Sofinnova Investments, Inc.

CIK

1631134

Location

Menlo Park, CA

Portfolio Value

Mid $1,933,731,887

Diversification

Diversified

Filing Date

Global Rank

#1,353 / 8,700 ▼ 109

Top Industry

Biotechnology 62.7%

Period ended 2 months ago

Filed Aug 14, 2026 · 30d

26 quarters · since Mar 2020

Portfolio Concentration

55 tracked positions · as of Jun 30, 2026 · Δ vs Mar 31, 2026

Top Position

21.8%

+10.0 pts

Top 5

42.4%

+9.8 pts

Top 10

58.8%

+7.8 pts

HHI

703

Diversified+306

Portfolio Trend

26 quarters · across all stocks

Sector Breakdown

As of Jun 30, 2026

Sector	% Portfolio	Value	Positions
Healthcare	100.0%	$1,933,731,887	55

Last Quarter's Activity

Export CSV

Jun 30, 2026 vs Mar 31, 2026

Added To

Positions the filer increased

13 positions

Ticker	Company	Δ Shares	Shares	Value
GMAB	Genmab A/S	+3,292,954	4,045,215	$111,122,056
TENX	Tenax Therapeutics, Inc.	+395,639	500,039	$7,275,567
ANAB	Anaptysbio, Inc	+245,283	493,536	$33,313,680
OKUR	OnKure Therapeutics, Inc.	+179,992	321,692	$1,466,915
SUPN	Supernus Pharmaceuticals, Inc.	+82,019	1,036,328	$48,199,615
MANE	Veradermics, Inc	+75,678	148,993	$18,317,199
IRON	Disc Medicine, Inc.	+67,919	146,239	$10,695,920
PHVS	Pharvaris N.V.	+62,971	881,299	$30,475,319
IMTX	Immatics N.V.	+38,892	3,669,346	$37,170,474
DYN	Dyne Therapeutics, Inc.	+24,487	1,658,384	$36,832,708
RCUS	Arcus Biosciences, Inc.	+22,604	945,690	$29,155,622
IMNM	Immunome Inc.	+18,412	1,720,316	$36,453,496
EXEL	Exelixis, Inc.	+2,700	254,200	$13,831,022
No positions match the current search.

Trimmed

Positions the filer reduced

17 positions

Ticker	Company	Δ Shares	Shares	Value
RARE	Ultragenyx Pharmaceutical Inc.	−1,278,383	2,217,505	$74,042,491
BMY	Bristol Myers Squibb Co	−1,111,751	876,970	$50,531,011
COGT	Cogent Biosciences, Inc.	−1,078,403	1,035,148	$40,060,227
ALC	Alcon Inc	−474,148	255,824	$17,165,790
BMRN	Biomarin Pharmaceutical Inc	−423,414	358,568	$20,517,260
AXSM	Axsome Therapeutics, Inc.	−252,318	160,429	$39,268,206
JAZZ	Jazz Pharmaceuticals plc	−232,986	365,341	$88,036,220
IDYA	IDEAYA Biosciences, Inc.	−206,667	925,119	$34,479,185
INSM	INSMED Inc	−187,677	158,398	$16,888,394
TYRA	Tyra Biosciences, Inc.	−171,748	32,267	$1,030,607
UTHR	UNITED THERAPEUTICS Corp	−163,881	76,489	$41,444,034
INBX	Inhibrx Biosciences, Inc.	−102,926	303,103	$28,719,009
DFTX	Definium Therapeutics, Inc.	−88,263	255,903	$12,037,677
PRAX	Praxis Precision Medicines, Inc.	−57,240	6,440	$2,156,047
RYTM	Rhythm Pharmaceuticals, Inc.	−42,069	408,027	$45,303,237
NKTR	Nektar Therapeutics	−37,783	471,763	$32,933,775
EWTX	Edgewise Therapeutics, Inc.	−5,575	380,923	$15,476,901
No positions match the current search.

New Positions

Positions the filer opened this quarter

13 positions

Ticker	Company	Shares	Value
SPTX	Seaport Therapeutics, Inc.	3,564,871	$77,428,998
GILD	Gilead Sciences, Inc.	343,100	$43,347,254
ISRG	Intuitive Surgical Inc	40,000	$15,907,200
GMED	Globus Medical Inc	200,000	$15,802,000
NRIX	Nurix Therapeutics, Inc.	524,098	$12,714,617
DSGN	Design Therapeutics, Inc.	865,135	$12,518,503
TRAX	First Tracks Biotherapeutics, Inc.	565,199	$11,371,803
ABT	Abbott Laboratories	122,998	$11,160,838
SION	Sionna Therapeutics, Inc.	144,432	$6,353,563
ABSI	Absci Corp	337,400	$3,910,466
SGMT	Sagimet Biosciences Inc.	166,667	$1,288,335
AKTS	Aktis Oncology, Inc.	32,436	$1,045,412
HTFL	Heartflow, Inc.	5,079	$149,017
No positions match the current search.

