Sofinnova Investments, Inc.
Filing Date
Global Rank
#1,120
/ 8,623
▲ 68
· as of Mar 2026
Top Industry
Biotechnology
56.9%
3Y Alpha vs SPY
+9.0%
Period ended 4 months ago
Filed May 15, 2026 · 3mo
25 quarters · since Mar 2020
Clone Performance
Jul 2023–Jul 2026 · vs SPYHypothetical growth of buying every stock this filer reported holding, rebalancing on each filing and indexed to the same start. Option positions cannot be bought this way and are left out.
Cloned portfolio
+108.3%
SPY
+67.9%
Annualised alpha
+8.9%
Max drawdown
−37.0%
Estimate. 13F holdings are quarter-lagged, so the clone rebalances about 45 days after each period end — when the filing becomes public — and it excludes option and short positions. It tracks 94% of reported value on average across 13 quarters. Past performance does not predict future results.
Portfolio Concentration
65 tracked positions · as of Mar 31, 2026 · Δ vs Dec 31, 2025Top Position
13.7%
−3.4 pts
Top 5
35.2%
−4.2 pts
Top 10
53.2%
−3.4 pts
HHI
444
Diversified−113
Portfolio Trend
25 quarters · across all stocks
Sector Breakdown
As of Mar 31, 2026| Sector | % Portfolio | Value |
|---|---|---|
| Healthcare | 96.2% | $2,180,900,529 |
| Unclassified | 3.8% | $86,577,000 |
Last Quarter's Activity
Export CSVAdded To
Positions the filer increased
24 positions
| Ticker | Company | Δ Shares | Shares | Value | Open |
|---|---|---|---|---|---|
| RARE | Ultragenyx Pharmaceutical Inc. | +3,412,588 | 3,495,888 | $73,238,853 | |
| BMY | Bristol Myers Squibb Co | +475,727 | 1,988,721 | $120,615,928 | |
| SUPN | Supernus Pharmaceuticals, Inc. | +401,214 | 954,309 | $49,328,232 | |
| AXSM | Axsome Therapeutics, Inc. | +400,481 | 412,747 | $69,762,497 | |
| ALC | Alcon Inc | +397,452 | 729,972 | $55,003,390 | |
| CELC | Celcuity Inc. | +366,758 | 666,175 | $76,037,214 | |
| IDYA | IDEAYA Biosciences, Inc. | +246,665 | 1,131,786 | $37,711,109 | |
| XENE | Xenon Pharmaceuticals Inc. | +245,316 | 305,216 | $17,748,310 | |
| IMTX | Immatics N.V. | +194,912 | 3,630,454 | $35,723,667 | |
| INSM | INSMED Inc | +189,274 | 346,075 | $56,590,184 | |
| RYTM | Rhythm Pharmaceuticals, Inc. | +178,702 | 450,096 | $39,144,849 | |
| COGT | Cogent Biosciences, Inc. | +139,926 | 2,113,551 | $81,350,577 | |
| BMRN | Biomarin Pharmaceutical Inc | +84,849 | 781,982 | $44,174,163 | |
| IMNM | Immunome Inc. | +83,427 | 1,701,904 | $37,220,640 | |
| UTHR | UNITED THERAPEUTICS Corp | +82,729 | 240,370 | $142,534,602 | |
| PHVS | Pharvaris N.V. | +73,159 | 818,328 | $23,117,766 | |
| NKTR | Nektar Therapeutics | +70,916 | 509,546 | $36,661,834 | |
| SVRA | Savara Inc | +59,993 | 364,763 | $1,991,605 | |
| WVE | Wave Life Sciences Ltd. | +31,071 | 189,253 | $1,372,084 | |
| DXCM | Dexcom Inc | +15,357 | 393,576 | $24,716,572 | |
| ACAD | Acadia Pharmaceuticals Inc | +12,984 | 78,551 | $1,748,545 | |
| ESTA | Establishment Labs Holdings Inc. | +5,564 | 33,930 | $1,926,545 | |
| MIRM | Mirum Pharmaceuticals, Inc. | +4,491 | 27,591 | $2,548,856 | |
| SLNO | Soleno Therapeutics Inc | +2,275 | 14,689 | $491,787 | |
| No positions match the current search. | |||||
Trimmed
Positions the filer reduced
11 positions
| Ticker | Company | Δ Shares | Shares | Value | Open |
|---|---|---|---|---|---|
| CMPX | Compass Therapeutics, Inc. | −809,285 | 2,556,161 | $13,522,091 | |
