INTERNATIONAL BIOTECHNOLOGY TRUST PLC

CIK

942257

Location

LONDON, X0

Portfolio Value

Small $253,568,997

Diversification

Diversified

Filing Date

Global Rank

#2,864 / 6,895 ▼ 102

Top Industry

Biotechnology 66.0%

3Y Alpha vs SPY

-5.2%

Period ended 2 years ago

Filed Nov 14, 2023 · 2y

15 quarters · since Mar 2020

Clone Performance

Jun 2023–Jun 2026 · vs SPY

Hypothetical growth of cloning every reported 13F position and rebalancing on each filing, indexed to the same start.

Cloned portfolio

+54.5%

SPY

+76.3%

Annualised alpha

-5.2%

Max drawdown

−27.9%

Estimate. 13F holdings are quarter-lagged and long-only, so the clone rebalances about 45 days after each period end — when the filing becomes public — and excludes options and short positions. Past performance does not predict future results.

Portfolio Concentration

55 positions · as of Sep 30, 2023 · Δ vs Jun 30, 2023

Top Position

8.4%

−0.8 pts

Top 5

33.5%

−3.3 pts

Top 10

52.5%

−7.5 pts

HHI

393

Diversified−60

Portfolio Trend

15 quarters · across all stocks

Sector Breakdown

As of Sep 30, 2023

Sector	% Portfolio	Value	Positions
Healthcare	100.0%	$253,568,997	55

Last Quarter's Activity

Export CSV

Sep 30, 2023 vs Jun 30, 2023

Added To

Positions the filer increased

15 positions

Ticker	Company	Δ Shares	Shares	Value
QURE	uniQure N.V.	+1,226,000	1,241,500	$8,330,465
ERAS	Erasca, Inc.	+500,000	1,926,000	$3,794,220
AUPH	Aurinia Pharmaceuticals Inc.	+467,000	1,040,530	$8,084,918
IOVA	Iovance Biotherapeutics, Inc.	+380,000	445,000	$2,024,750
AMLX	Amylyx Pharmaceuticals, Inc.	+270,000	295,000	$5,401,450
RARE	Ultragenyx Pharmaceutical Inc.	+170,000	250,052	$8,914,353
BMRN	Biomarin Pharmaceutical Inc	+95,000	153,656	$13,595,482
GILD	Gilead Sciences, Inc.	+89,000	233,584	$17,504,784
XENE	Xenon Pharmaceuticals Inc.	+66,000	91,500	$3,125,640
NVCR	NovoCure Ltd	+42,000	74,000	$1,195,100
BIIB	Biogen Inc.	+29,200	40,200	$10,331,802
ACAD	Acadia Pharmaceuticals Inc	+28,702	179,702	$3,744,989
SRPT	Sarepta Therapeutics, Inc.	+7,900	26,700	$3,236,574
ONC	BeOne Medicines Ltd.	+4,000	12,700	$2,284,349
KRYS	Krystal Biotech, Inc.	+147	46,092	$5,346,672
No positions match the current search.

Trimmed

Positions the filer reduced

11 positions

Ticker	Company	Δ Shares	Shares	Value
HRMY	Harmony Biosciences Holdings, Inc.	−256,000	314,500	$10,306,165
VERA	Vera Therapeutics, Inc.	−216,872	758,355	$10,397,047
DYN	Dyne Therapeutics, Inc.	−163,000	137,751	$1,234,248
SUPN	Supernus Pharmaceuticals, Inc.	−97,000	426,500	$11,758,605
ALNY	Alnylam Pharmaceuticals, Inc.	−44,800	36,800	$6,517,280
NBIX	Neurocrine Biosciences Inc	−40,000	28,877	$3,248,662
AMGN	Amgen Inc	−38,000	79,246	$21,298,154
DNLI	Denali Therapeutics Inc.	−34,000	154,000	$3,177,020
HALO	Halozyme Therapeutics, Inc.	−33,300	62,200	$2,376,040
UTHR	UNITED THERAPEUTICS Corp	−18,800	33,959	$7,670,319
REGN	Regeneron Pharmaceuticals, Inc.	−18,153	8,847	$7,280,727
No positions match the current search.