Sold Out

Positions the filer fully exited

25 positions

Ticker	Company	Shares	Value
AAXJ	iShares MSCI All Country Asia ex Japan ETF	600,000	$148,800,000
BWX	State Street SPDR Bloomberg International Treasury Bond ETF	1,050,000	$134,116,500
AZN	Astrazeneca PLC	456,031	$89,938,433
QQQ	Invesco Qqq Trust, Series 1	150,000	$86,577,000
—		475,000	$80,203,750
CELC	Celcuity Inc.	666,175	$76,037,214
BIIB	Biogen Inc.	229,521	$42,078,084
BBIO	BridgeBio Pharma, Inc.	409,183	$30,385,929
DXCM	Dexcom Inc	393,576	$24,716,572
PFE	Pfizer Inc	800,000	$22,464,000
LQDA	Liquidia Corp	500,000	$18,870,000
XENE	Xenon Pharmaceuticals Inc.	305,216	$17,748,310
SYK	Stryker Corp	44,480	$14,615,683
CMPX	Compass Therapeutics, Inc.	2,556,161	$13,522,091
ROIV	Roivant Sciences Ltd.	477,995	$13,240,461
ORIC	Oric Pharmaceuticals, Inc.	679,578	$8,610,253
TNGX	Tango Therapeutics, Inc.	395,081	$8,265,094
REPL	Replimune Group, Inc.	1,015,400	$7,767,810
AXGN	Axogen, Inc.	210,665	$6,979,331
CYTK	Cytokinetics Inc	91,791	$6,049,944
HRMY	Harmony Biosciences Holdings, Inc.	152,695	$4,276,986
PCVX	Vaxcyte, Inc.	50,600	$2,940,366
ESTA	Establishment Labs Holdings Inc.	33,930	$1,926,545
ACAD	Acadia Pharmaceuticals Inc	78,551	$1,748,545
ZYME	Zymeworks Inc.	1,610	$40,314
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

55 tracked positions · $1,933,731,887 total · filing declares 57 positions · $1,934,262,135 · as of Jun 30, 2026