| DYN | Dyne Therapeutics, Inc. | −620,264 | 1,633,897 | $29,622,552 | |
| JAZZ | Jazz Pharmaceuticals plc | −361,533 | 598,327 | $113,113,719 | |
| BBIO | BridgeBio Pharma, Inc. | −311,265 | 409,183 | $30,385,929 | |
| ROIV | Roivant Sciences Ltd. | −256,587 | 477,995 | $13,240,461 | |
| RCUS | Arcus Biosciences, Inc. | −173,619 | 923,086 | $19,938,657 | |
| PRAX | Praxis Precision Medicines, Inc. | −62,042 | 63,680 | $20,517,059 | |
| EWTX | Edgewise Therapeutics, Inc. | −51,321 | 386,498 | $12,174,687 | |
| INBX | Inhibrx Biosciences, Inc. | −48,628 | 406,029 | $27,297,329 | |
| ANAB | Anaptysbio, Inc | −39,437 | 248,253 | $13,768,098 | |
| IRON | Disc Medicine, Inc. | −32,690 | 78,320 | $5,007,780 | |
| No positions match the current search. | |||||
New Positions
Positions the filer opened this quarter
22 positions
| Ticker | Company | Shares | Value | Open |
|---|---|---|---|---|
| AZN | Astrazeneca PLC | 456,031 | $89,938,433 | |
| QQQ | Invesco Qqq Trust, Series 1 | 150,000 | $86,577,000 | |
| BIIB | Biogen Inc. | 229,521 | $42,078,084 | |
| PFE | Pfizer Inc | 800,000 | $22,464,000 | |
| GMAB | Genmab A/S | 752,261 | $20,183,162 | |
| LQDA | Liquidia Corp | 500,000 | $18,870,000 | |
| SYK | Stryker Corp | 44,480 | $14,615,683 | |
| EXEL | Exelixis, Inc. | 251,500 | $10,786,835 | |
| ORIC | Oric Pharmaceuticals, Inc. | 679,578 | $8,610,253 | |
| TNGX | Tango Therapeutics, Inc. | 395,081 | $8,265,094 | |
| TYRA | Tyra Biosciences, Inc. | 204,015 | $7,813,774 | |
| REPL | Replimune Group, Inc. | 1,015,400 | $7,767,810 | |
| AXGN | Axogen, Inc. | 210,665 | $6,979,331 | |
| DFTX | Definium Therapeutics, Inc. | 344,166 | $6,504,737 | |
| CYTK | Cytokinetics Inc | 91,791 | $6,049,944 | |
| MANE | Veradermics, Inc | 73,315 | $4,629,842 | |
| HRMY | Harmony Biosciences Holdings, Inc. | 152,695 | $4,276,986 | |
| PCVX | Vaxcyte, Inc. | 50,600 | $2,940,366 | |
| TENX | Tenax Therapeutics, Inc. | 104,400 | $1,669,356 | |
| SEPN | Septerna, Inc. | 47,506 | $1,141,569 | |
| OKUR | OnKure Therapeutics, Inc. | 141,700 | $586,638 | |
| ZYME | Zymeworks Inc. | 1,610 | $40,314 | |
| No positions match the current search. | ||||
Sold Out
Positions the filer fully exited
13 positions
| Ticker | Company | Shares | Value | Open |
|---|---|---|---|---|
| VRTX | Vertex Pharmaceuticals Inc / Ma | 164,594 | $74,620,335 | |
| ABBV | AbbVie Inc. | 317,783 | $72,610,237 | |
| ISRG | Intuitive Surgical Inc | 126,968 | $71,909,596 | |
| LLY | ELI LILLY & Co | 61,652 | $66,256,177 | |
| APGE | Apogee Therapeutics, Inc. | 534,845 | $40,370,100 | |
| GKOS | GLAUKOS Corp | 288,128 | $32,532,532 | |
| CNTA | Centessa Pharmaceuticals plc | 1,104,274 | $27,617,892 | |
| GEHC | GE HealthCare Technologies Inc. | 160,876 | $13,195,049 | |
| EXAS | EXACT SCIENCES CORP | 101,443 | $10,302,551 | |
| AMLX | Amylyx Pharmaceuticals, Inc. | 527,099 | $6,367,355 | |
| MASI | Masimo Corp | 46,201 | $6,008,902 | |
| QURE | uniQure N.V. | 176,513 | $4,223,956 | |
| EVMN | Evommune, Inc. | 153,320 | $2,624,838 | |
| No positions match the current search. | ||||
65 tracked positions ·
$2,267,477,529 total
· filing declares
75 positions · $2,631,154,214
· as of Mar 31, 2026
Showing 1–50
of 65 positions by value
· page 1 of 2
| Ticker | Company | Type | Shares | Value (USD) | % of Portfolio | History |
|---|---|---|---|---|---|---|
| NTRA |
Natera, Inc.
