Ishara Investments LP

CIK

2111609

Location

LOS ANGELES, CA

Portfolio Value

Small $105,625,564

Diversification

Diversified

Filing Date

Global Rank

#5,248 / 8,232 ▲ 671

Top Industry

Biotechnology 94.4%

3Y Alpha vs SPY

-27.2%

Period ended 2 months ago

Filed May 15, 2026 · 30d

2 quarters · since Dec 2025

Clone Performance

Feb 2026–Jun 2026 · vs SPY

Hypothetical growth of cloning every reported 13F position and rebalancing on each filing, indexed to the same start.

Cloned portfolio

+1.0%

SPY

+9.1%

Annualised alpha

-27.2%

Max drawdown

−13.2%

Estimate. 13F holdings are quarter-lagged and long-only, so the clone rebalances about 45 days after each period end — when the filing becomes public — and excludes options and short positions. Past performance does not predict future results.

Portfolio Concentration

36 positions · as of Mar 31, 2026 · Δ vs Dec 31, 2025

Top Position

13.1%

−0.5 pts

Top 5

35.6%

−3.0 pts

Top 10

54.0%

−2.5 pts

HHI

467

Diversified−22

Portfolio Trend

2 quarters · across all stocks

Sector Breakdown

As of Mar 31, 2026

Sector	% Portfolio	Value	Positions
Healthcare	100.0%	$105,625,564	36

Last Quarter's Activity

Export CSV

Mar 31, 2026 vs Dec 31, 2025

Added To

Positions the filer increased

11 positions

Ticker	Company	Δ Shares	Shares	Value
VSTM	Verastem, Inc.	+550,000	820,000	$4,346,000
XERS	Xeris Biopharma Holdings, Inc.	+225,000	1,025,000	$5,945,000
RARE	Ultragenyx Pharmaceutical Inc.	+124,250	174,250	$3,650,537
IMTX	Immatics N.V.	+73,750	153,750	$1,512,900
LXRX	Lexicon Pharmaceuticals, Inc.	+22,000	902,000	$1,407,120
GMAB	Genmab A/S	+12,000	82,000	$2,200,060
FOLD	AMICUS THERAPEUTICS, INC.	+9,000	369,000	$5,335,740
PCVX	Vaxcyte, Inc.	+7,400	57,400	$3,335,514
BEAM	Beam Therapeutics Inc.	+7,400	57,400	$1,367,842
NAMS	NewAmsterdam Pharma Co N.V.	+6,900	36,900	$1,181,169
PRAX	Praxis Precision Medicines, Inc.	+3,050	43,050	$13,870,279
No positions match the current search.

Trimmed

Positions the filer reduced

8 positions

Ticker	Company	Δ Shares	Shares	Value
ANNX	Annexon, Inc.	−575,750	174,250	$965,345
SLN	Silence Therapeutics plc	−99,500	140,500	$740,435
ZNTL	Zentalis Pharmaceuticals, Inc.	−90,000	1,230,000	$2,878,200
ORIC	Oric Pharmaceuticals, Inc.	−57,500	102,500	$1,298,675
ACAD	Acadia Pharmaceuticals Inc	−37,000	123,000	$2,737,980
PTCT	Ptc Therapeutics, Inc.	−25,750	10,250	$698,332
BMRN	Biomarin Pharmaceutical Inc	−18,000	82,000	$4,632,180
EWTX	Edgewise Therapeutics, Inc.	−8,800	49,200	$1,549,800
No positions match the current search.

New Positions

Positions the filer opened this quarter

17 positions

Ticker	Company	Shares	Value
AXSM	Axsome Therapeutics, Inc.	41,000	$6,929,820
KALV	KalVista Pharmaceuticals, Inc.	276,750	$5,570,977
ARWR	Arrowhead Pharmaceuticals, Inc.	55,350	$3,470,445
VERA	Vera Therapeutics, Inc.	82,000	$3,298,860
TVTX	Travere Therapeutics, Inc.	110,700	$3,288,897
MLTX	MoonLake Immunotherapeutics	174,250	$3,248,020
SRRK	Scholar Rock Holding Corp	57,400	$2,821,784
ARDX	Ardelyx, Inc.	451,000	$2,701,490
MLYS	Mineralys Therapeutics, Inc.	82,000	$2,221,380
DBVT	DBV Technologies S.A.	102,500	$2,141,225
CPRX	Catalyst Pharmaceuticals, Inc.	82,000	$2,030,320
SION	Sionna Therapeutics, Inc.	49,200	$1,972,428
CTNM	Contineum Therapeutics, Inc.	142,000	$1,854,520
ALNY	Alnylam Pharmaceuticals, Inc.	5,125	$1,695,708
LGND	Ligand Pharmaceuticals Inc	8,200	$1,637,130
IDYA	IDEAYA Biosciences, Inc.	24,600	$819,672
GOSS	Gossamer Bio, Inc.	820,000	$269,780
No positions match the current search.

