Ishara Investments LP
Filing Date
Global Rank
#5,612
/ 8,622
▲ 542
· as of Mar 2026
Top Industry
Biotechnology
94.4%
3Y Alpha vs SPY
+9.9%
Period ended 4 months ago
Filed May 15, 2026 · 3mo
2 quarters · since Dec 2025
Clone Performance
Feb 2026–Jul 2026 · vs SPYHypothetical growth of buying every stock this filer reported holding, rebalancing on each filing and indexed to the same start. Option positions cannot be bought this way and are left out.
Cloned portfolio
+11.6%
SPY
+9.0%
Annualised alpha
+6.5%
Max drawdown
−13.1%
Estimate. 13F holdings are quarter-lagged, so the clone rebalances about 45 days after each period end — when the filing becomes public — and it excludes option and short positions. It tracks 96% of reported value on average across 2 quarters. Past performance does not predict future results.
Portfolio Concentration
36 tracked positions · as of Mar 31, 2026 · Δ vs Dec 31, 2025Top Position
13.1%
−0.5 pts
Top 5
35.6%
−3.0 pts
Top 10
54.0%
−2.5 pts
HHI
467
Diversified−22
Portfolio Trend
2 quarters · across all stocks
Sector Breakdown
As of Mar 31, 2026| Sector | % Portfolio | Value |
|---|---|---|
| Healthcare | 100.0% | $105,625,564 |
Last Quarter's Activity
Export CSVAdded To
Positions the filer increased
11 positions
| Ticker | Company | Δ Shares | Shares | Value | Open |
|---|---|---|---|---|---|
| VSTM | Verastem, Inc. | +550,000 | 820,000 | $4,346,000 | |
| XERS | Xeris Biopharma Holdings, Inc. | +225,000 | 1,025,000 | $5,945,000 | |
| RARE | Ultragenyx Pharmaceutical Inc. | +124,250 | 174,250 | $3,650,537 | |
| IMTX | Immatics N.V. | +73,750 | 153,750 | $1,512,900 | |
| LXRX | Lexicon Pharmaceuticals, Inc. | +22,000 | 902,000 | $1,407,120 | |
| GMAB | Genmab A/S | +12,000 | 82,000 | $2,200,060 | |
| FOLD | AMICUS THERAPEUTICS, INC. | +9,000 | 369,000 | $5,335,740 | |
| PCVX | Vaxcyte, Inc. | +7,400 | 57,400 | $3,335,514 | |
| BEAM | Beam Therapeutics Inc. | +7,400 | 57,400 | $1,367,842 | |
| NAMS | NewAmsterdam Pharma Co N.V. | +6,900 | 36,900 | $1,181,169 | |
| PRAX | Praxis Precision Medicines, Inc. | +3,050 | 43,050 | $13,870,279 | |
| No positions match the current search. | |||||
Trimmed
Positions the filer reduced
8 positions
| Ticker | Company | Δ Shares | Shares | Value | Open |
|---|---|---|---|---|---|
| ANNX | Annexon, Inc. | −575,750 | 174,250 | $965,345 | |
| SLN | Silence Therapeutics plc | −99,500 | 140,500 | $740,435 | |
| ZNTL | Zentalis Pharmaceuticals, Inc. | −90,000 | 1,230,000 | $2,878,200 | |
| ORIC | Oric Pharmaceuticals, Inc. | −57,500 | 102,500 | $1,298,675 | |
| ACAD | Acadia Pharmaceuticals Inc | −37,000 | 123,000 | $2,737,980 | |
| PTCT | Ptc Therapeutics, Inc. | −25,750 | 10,250 | $698,332 | |
| BMRN | Biomarin Pharmaceutical Inc | −18,000 | 82,000 | $4,632,180 | |
| EWTX | Edgewise Therapeutics, Inc. | −8,800 | 49,200 | $1,549,800 | |
| No positions match the current search. | |||||
New Positions
Positions the filer opened this quarter
17 positions
| Ticker | Company | Shares | Value | Open |
|---|---|---|---|---|
| AXSM | Axsome Therapeutics, Inc. | 41,000 | $6,929,820 | |