Healthcare
|
Held | 1,550,280 | $310,040,497 | 13.67% | |
| UTHR |
UNITED THERAPEUTICS Corp
PUT
+ SHARES
Healthcare
|
Added | 240,370 | $142,534,602 | 6.29% | |
| BMY |
Bristol Myers Squibb Co
Healthcare
|
Added | 1,988,721 | $120,615,928 | 5.32% | |
| JAZZ |
Jazz Pharmaceuticals plc
Healthcare
|
Reduced | 598,327 | $113,113,719 | 4.99% | |
| VERA |
Vera Therapeutics, Inc.
Healthcare
|
Held | 2,793,987 | $112,402,097 | 4.96% | |
| AZN |
Astrazeneca PLC
Healthcare
|
NEW | 456,031 | $89,938,433 | 3.97% | |
| QQQ |
Invesco Qqq Trust, Series 1
PUT
|
NEW | 150,000 | $86,577,000 | 3.82% | |
| COGT |
Cogent Biosciences, Inc.
Healthcare
|
Added | 2,113,551 | $81,350,577 | 3.59% | |
| CELC |
Celcuity Inc.
PUT
+ SHARES
Healthcare
|
Added | 666,175 | $76,037,214 | 3.35% | |
| RARE |
Ultragenyx Pharmaceutical Inc.
CALL
+ SHARES
Healthcare
|
Added | 3,495,888 | $73,238,853 | 3.23% | |
| AXSM |
Axsome Therapeutics, Inc.
PUT
+ SHARES
Healthcare
|
Added | 412,747 | $69,762,497 | 3.08% | |
| RAPP |
Rapport Therapeutics, Inc.
Healthcare
|
Held | 1,904,408 | $59,588,926 | 2.63% | |
| INSM |
INSMED Inc
Healthcare
|
Added | 346,075 | $56,590,184 | 2.50% | |
| ALC |
Alcon Inc
Healthcare
|
Added | 729,972 | $55,003,390 | 2.43% | |
| SUPN |
Supernus Pharmaceuticals, Inc.
Healthcare
|
Added | 954,309 | $49,328,232 | 2.18% | |
| BMRN |
Biomarin Pharmaceutical Inc
Healthcare
|
Added | 781,982 | $44,174,163 | 1.95% | |
| BIIB |
Biogen Inc.
Healthcare
|
NEW | 229,521 | $42,078,084 | 1.86% | |
| BIOA |
BioAge Labs, Inc.
Healthcare
|
Held | 2,293,788 | $40,118,352 | 1.77% | |
| RYTM |
Rhythm Pharmaceuticals, Inc.
Healthcare
|
Added | 450,096 | $39,144,849 | 1.73% | |
| AVBP |
ArriVent BioPharma, Inc.
Healthcare
|
Held | 1,696,752 | $39,144,068 | 1.73% | |
| IDYA |
IDEAYA Biosciences, Inc.
Healthcare
|
Added | 1,131,786 | $37,711,109 | 1.66% | |
| IMNM |
Immunome Inc.
