Rock Springs Capital Management LP

CIK

1595725

Location

Baltimore, MD

Portfolio Value

Mid $1,692,833,901

Diversification

Diversified

Filing Date

Global Rank

#1,318 / 8,622 ▼ 40 · as of Mar 2026

Top Industry

Biotechnology 73.6%

3Y Alpha vs SPY

-31.7%

Period ended 4 months ago

Filed May 15, 2026 · 2mo

25 quarters · since Mar 2020

Clone Performance

Jul 2023–Jul 2026 · vs SPY

Hypothetical growth of buying every stock this filer reported holding, rebalancing on each filing and indexed to the same start. Option positions cannot be bought this way and are left out.

Cloned portfolio

+25.3%

SPY

+67.9%

Annualised alpha

-11.0%

Max drawdown

−29.8%

Estimate. 13F holdings are quarter-lagged, so the clone rebalances about 45 days after each period end — when the filing becomes public — and it excludes option and short positions. It tracks 100% of reported value on average across 13 quarters. Past performance does not predict future results.

Portfolio Concentration

99 tracked positions · as of Mar 31, 2026 · Δ vs Dec 31, 2025

Top Position

6.9%

+0.8 pts

Top 5

26.3%

+0.8 pts

Top 10

40.7%

−1.1 pts

HHI

257

Diversified−2

Portfolio Trend

25 quarters · across all stocks

Sector Breakdown

As of Mar 31, 2026

Sector	% Portfolio	Value	Positions
Healthcare	100.0%	$1,692,833,901	99

Last Quarter's Activity

Export CSV

Mar 31, 2026 vs Dec 31, 2025

Added To

Positions the filer increased

25 positions

Ticker	Company	Δ Shares	Shares	Value
HTFL	Heartflow, Inc.	+294,800	572,500	$13,928,925
ERAS	Erasca, Inc.	+151,759	1,103,469	$17,854,128
BSX	Boston Scientific Corp	+116,250	515,300	$32,335,075
PTCT	Ptc Therapeutics, Inc.	+99,919	161,798	$11,023,297
FOCL	Edap Tms SA	+91,500	1,378,000	$5,126,160
OLMA	Olema Pharmaceuticals, Inc.	+72,138	170,378	$2,540,335
BCAX	Bicara Therapeutics Inc.	+60,000	489,095	$9,728,099
DYN	Dyne Therapeutics, Inc.	+59,243	972,198	$17,625,949
MIRM	Mirum Pharmaceuticals, Inc.	+49,000	811,294	$74,947,339
ATEC	Alphatec Holdings, Inc.	+47,500	350,000	$3,808,000
ALKS	Alkermes plc.	+44,758	183,986	$6,505,744
OCUL	Ocular Therapeutix, Inc	+37,896	383,716	$3,250,074
MDGL	Madrigal Pharmaceuticals, Inc.	+31,381	170,999	$89,512,846
ELVN	Enliven Therapeutics, Inc.	+28,095	826,500	$32,398,800
CNTA	Centessa Pharmaceuticals plc	+27,813	351,828	$13,974,608
IRTC	iRhythm Holdings, Inc.	+26,750	261,750	$30,891,735
NBIX	Neurocrine Biosciences Inc	+24,950	150,450	$19,820,283
BBIO	BridgeBio Pharma, Inc.	+24,750	128,250	$9,523,845
PHVS	Pharvaris N.V.	+22,131	645,533	$18,236,307
ACRS	Aclaris Therapeutics, Inc.	+18,909	4,472,650	$16,772,437
PCVX	Vaxcyte, Inc.	+13,250	60,250	$3,501,127
APLS	Apellis Pharmaceuticals, Inc.	+12,250	162,750	$6,547,432
UNH	Unitedhealth Group Inc	+12,200	53,000	$14,341,270
MLYS	Mineralys Therapeutics, Inc.	+12,155	439,751	$11,912,854
SLNO	Soleno Therapeutics Inc	+10,200	257,253	$8,612,830
No positions match the current search.