| KALV | KalVista Pharmaceuticals, Inc. | 276,750 | $5,570,977 | |
| ARWR | Arrowhead Pharmaceuticals, Inc. | 55,350 | $3,470,445 | |
| VERA | Vera Therapeutics, Inc. | 82,000 | $3,298,860 | |
| TVTX | Travere Therapeutics, Inc. | 110,700 | $3,288,897 | |
| MLTX | MoonLake Immunotherapeutics | 174,250 | $3,248,020 | |
| SRRK | Scholar Rock Holding Corp | 57,400 | $2,821,784 | |
| ARDX | Ardelyx, Inc. | 451,000 | $2,701,490 | |
| MLYS | Mineralys Therapeutics, Inc. | 82,000 | $2,221,380 | |
| DBVT | DBV Technologies S.A. | 102,500 | $2,141,225 | |
| CPRX | Catalyst Pharmaceuticals, Inc. | 82,000 | $2,030,320 | |
| SION | Sionna Therapeutics, Inc. | 49,200 | $1,972,428 | |
| CTNM | Contineum Therapeutics, Inc. | 142,000 | $1,854,520 | |
| ALNY | Alnylam Pharmaceuticals, Inc. | 5,125 | $1,695,708 | |
| LGND | Ligand Pharmaceuticals Inc | 8,200 | $1,637,130 | |
| IDYA | IDEAYA Biosciences, Inc. | 24,600 | $819,672 | |
| GOSS | Gossamer Bio, Inc. | 820,000 | $269,780 | |
| No positions match the current search. | ||||
Sold Out
Positions the filer fully exited
19 positions
| Ticker | Company | Shares | Value | Open |
|---|---|---|---|---|
| NUVB | Nuvation Bio Inc. | 400,000 | $3,584,000 | |
| BBIO | BridgeBio Pharma, Inc. | 36,000 | $2,753,640 | |
| UTHR | UNITED THERAPEUTICS Corp | 5,500 | $2,679,875 | |
| BCRX | Biocryst Pharmaceuticals Inc | 300,000 | $2,340,000 | |
| SNDX | Syndax Pharmaceuticals Inc | 100,000 | $2,101,000 | |
| TARS | Tarsus Pharmaceuticals, Inc. | 24,000 | $1,965,120 | |
| INSM | INSMED Inc | 10,000 | $1,740,400 | |
| CORT | Corcept Therapeutics Inc | 44,000 | $1,531,200 | |
| APLS | Apellis Pharmaceuticals, Inc. | 50,000 | $1,256,000 | |
| DNLI | Denali Therapeutics Inc. | 70,000 | $1,155,700 | |
| ASND | Ascendis Pharma A/S | 5,000 | $1,066,200 | |
| BHVN | Biohaven Ltd. | 88,000 | $993,520 | |
| DNTH | Dianthus Therapeutics, Inc. /DE/ | 24,000 | $989,040 | |
| APOG | Apogee Enterprises, Inc. | 25,000 | $910,250 | |
| NKTR | Nektar Therapeutics | 20,000 | $845,600 | |
| AGIO | Agios Pharmaceuticals, Inc. | 30,000 | $816,600 | |
| IMVT | Immunovant, Inc. | 30,000 | $762,600 | |
| OLMA | Olema Pharmaceuticals, Inc. | 30,000 | $750,000 | |
| ARQT | Arcutis Biotherapeutics, Inc. | 12,000 | $348,480 | |
| No positions match the current search. | ||||
36 tracked positions ·
$105,625,564 total
· filing declares
37 positions · $105,625,159
· as of Mar 31, 2026
| Ticker | Company | Type | Shares | Value (USD) | % of Portfolio | History |
|---|---|---|---|---|---|---|
| PRAX |
Praxis Precision Medicines, Inc.
PUT
+ SHARES
Healthcare
|
Added | 43,050 | $13,870,279 | 13.13% | |
| AXSM |
Axsome Therapeutics, Inc.
Healthcare
|
NEW | 41,000 | $6,929,820 | 6.56% | |
| XERS |
Xeris Biopharma Holdings, Inc.
Healthcare
|
Added | 1,025,000 | $5,945,000 | 5.63% | |
| KALV |
KalVista Pharmaceuticals, Inc.
Healthcare
|
NEW | 276,750 | $5,570,977 | 5.27% | |
| FOLD |
AMICUS THERAPEUTICS, INC.
Healthcare
|
Added | 369,000 | $5,335,740 | 5.05% | |
| BMRN |
Biomarin Pharmaceutical Inc
Healthcare
|
Reduced | 82,000 | $4,632,180 | 4.39% | |
| VSTM |
Verastem, Inc.
