	$1,275,873	−13.7%	0.33%
RARE	Ultragenyx Pharmaceutical Inc. Healthcare	Added	61,100	+45,100	$1,280,045	+247.8%	0.33%
KIDS	Orthopediatrics Corp Healthcare	NEW	95,659	NEW	$1,518,108	NEW	0.40%
MDWD	MediWound Ltd. Healthcare	Reduced	94,405	-19,207	$1,520,864	−27.5%	0.40%
AQST	Aquestive Therapeutics, Inc. Healthcare	Reduced	368,415	-7,500	$1,528,922	−37.0%	0.40%
FULC	Fulcrum Therapeutics, Inc. Healthcare	NEW	205,000	NEW	$1,572,350	NEW	0.41%
PROF	Profound Medical Corp. Healthcare	Reduced	263,005	-22,705	$1,704,272	−24.2%	0.45%
KURA	Kura Oncology, Inc. Healthcare	Held	235,868	0	$1,917,606	−21.8%	0.50%
VKTX	Viking Therapeutics, Inc. Healthcare	Held	59,516	0	$1,936,650	−7.5%	0.51%
ALEC	Alector, Inc. Healthcare	Held	908,351	0	$1,952,954	+37.8%	0.51%
LXEO	Lexeo Therapeutics, Inc. Healthcare	Added	377,059	+36,200	$2,164,318	−36.1%	0.57%
CLDX	Celldex Therapeutics, Inc. Healthcare	Held	68,518	0	$2,173,390	+16.8%	0.57%
IMTX	Immatics N.V. Healthcare	Reduced	225,860	-35,278	$2,222,462	−18.9%	0.58%
GPCR	Structure Therapeutics Inc. Healthcare	Added	46,500	+9,500	$2,241,300	−12.9%	0.59%
PODD	Insulet Corp Healthcare	Added	10,870	+4,000	$2,280,960	+16.8%	0.60%
RAPP	Rapport Therapeutics, Inc. Healthcare	Held	75,000	0	$2,346,750	+3.1%	0.61%
HELP	Cybin Inc. Healthcare	Added	498,361	+43,343	$2,392,132	−35.7%	0.63%
PRQR	ProQR Therapeutics N.V. Healthcare	Held	1,567,561	0	$2,539,448	−19.8%	0.66%
ALGN	Align Technology Inc Healthcare	Reduced	15,000	-1,000	$2,571,450	+2.9%	0.67%
PRCT	PROCEPT BioRobotics Corp Healthcare	Held	120,000	0	$3,001,200	−20.5%	0.78%
ALLO	Allogene Therapeutics, Inc. Healthcare	Reduced	1,370,118	-10,000	$3,343,087	+76.8%	0.87%
MPLT	MapLight Therapeutics, Inc. Healthcare	Added	171,006	+27,242	$3,476,551	+37.7%	0.91%
EWTX	Edgewise Therapeutics, Inc. Healthcare	Reduced	112,236	-47,500	$3,535,434	−10.8%	0.92%