Trimmed

Positions the filer reduced

24 positions

Ticker	Company	Δ Shares	Shares	Value
AGL	agilon health, inc.	−6,240,000	260,000	$2,056,600
FOLD	AMICUS THERAPEUTICS, INC.	−1,908,869	21,062	$304,556
GOSS	Gossamer Bio, Inc.	−1,657,468	1,609,492	$529,522
TVTX	Travere Therapeutics, Inc.	−732,368	1,477,954	$43,910,013
CMPX	Compass Therapeutics, Inc.	−621,894	3,305,308	$17,485,079
PHR	Phreesia, Inc.	−276,200	600,400	$5,031,352
COGT	Cogent Biosciences, Inc.	−224,875	624,155	$24,023,725
OMDA	Omada Health, Inc.	−199,000	541,000	$6,800,370
RVMD	Revolution Medicines, Inc.	−125,805	1,209,465	$117,620,471
CAI	Caris Life Sciences, Inc.	−124,500	563,000	$10,066,440
GPCR	Structure Therapeutics Inc.	−108,019	640,217	$30,858,459
SGRY	Surgery Partners, Inc.	−102,000	208,000	$2,479,360
VERA	Vera Therapeutics, Inc.	−64,994	503,585	$20,259,224
EW	Edwards Lifesciences Corp	−53,600	28,900	$2,314,312
RARE	Ultragenyx Pharmaceutical Inc.	−48,468	1,218,773	$25,533,294
ACHC	Acadia Healthcare Company, Inc.	−44,500	75,500	$1,765,945
CLDX	Celldex Therapeutics, Inc.	−42,268	650,270	$20,626,564
TARS	Tarsus Pharmaceuticals, Inc.	−35,165	225,179	$15,796,306
XENE	Xenon Pharmaceuticals Inc.	−24,768	763,020	$44,369,613
ASND	Ascendis Pharma A/S	−9,500	194,000	$44,373,620
LLY	ELI LILLY & Co	−6,700	98,700	$90,781,299
RYTM	Rhythm Pharmaceuticals, Inc.	−5,262	689,748	$59,987,383
INSM	INSMED Inc	−4,950	314,300	$51,394,336
ARGX	Argenx SE	−4,750	98,500	$71,929,625
No positions match the current search.

New Positions

Positions the filer opened this quarter

10 positions

Ticker	Company	Shares	Value
MMED	MiniMed Group, Inc.	1,055,000	$15,740,600
INDV	Indivior Pharmaceuticals, Inc.	200,000	$6,096,000
SYK	Stryker Corp	14,800	$4,863,132
NVO	Novo Nordisk A S	90,000	$3,307,500
VKTX	Viking Therapeutics, Inc.	96,000	$3,123,840
IPSC	Century Therapeutics, Inc.	1,304,347	$2,947,824
CVS	CVS HEALTH Corp	40,000	$2,872,800
DNTH	Dianthus Therapeutics, Inc. /DE/	26,757	$2,245,447
ORKA	Oruka Therapeutics, Inc.	4,123	$202,233
BCRX	Biocryst Pharmaceuticals Inc	12,600	$119,952
No positions match the current search.

Sold Out

Positions the filer fully exited

2 positions

Ticker	Company	Shares	Value
EXAS	EXACT SCIENCES CORP	601,800	$61,118,808
TBPH	Theravance Biopharma, Inc.	208,771	$3,906,105
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