New Positions

Positions the filer opened this quarter

6 positions

Ticker	Company	Shares	Value
CRSP	CRISPR Therapeutics AG	63,000	$2,859,570
GMAB	Genmab A/S	44,300	$1,562,461
COGT	Cogent Biosciences, Inc.	135,000	$1,316,250
FOLD	AMICUS THERAPEUTICS, INC.	90,000	$1,094,400
PRTA	Prothena Corp Public Ltd Co	15,000	$723,750
VIR	Vir Biotechnology, Inc.	47,000	$440,390
No positions match the current search.

Sold Out

Positions the filer fully exited

3 positions

Ticker	Company	Shares	Value
APLS	Apellis Pharmaceuticals, Inc.	129,700	$11,815,670
TVTX	Travere Therapeutics, Inc.	441,019	$6,774,051
HCM	HUTCHMED (China) Ltd	68,000	$816,000
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

55 positions · $253,568,997 total · as of Sep 30, 2023

All sectors Healthcare

Showing 1–50 of 55 positions by value · page 1 of 2

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	% of Portfolio
AMGN	Amgen Inc Healthcare	Reduced	79,246	-38,000	$21,298,154	−18.2%	8.40%
INCY	Incyte Corp Healthcare	Held	358,454	0	$20,707,887	−7.2%	8.17%
GILD	Gilead Sciences, Inc. Healthcare	Added	233,584	+89,000	$17,504,784	+57.1%	6.90%
BMRN	Biomarin Pharmaceutical Inc Healthcare	Added	153,656	+95,000	$13,595,482	+167.4%	5.36%
SUPN	Supernus Pharmaceuticals, Inc. Healthcare	Reduced	426,500	-97,000	$11,758,605	−25.3%	4.64%
VERA	Vera Therapeutics, Inc. Healthcare	Reduced	758,355	-216,872	$10,397,047	−33.6%	4.10%
BIIB	Biogen Inc. Healthcare	Added	40,200	+29,200	$10,331,802	+229.7%	4.07%
HRMY	Harmony Biosciences Holdings, Inc. Healthcare	Reduced	314,500	-256,000	$10,306,165	−48.7%	4.06%
RARE	Ultragenyx Pharmaceutical Inc. Healthcare	Added	250,052	+170,000	$8,914,353	+141.4%	3.52%
QURE	uniQure N.V. Healthcare	Added	1,241,500	+1,226,000	$8,330,465	+4589.8%	3.29%
AUPH	Aurinia Pharmaceuticals Inc. Healthcare	Added	1,040,530	+467,000	$8,084,918	+45.6%	3.19%
UTHR	UNITED THERAPEUTICS Corp Healthcare	Reduced	33,959	-18,800	$7,670,319	−34.1%	3.02%
VRTX	Vertex Pharmaceuticals Inc / Ma Healthcare	Held	21,000	0	$7,302,540	−1.2%	2.88%
REGN	Regeneron Pharmaceuticals, Inc. Healthcare	Reduced	8,847	-18,153	$7,280,727	−62.5%	2.87%
ILMN	Illumina, Inc. Healthcare	Held	50,500	0	$6,743,815	−26.8%	2.66%
ALNY	Alnylam Pharmaceuticals, Inc. Healthcare	Reduced	36,800	-44,800	$6,517,280	−58.0%	2.57%
AMLX	Amylyx Pharmaceuticals, Inc. Healthcare	Added	295,000	+270,000	$5,401,450	+901.7%	2.13%
KRYS	Krystal Biotech, Inc. Healthcare	Added	46,092	+147	$5,346,672	−0.9%	2.11%
AXSM	Axsome Therapeutics, Inc. Healthcare	Held	58,300	0	$4,074,587	−2.7%	1.61%