Healthcare
|
Added | 820,000 | $4,346,000 | 4.11% | |
| RARE |
Ultragenyx Pharmaceutical Inc.
Healthcare
|
Added | 174,250 | $3,650,537 | 3.46% | |
| ARWR |
Arrowhead Pharmaceuticals, Inc.
Healthcare
|
NEW | 55,350 | $3,470,445 | 3.29% | |
| PCVX |
Vaxcyte, Inc.
Healthcare
|
Added | 57,400 | $3,335,514 | 3.16% | |
| VERA |
Vera Therapeutics, Inc.
Healthcare
|
NEW | 82,000 | $3,298,860 | 3.12% | |
| TVTX |
Travere Therapeutics, Inc.
Healthcare
|
NEW | 110,700 | $3,288,897 | 3.11% | |
| MLTX |
MoonLake Immunotherapeutics
Healthcare
|
NEW | 174,250 | $3,248,020 | 3.08% | |
| ZNTL |
Zentalis Pharmaceuticals, Inc.
Healthcare
|
Reduced | 1,230,000 | $2,878,200 | 2.72% | |
| SRRK |
Scholar Rock Holding Corp
Healthcare
|
NEW | 57,400 | $2,821,784 | 2.67% | |
| ACAD |
Acadia Pharmaceuticals Inc
Healthcare
|
Reduced | 123,000 | $2,737,980 | 2.59% | |
| ARDX |
Ardelyx, Inc.
Healthcare
|
NEW | 451,000 | $2,701,490 | 2.56% | |
| MLYS |
Mineralys Therapeutics, Inc.
Healthcare
|
NEW | 82,000 | $2,221,380 | 2.10% | |
| GMAB |
Genmab A/S
Healthcare
|
Added | 82,000 | $2,200,060 | 2.08% | |
| DBVT |
DBV Technologies S.A.
Healthcare
|
NEW | 102,500 | $2,141,225 | 2.03% | |
| CPRX |
Catalyst Pharmaceuticals, Inc.
Healthcare
|
NEW | 82,000 | $2,030,320 | 1.92% | |
| SION |
Sionna Therapeutics, Inc.
Healthcare
|
NEW | 49,200 | $1,972,428 | 1.87% | |
| CTNM |
Contineum Therapeutics, Inc.
Healthcare
|
NEW | 142,000 | $1,854,520 | 1.76% | |
| ALNY |
Alnylam Pharmaceuticals, Inc.
Healthcare
|
NEW | 5,125 | $1,695,708 | 1.61% | |
| LGND |
Ligand Pharmaceuticals Inc
Healthcare
|
NEW | 8,200 | $1,637,130 | 1.55% | |
| EWTX |
Edgewise Therapeutics, Inc.
Healthcare
|
Reduced | 49,200 | $1,549,800 | 1.47% | |
| IMTX |
Immatics N.V.
Healthcare
|
Added | 153,750 | $1,512,900 | 1.43% | |
| LXRX |
Lexicon Pharmaceuticals, Inc.
Healthcare
|
Added | 902,000 | $1,407,120 | 1.33% | |
| BEAM |
Beam Therapeutics Inc.
Healthcare
|
Added | 57,400 | $1,367,842 | 1.29% | |
| ORIC |
Oric Pharmaceuticals, Inc.
Healthcare
|
Reduced | 102,500 | $1,298,675 | 1.23% | |
| NAMS |
NewAmsterdam Pharma Co N.V.
Healthcare
|
Added | 36,900 | $1,181,169 | 1.12% | |
| ANNX |
Annexon, Inc.
Healthcare
|
Reduced | 174,250 | $965,345 | 0.91% | |
| IDYA |
IDEAYA Biosciences, Inc.
Healthcare
|
NEW | 24,600 | $819,672 | 0.78% | |
| SLN |
Silence Therapeutics plc
Healthcare
|
Reduced | 140,500 | $740,435 | 0.70% | |
| PTCT |
Ptc Therapeutics, Inc.
Healthcare
|
Reduced | 10,250 | $698,332 | 0.66% | |
| GOSS |
Gossamer Bio, Inc.
Healthcare
|
NEW | 820,000 | $269,780 | 0.26% |
Covers the securities this platform tracks: U.S.-listed common stock and the put/call positions reported on it. A 13F can also report security types outside that coverage — preferred shares, bonds, warrants, untracked share classes — so the filing's own declared total can exceed the figures above. The source filing is linked at the top of this table.