99 tracked positions · $1,692,833,901 total · as of Mar 31, 2026

All sectors Healthcare

Showing 1–50 of 99 positions by value · page 1 of 2

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	% of Portfolio
RVMD	Revolution Medicines, Inc. Healthcare	Reduced	1,209,465	-125,805	$117,620,471	+10.6%	6.95%
LLY	ELI LILLY & Co Healthcare	Reduced	98,700	-6,700	$90,781,299	−19.9%	5.36%
MDGL	Madrigal Pharmaceuticals, Inc. Healthcare	Added	170,999	+31,381	$89,512,846	+10.1%	5.29%
MIRM	Mirum Pharmaceuticals, Inc. Healthcare	Added	811,294	+49,000	$74,947,339	+24.5%	4.43%
ARGX	Argenx SE Healthcare	Reduced	98,500	-4,750	$71,929,625	−17.2%	4.25%
RYTM	Rhythm Pharmaceuticals, Inc. Healthcare	Reduced	689,748	-5,262	$59,987,383	−19.4%	3.54%
INSM	INSMED Inc Healthcare	Reduced	314,300	-4,950	$51,394,336	−7.5%	3.04%
ASND	Ascendis Pharma A/S Healthcare	Reduced	194,000	-9,500	$44,373,620	+2.3%	2.62%
XENE	Xenon Pharmaceuticals Inc. Healthcare	Reduced	763,020	-24,768	$44,369,613	+25.7%	2.62%
TVTX	Travere Therapeutics, Inc. Healthcare	Reduced	1,477,954	-732,368	$43,910,013	−48.0%	2.59%
KYMR	Kymera Therapeutics, Inc. Healthcare	Held	496,871	0	$41,384,385	+7.0%	2.44%
PEN	Penumbra Inc Healthcare	Held	120,500	0	$39,568,585	+5.6%	2.34%
ISRG	Intuitive Surgical Inc Healthcare	Held	82,000	0	$37,801,180	−18.6%	2.23%
SRRK	Scholar Rock Holding Corp Healthcare	Added	739,816	+6,339	$36,369,354	+12.6%	2.15%
ELVN	Enliven Therapeutics, Inc. Healthcare	Added	826,500	+28,095	$32,398,800	+163.5%	1.91%
BSX	Boston Scientific Corp Healthcare	Added	515,300	+116,250	$32,335,075	−15.0%	1.91%
IRTC	iRhythm Holdings, Inc. Healthcare	Added	261,750	+26,750	$30,891,735	−25.9%	1.82%
GPCR	Structure Therapeutics Inc. Healthcare	Reduced	640,217	-108,019	$30,858,459	−40.7%	1.82%
AGIO	Agios Pharmaceuticals, Inc. Healthcare	Held	799,163	0	$27,035,684	+24.3%	1.60%
RARE	Ultragenyx Pharmaceutical Inc. Healthcare	Reduced	1,218,773	-48,468	$25,533,294	−12.4%	1.51%
ALNY	Alnylam Pharmaceuticals, Inc. Healthcare	Added	74,000	+2,750	$24,484,380	−13.6%	1.45%
COGT	Cogent Biosciences, Inc. Healthcare	Reduced	624,155	-224,875	$24,023,725	−20.3%	1.42%
THC	Tenet Healthcare Corp Healthcare	Held	125,000	0	$23,588,750	−5.0%	1.39%
DXCM	Dexcom Inc Healthcare	Added	355,600	+8,300	$22,331,680	−3.1%	1.32%
CLDX	Celldex Therapeutics, Inc. Healthcare	Reduced	650,270	-42,268	$20,626,564	+9.7%	1.22%
VERA	Vera Therapeutics, Inc. Healthcare	Reduced	503,585	-64,994	$20,259,224	−29.6%	1.20%
NBIX	Neurocrine Biosciences Inc Healthcare	Added	150,450	+24,950	$19,820,283	+11.4%	1.17%
ACLX	Arcellx, Inc. Healthcare	Held	169,859	0	$19,503,210	+76.1%	1.15%
NAMS	NewAmsterdam Pharma Co N.V. Healthcare	Held	588,794	0	$18,847,295	−8.8%	1.11%
PHVS	Pharvaris N.V. Healthcare	Added	645,533	+22,131	$18,236,307	+5.4%	1.08%
ERAS	Erasca, Inc. Healthcare	Added	1,103,469	+151,759	$17,854,128	+404.3%	1.05%
DYN	Dyne Therapeutics, Inc. Healthcare	Added	972,198	+59,243	$17,625,949	−1.3%	1.04%
CMPX	Compass Therapeutics, Inc. Healthcare	Reduced	3,305,308	-621,894	$17,485,079	−17.1%	1.03%
ACRS	Aclaris Therapeutics, Inc. Healthcare	Added	4,472,650	+18,909	$16,772,437	+25.1%	0.99%
TARS	Tarsus Pharmaceuticals, Inc. Healthcare	Reduced	225,179	-35,165	$15,796,306	−25.9%	0.93%
MMED	MiniMed Group, Inc. Healthcare	NEW	1,055,000	NEW	$15,740,600	NEW	0.93%
ZLAB	Zai Lab Ltd Healthcare	Added	814,707	+3,161	$15,324,638	+7.0%	0.91%
UNH	Unitedhealth Group Inc Healthcare	Added	53,000	+12,200	$14,341,270	+6.5%	0.85%
CNTA	Centessa Pharmaceuticals plc Healthcare	Added	351,828	+27,813	$13,974,608	+72.4%	0.83%
HTFL	Heartflow, Inc. Healthcare	Added	572,500	+294,800	$13,928,925	+72.1%	0.82%
ARDX	Ardelyx, Inc. Healthcare	Held	2,299,473	0	$13,773,843	+2.7%	0.81%
SMMT	Summit Therapeutics Inc. Healthcare	Held	710,000	0	$13,461,600	+8.4%	0.80%
AZTA	Azenta, Inc. Healthcare	Held	569,100	0	$12,025,083	−36.5%	0.71%
MLYS	Mineralys Therapeutics, Inc. Healthcare	Added	439,751	+12,155	$11,912,854	−23.2%	0.70%
DHR	Danaher Corp /De/ Healthcare	Held	61,500	0	$11,660,400	−17.2%	0.69%
PTCT	Ptc Therapeutics, Inc. Healthcare	Added	161,798	+99,919	$11,023,297	+134.5%	0.65%
CAI	Caris Life Sciences, Inc. Healthcare	Reduced	563,000	-124,500	$10,066,440	−45.7%	0.59%
ZBIO	Zenas BioPharma, Inc. Healthcare	Held	502,077	0	$9,815,605	−46.2%	0.58%
BCAX	Bicara Therapeutics Inc. Healthcare	Added	489,095	+60,000	$9,728,099	+34.7%	0.57%
BBIO	BridgeBio Pharma, Inc. Healthcare	Added	128,250	+24,750	$9,523,845	+20.3%	0.56%

Covers the securities this platform tracks: U.S.-listed common stock and the put/call positions reported on it. A 13F can also report security types outside that coverage — preferred shares, bonds, warrants, untracked share classes — so the filing's own declared total can exceed the figures above. The source filing is linked at the top of this table.