ERAS	Erasca, Inc. Healthcare	Added	1,926,000	+500,000	$3,794,220	−3.6%	1.50%
ACAD	Acadia Pharmaceuticals Inc Healthcare	Added	179,702	+28,702	$3,744,989	+3.6%	1.48%
NBIX	Neurocrine Biosciences Inc Healthcare	Reduced	28,877	-40,000	$3,248,662	−50.0%	1.28%
SRPT	Sarepta Therapeutics, Inc. Healthcare	Added	26,700	+7,900	$3,236,574	+50.3%	1.28%
RCKT	Rocket Pharmaceuticals, Inc. Healthcare	Held	156,000	0	$3,196,440	+3.1%	1.26%
DNLI	Denali Therapeutics Inc. Healthcare	Reduced	154,000	-34,000	$3,177,020	−42.7%	1.25%
XENE	Xenon Pharmaceuticals Inc. Healthcare	Added	91,500	+66,000	$3,125,640	+218.4%	1.23%
CRSP	CRISPR Therapeutics AG Healthcare	NEW	63,000	NEW	$2,859,570	NEW	1.13%
MDGL	Madrigal Pharmaceuticals, Inc. Healthcare	Held	18,300	0	$2,672,532	−36.8%	1.05%
LEGN	Legend Biotech Corp Healthcare	Held	38,000	0	$2,552,460	−2.7%	1.01%
HALO	Halozyme Therapeutics, Inc. Healthcare	Reduced	62,200	-33,300	$2,376,040	−31.0%	0.94%
ONC	BeOne Medicines Ltd. Healthcare	Added	12,700	+4,000	$2,284,349	+47.3%	0.90%
JAZZ	Jazz Pharmaceuticals plc Healthcare	Held	17,200	0	$2,226,368	+4.4%	0.88%
MIRM	Mirum Pharmaceuticals, Inc. Healthcare	Held	67,500	0	$2,133,000	+22.1%	0.84%
IOVA	Iovance Biotherapeutics, Inc. Healthcare	Added	445,000	+380,000	$2,024,750	+342.5%	0.80%
IONS	Ionis Pharmaceuticals Inc Healthcare	Held	43,000	0	$1,950,480	+10.6%	0.77%
ZLAB	Zai Lab Ltd Healthcare	Held	78,958	0	$1,919,468	−12.3%	0.76%
GMAB	Genmab A/S Healthcare	NEW	44,300	NEW	$1,562,461	NEW	0.62%
CLDX	Celldex Therapeutics, Inc. Healthcare	Held	48,099	0	$1,323,684	−18.9%	0.52%
COGT	Cogent Biosciences, Inc. Healthcare	NEW	135,000	NEW	$1,316,250	NEW	0.52%
DYN	Dyne Therapeutics, Inc. Healthcare	Reduced	137,751	-163,000	$1,234,248	−63.5%	0.49%
NVCR	NovoCure Ltd Healthcare	Added	74,000	+42,000	$1,195,100	−10.0%	0.47%
FOLD	AMICUS THERAPEUTICS, INC. Healthcare	NEW	90,000	NEW	$1,094,400	NEW	0.43%
CYTK	Cytokinetics Inc Healthcare	Held	37,000	0	$1,090,020	−9.7%	0.43%
GH	Guardant Health, Inc. Healthcare	Held	36,500	0	$1,081,860	−17.2%	0.43%
INSM	INSMED Inc Healthcare	Held	40,100	0	$1,012,525	+19.7%	0.40%
NTLA	Intellia Therapeutics, Inc. Healthcare	Held	24,000	0	$758,880	−22.5%	0.30%
PRTA	Prothena Corp Public Ltd Co Healthcare	NEW	15,000	NEW	$723,750	NEW	0.29%
AGIO	Agios Pharmaceuticals, Inc. Healthcare	Held	24,000	0	$594,000	−12.6%	0.23%
BEAM	Beam Therapeutics Inc. Healthcare	Held	23,500	0	$565,175	−24.7%	0.22%
VIR	Vir Biotechnology, Inc. Healthcare	NEW	47,000	NEW	$440,390	NEW	0.17%