All sectors Healthcare

Showing 1–50 of 55 positions by value · page 1 of 2

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	% of Portfolio
NTRA	Natera, Inc. Healthcare	Held	1,550,280	0	$420,823,506	+35.7%	21.76%
VERA	Vera Therapeutics, Inc. Healthcare	Held	2,793,987	0	$119,889,982	+6.7%	6.20%
GMAB	Genmab A/S Healthcare	Added	4,045,215	+3,292,954	$111,122,056	+450.6%	5.75%
JAZZ	Jazz Pharmaceuticals plc Healthcare	Reduced	365,341	-232,986	$88,036,220	−22.2%	4.55%
RAPP	Rapport Therapeutics, Inc. Healthcare	Held	1,904,408	0	$79,356,681	+33.2%	4.10%
SPTX	Seaport Therapeutics, Inc. Healthcare	NEW	3,564,871	NEW	$77,428,998	NEW	4.00%
RARE	Ultragenyx Pharmaceutical Inc. CALL + SHARES Healthcare	Reduced	2,217,505	-1,278,383	$74,042,491	+1.1%	3.83%
AVBP	ArriVent BioPharma, Inc. Healthcare	Held	1,696,752	0	$58,945,164	+50.6%	3.05%
BIOA	BioAge Labs, Inc. Healthcare	Held	2,293,788	0	$56,220,743	+40.1%	2.91%
BMY	Bristol Myers Squibb Co Healthcare	Reduced	876,970	-1,111,751	$50,531,011	−58.1%	2.61%
SUPN	Supernus Pharmaceuticals, Inc. Healthcare	Added	1,036,328	+82,019	$48,199,615	−2.3%	2.49%
RYTM	Rhythm Pharmaceuticals, Inc. Healthcare	Reduced	408,027	-42,069	$45,303,237	+15.7%	2.34%
GILD	Gilead Sciences, Inc. Healthcare	NEW	343,100	NEW	$43,347,254	NEW	2.24%
UTHR	UNITED THERAPEUTICS Corp Healthcare	Reduced	76,489	-163,881	$41,444,034	−70.9%	2.14%
COGT	Cogent Biosciences, Inc. Healthcare	Reduced	1,035,148	-1,078,403	$40,060,227	−50.8%	2.07%
AXSM	Axsome Therapeutics, Inc. Healthcare	Reduced	160,429	-252,318	$39,268,206	−43.7%	2.03%
IMTX	Immatics N.V. Healthcare	Added	3,669,346	+38,892	$37,170,474	+4.0%	1.92%
DYN	Dyne Therapeutics, Inc. Healthcare	Added	1,658,384	+24,487	$36,832,708	+24.3%	1.90%
IMNM	Immunome Inc. Healthcare	Added	1,720,316	+18,412	$36,453,496	−2.1%	1.89%
IDYA	IDEAYA Biosciences, Inc. Healthcare	Reduced	925,119	-206,667	$34,479,185	−8.6%	1.78%
ANAB	Anaptysbio, Inc Healthcare	Added	493,536	+245,283	$33,313,680	+142.0%	1.72%
NKTR	Nektar Therapeutics Healthcare	Reduced	471,763	-37,783	$32,933,775	−10.2%	1.70%
PHVS	Pharvaris N.V. Healthcare	Added	881,299	+62,971	$30,475,319	+31.8%	1.58%
RCUS	Arcus Biosciences, Inc. Healthcare	Added	945,690	+22,604	$29,155,622	+46.2%	1.51%
INBX	Inhibrx Biosciences, Inc. Healthcare	Reduced	303,103	-102,926	$28,719,009	+5.2%	1.49%
BMRN	Biomarin Pharmaceutical Inc Healthcare	Reduced	358,568	-423,414	$20,517,260	−53.6%	1.06%
MANE	Veradermics, Inc Healthcare	Added	148,993	+75,678	$18,317,199	+295.6%	0.95%
ALC	Alcon Inc Healthcare	Reduced	255,824	-474,148	$17,165,790	−68.8%	0.89%
INSM	INSMED Inc Healthcare	Reduced	158,398	-187,677	$16,888,394	−70.2%	0.87%
ISRG	Intuitive Surgical Inc CALL Healthcare	NEW	40,000	NEW	$15,907,200	NEW	0.82%
GMED	Globus Medical Inc CALL Healthcare	NEW	200,000	NEW	$15,802,000	NEW	0.82%
EWTX	Edgewise Therapeutics, Inc. Healthcare	Reduced	380,923	-5,575	$15,476,901	+27.1%	0.80%
EXEL	Exelixis, Inc. PUT Healthcare	Added	254,200	+2,700	$13,831,022	+28.2%	0.72%
NRIX	Nurix Therapeutics, Inc. Healthcare	NEW	524,098	NEW	$12,714,617	NEW	0.66%
DSGN	Design Therapeutics, Inc. Healthcare	NEW	865,135	NEW	$12,518,503	NEW	0.65%
DFTX	Definium Therapeutics, Inc. Healthcare	Reduced	255,903	-88,263	$12,037,677	+85.1%	0.62%
TRAX	First Tracks Biotherapeutics, Inc. Healthcare	NEW	565,199	NEW	$11,371,803	NEW	0.59%
ABT	Abbott Laboratories Healthcare	NEW	122,998	NEW	$11,160,838	NEW	0.58%
IRON	Disc Medicine, Inc. Healthcare	Added	146,239	+67,919	$10,695,920	+113.6%	0.55%
TENX	Tenax Therapeutics, Inc. Healthcare	Added	500,039	+395,639	$7,275,567	+335.8%	0.38%
SION	Sionna Therapeutics, Inc. Healthcare	NEW	144,432	NEW	$6,353,563	NEW	0.33%
ABSI	Absci Corp Healthcare	NEW	337,400	NEW	$3,910,466	NEW	0.20%
MIRM	Mirum Pharmaceuticals, Inc. Healthcare	Held	27,591	0	$3,230,078	+26.7%	0.17%
JBIO	Jade Biosciences, Inc. Healthcare	Held	107,391	0	$2,386,228	+58.1%	0.12%
SVRA	Savara Inc Healthcare	Held	364,763	0	$2,246,940	+12.8%	0.12%
PRAX	Praxis Precision Medicines, Inc. Healthcare	Reduced	6,440	-57,240	$2,156,047	−89.5%	0.11%
SEPN	Septerna, Inc. Healthcare	Held	47,506	0	$1,590,975	+39.4%	0.08%
OKUR	OnKure Therapeutics, Inc. Healthcare	Added	321,692	+179,992	$1,466,915	+150.1%	0.08%
SGMT	Sagimet Biosciences Inc. Healthcare	NEW	166,667	NEW	$1,288,335	NEW	0.07%
WVE	Wave Life Sciences, Inc. Healthcare	Held	189,253	0	$1,099,559	−19.9%	0.06%

Covers the securities this platform tracks: U.S.-listed common stock and the put/call positions reported on it. A 13F can also report security types outside that coverage — preferred shares, bonds, warrants, untracked share classes — so the filing's own declared total can exceed the figures above. The source filing is linked at the top of this table.