Sold Out

Positions the filer fully exited

19 positions

Ticker	Company	Shares	Value
NUVB	Nuvation Bio Inc.	400,000	$3,584,000
BBIO	BridgeBio Pharma, Inc.	36,000	$2,753,640
UTHR	UNITED THERAPEUTICS Corp	5,500	$2,679,875
BCRX	Biocryst Pharmaceuticals Inc	300,000	$2,340,000
SNDX	Syndax Pharmaceuticals Inc	100,000	$2,101,000
TARS	Tarsus Pharmaceuticals, Inc.	24,000	$1,965,120
INSM	INSMED Inc	10,000	$1,740,400
CORT	Corcept Therapeutics Inc	44,000	$1,531,200
APLS	Apellis Pharmaceuticals, Inc.	50,000	$1,256,000
DNLI	Denali Therapeutics Inc.	70,000	$1,155,700
ASND	Ascendis Pharma A/S	5,000	$1,066,200
BHVN	Biohaven Ltd.	88,000	$993,520
DNTH	Dianthus Therapeutics, Inc. /DE/	24,000	$989,040
APOG	Apogee Enterprises, Inc.	25,000	$910,250
NKTR	Nektar Therapeutics	20,000	$845,600
AGIO	Agios Pharmaceuticals, Inc.	30,000	$816,600
IMVT	Immunovant, Inc.	30,000	$762,600
OLMA	Olema Pharmaceuticals, Inc.	30,000	$750,000
ARQT	Arcutis Biotherapeutics, Inc.	12,000	$348,480
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

36 positions · $105,625,564 total · as of Mar 31, 2026

All sectors Healthcare

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	% of Portfolio
PRAX	Praxis Precision Medicines, Inc. Healthcare	Added	43,050	+3,050	$13,870,279	+17.6%	13.13%
AXSM	Axsome Therapeutics, Inc. Healthcare	NEW	41,000	NEW	$6,929,820	NEW	6.56%
XERS	Xeris Biopharma Holdings, Inc. Healthcare	Added	1,025,000	+225,000	$5,945,000	−5.3%	5.63%
KALV	KalVista Pharmaceuticals, Inc. Healthcare	NEW	276,750	NEW	$5,570,977	NEW	5.27%
FOLD	AMICUS THERAPEUTICS, INC. Healthcare	Added	369,000	+9,000	$5,335,740	+4.1%	5.05%
BMRN	Biomarin Pharmaceutical Inc Healthcare	Reduced	82,000	-18,000	$4,632,180	−22.1%	4.39%
VSTM	Verastem, Inc. Healthcare	Added	820,000	+550,000	$4,346,000	+108.5%	4.11%
RARE	Ultragenyx Pharmaceutical Inc. Healthcare	Added	174,250	+124,250	$3,650,537	+217.4%	3.46%
ARWR	Arrowhead Pharmaceuticals, Inc. Healthcare	NEW	55,350	NEW	$3,470,445	NEW	3.29%
PCVX	Vaxcyte, Inc. Healthcare	Added	57,400	+7,400	$3,335,514	+44.6%	3.16%
VERA	Vera Therapeutics, Inc. Healthcare	NEW	82,000	NEW	$3,298,860	NEW	3.12%
TVTX	Travere Therapeutics, Inc. Healthcare	NEW	110,700	NEW	$3,288,897	NEW	3.11%
MLTX	MoonLake Immunotherapeutics Healthcare	NEW	174,250	NEW	$3,248,020	NEW	3.08%
ZNTL	Zentalis Pharmaceuticals, Inc. Healthcare	Reduced	1,230,000	-90,000	$2,878,200	+61.5%	2.72%
SRRK	Scholar Rock Holding Corp Healthcare	NEW	57,400	NEW	$2,821,784	NEW	2.67%
ACAD	Acadia Pharmaceuticals Inc Healthcare	Reduced	123,000	-37,000	$2,737,980	−35.9%	2.59%
ARDX	Ardelyx, Inc. Healthcare	NEW	451,000	NEW	$2,701,490	NEW	2.56%
MLYS	Mineralys Therapeutics, Inc. Healthcare	NEW	82,000	NEW	$2,221,380	NEW	2.10%
GMAB	Genmab A/S Healthcare	Added	82,000	+12,000	$2,200,060	+2.0%	2.08%
DBVT	DBV Technologies S.A. Healthcare	NEW	102,500	NEW	$2,141,225	NEW	2.03%
CPRX	Catalyst Pharmaceuticals, Inc. Healthcare	NEW	82,000	NEW	$2,030,320	NEW	1.92%
SION	Sionna Therapeutics, Inc. Healthcare	NEW	49,200	NEW	$1,972,428	NEW	1.87%
CTNM	Contineum Therapeutics, Inc. Healthcare	NEW	142,000	NEW	$1,854,520	NEW	1.76%
ALNY	Alnylam Pharmaceuticals, Inc. Healthcare	NEW	5,125	NEW	$1,695,708	NEW	1.61%
LGND	Ligand Pharmaceuticals Inc Healthcare	NEW	8,200	NEW	$1,637,130	NEW	1.55%
EWTX	Edgewise Therapeutics, Inc. Healthcare	Reduced	49,200	-8,800	$1,549,800	+7.7%	1.47%
IMTX	Immatics N.V. Healthcare	Added	153,750	+73,750	$1,512,900	+80.1%	1.43%
LXRX	Lexicon Pharmaceuticals, Inc. Healthcare	Added	902,000	+22,000	$1,407,120	+39.0%	1.33%
BEAM	Beam Therapeutics Inc. Healthcare	Added	57,400	+7,400	$1,367,842	−1.3%	1.29%
ORIC	Oric Pharmaceuticals, Inc. Healthcare	Reduced	102,500	-57,500	$1,298,675	−0.8%	1.23%
NAMS	NewAmsterdam Pharma Co N.V. Healthcare	Added	36,900	+6,900	$1,181,169	+12.2%	1.12%
ANNX	Annexon, Inc. Healthcare	Reduced	174,250	-575,750	$965,345	−74.4%	0.91%
IDYA	IDEAYA Biosciences, Inc. Healthcare	NEW	24,600	NEW	$819,672	NEW	0.78%
SLN	Silence Therapeutics plc Healthcare	Reduced	140,500	-99,500	$740,435	−49.3%	0.70%
PTCT	Ptc Therapeutics, Inc. Healthcare	Reduced	10,250	-25,750	$698,332	−74.5%	0.66%
GOSS	Gossamer Bio, Inc. Healthcare	NEW	820,000	NEW	$269,780	NEW	0.26%