Healthcare
|
Added | 1,701,904 | $37,220,640 | 1.64% | |
| NKTR |
Nektar Therapeutics
Healthcare
|
Added | 509,546 | $36,661,834 | 1.62% | |
| IMTX |
Immatics N.V.
Healthcare
|
Added | 3,630,454 | $35,723,667 | 1.58% | |
| BBIO |
BridgeBio Pharma, Inc.
Healthcare
|
Reduced | 409,183 | $30,385,929 | 1.34% | |
| DYN |
Dyne Therapeutics, Inc.
Healthcare
|
Reduced | 1,633,897 | $29,622,552 | 1.31% | |
| INBX |
Inhibrx Biosciences, Inc.
Healthcare
|
Reduced | 406,029 | $27,297,329 | 1.20% | |
| DXCM |
Dexcom Inc
Healthcare
|
Added | 393,576 | $24,716,572 | 1.09% | |
| PHVS |
Pharvaris N.V.
Healthcare
|
Added | 818,328 | $23,117,766 | 1.02% | |
| PFE |
Pfizer Inc
CALL
Healthcare
|
NEW | 800,000 | $22,464,000 | 0.99% | |
| PRAX |
Praxis Precision Medicines, Inc.
Healthcare
|
Reduced | 63,680 | $20,517,059 | 0.90% | |
| GMAB |
Genmab A/S
Healthcare
|
NEW | 752,261 | $20,183,162 | 0.89% | |
| RCUS |
Arcus Biosciences, Inc.
Healthcare
|
Reduced | 923,086 | $19,938,657 | 0.88% | |
| LQDA |
Liquidia Corp
PUT
Healthcare
|
NEW | 500,000 | $18,870,000 | 0.83% | |
| XENE |
Xenon Pharmaceuticals Inc.
Healthcare
|
Added | 305,216 | $17,748,310 | 0.78% | |
| SYK |
Stryker Corp
Healthcare
|
NEW | 44,480 | $14,615,683 | 0.64% | |
| ANAB |
Anaptysbio, Inc
Healthcare
|
Reduced | 248,253 | $13,768,098 | 0.61% | |
| CMPX |
Compass Therapeutics, Inc.
CALL
+ SHARES
Healthcare
|
Reduced | 2,556,161 | $13,522,091 | 0.60% | |
| ROIV |
Roivant Sciences Ltd.
Healthcare
|
Reduced | 477,995 | $13,240,461 | 0.58% | |
| EWTX |
Edgewise Therapeutics, Inc.
Healthcare
|
Reduced | 386,498 | $12,174,687 | 0.54% | |
| EXEL |
Exelixis, Inc.
PUT
Healthcare
|
NEW | 251,500 | $10,786,835 | 0.48% | |
| ORIC |
Oric Pharmaceuticals, Inc.
Healthcare
|
NEW | 679,578 | $8,610,253 | 0.38% | |
| TNGX |
Tango Therapeutics, Inc.
Healthcare
|
NEW | 395,081 | $8,265,094 | 0.36% | |
| TYRA |
Tyra Biosciences, Inc.
Healthcare
|
NEW | 204,015 | $7,813,774 | 0.34% | |
| REPL |
Replimune Group, Inc.
CALL
Healthcare
|
NEW | 1,015,400 | $7,767,810 | 0.34% | |
| AXGN |
Axogen, Inc.
Healthcare
|
NEW | 210,665 | $6,979,331 | 0.31% | |
| DFTX |
Definium Therapeutics, Inc.
Healthcare
|
NEW | 344,166 | $6,504,737 | 0.29% | |
| CYTK |
Cytokinetics Inc
Healthcare
|
NEW | 91,791 | $6,049,944 | 0.27% | |
| IRON |
Disc Medicine, Inc.
Healthcare
|
Reduced | 78,320 | $5,007,780 | 0.22% | |
| MANE |
Veradermics, Inc
Healthcare
|
NEW | 73,315 | $4,629,842 | 0.20% |
Covers the securities this platform tracks: U.S.-listed common stock and the put/call positions reported on it. A 13F can also report security types outside that coverage — preferred shares, bonds, warrants, untracked share classes — so the filing's own declared total can exceed the figures above. The source filing is linked at the top of this table.