PYXS · Pyxis Oncology, Inc.

$3.08 -0.04 (-1.28%) At close · Aug 21

Market Cap

$256.90M

83.41M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Quarter:

Holders: 79

Total Value: $104,431,345

Total Shares: 34,694,814

Institutional Ownership Trend

19 quarters

Holder Concentration

Across 79 13F filers · Δ vs Mar 31, 2026

Top Holder

28.9%

+3.5 pts

Top 5

72.1%

+2.8 pts

Top 10

83.4%

+0.8 pts

HHI

1,528

Moderately concentrated+218

Quarterly Activity

vs Mar 31, 2026

New

Increased

Decreased

Sold Out

Unchanged

Holder count: +1

Institutional value: +158.2%

Shares held: +25.2%

Top Buyers

vs Mar 31, 2026

Institution	Added	Now Holds
Small GordonMD Global Investments LP	+5,903,039	10,024,909
Small Atle Fund Management AB	+769,423	966,459
Large MARSHALL WACE, LLP	+476,127	830,544
Mega BlackRock, Inc.	+79,095	867,934
Mega BANK OF AMERICA CORP /DE/	+63,657	80,464

Top Sellers

vs Mar 31, 2026

Institution	Sold	Now Holds
Mid 683 Capital Management, LLC	−436,896	459,367
Mega MILLENNIUM MANAGEMENT LLC	−164,621	233,004
Mid Longaeva Partners L.P.	−149,632	353,582
Small Palo Alto Investors LP	−146,233	864,277
Large RENAISSANCE TECHNOLOGIES LLC	−116,448	772,232

Top New Positions

vs Mar 31, 2026

Institution	Acquired	Value (USD)
Large Woodline Partners LP	523,999	$1,577,236
Small DIADEMA PARTNERS LP	388,200	$1,168,482
Small MYDA Advisors LLC	50,000	$150,500
Large Quadrature Capital Ltd	47,067	$141,671
Small Verdad Advisers, LP	44,899	$135,145

Top Sold-Out Positions

vs Mar 31, 2026

Institution	Previously Held	Last Value (USD)
Large PANAGORA ASSET MANAGEMENT INC	69,424	$101,359
Large TORONTO DOMINION BANK	50,000	$73,000
Small Maia Wealth LLC	21,277	$31,064
Mid Catalyst Funds Management Pty Ltd	20,400	$29,784
Large Squarepoint Ops LLC	17,537	$25,604

Filter: New 11 Increased 25 Reduced 24 Sold out 10 Unchanged 19

Showing 82 of 82

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

GordonMD Global Investments LP

$30,174,976

28.89%

10,024,909

Pfizer Inc

$21,168,637

20.27%

7,032,770

Laurion Capital Management LP

$14,751,672

14.13%

4,900,888

VANGUARD CAPITAL MANAGEMENT LLC

$6,248,750

5.98%

2,075,997

Atle Fund Management AB

$2,909,041

2.79%

966,459

BlackRock, Inc.

$2,612,479

2.50%

867,934

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BlackRock Investment Management, LLC	11,276	$33,940	1.3%	Sole
BlackRock Fund Advisors	545,164	$1,640,943	62.8%	Sole
BlackRock Institutional Trust Company, N.A.	269,248	$810,436	31.0%	Sole
BlackRock Asset Management Ireland Ltd	42,246	$127,160	4.9%	Sole

Palo Alto Investors LP

$2,601,473

2.49%

864,277

MARSHALL WACE, LLP

$2,499,936

2.39%

830,544

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Marshall Wace North America L.P. joint	830,544	$2,499,936	100.0%	Other

RENAISSANCE TECHNOLOGIES LLC

$2,324,418

2.23%

772,232

GEODE CAPITAL MANAGEMENT, LLC

$1,781,464

1.71%

591,849

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC	114,251	$343,895	19.3%	Defined
Held directly	477,598	$1,437,569	80.7%	Defined

Woodline Partners LP

$1,577,236

1.51%

523,999

683 Capital Management, LLC

$1,382,694

1.32%

459,367

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
683 Capital Partners, LP	459,367	$1,382,694	100.0%	Defined

JACOBS LEVY EQUITY MANAGEMENT, INC

$1,290,104

1.24%

428,606

DIADEMA PARTNERS LP

$1,168,482

1.12%

388,200

Longaeva Partners L.P.

$1,064,281

1.02%

353,582

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Balyasny Asset Management L.P.	353,582	$1,064,281	100.0%	Other

Decheng Capital LLC

$983,698

0.94%

326,810

VANGUARD FIDUCIARY TRUST CO

$911,987

0.87%

302,986

JANE STREET GROUP, LLC

$873,170

0.84%

290,090

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	177,606	$534,594	61.2%	Defined
Jane Street Global Trading, LLC	112,484	$338,576	38.8%	Defined

STATE STREET CORP

$748,999

0.72%

248,837

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STATE STREET GLOBAL ADVISORS TRUST COMPANY	248,837	$748,999	100.0%	Defined

MILLENNIUM MANAGEMENT LLC

$701,342

0.67%

233,004

UBS Group AG

$467,202

0.45%

155,217

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Financial Services Inc	2,800	$8,428	1.8%	Defined
UBS AG	150,344	$452,535	96.9%	Defined
UBS Securities LLC	2,073	$6,239	1.3%	Defined

Bank of New York Mellon Corp

$403,327

0.39%

133,996

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
The Bank of New York Mellon	6,342	$19,089	4.7%	Defined
Newton Investment Management North America, LLC	127,652	$384,232	95.3%	Defined
Held directly	2	$6	0.0%	Defined

ACADIAN ASSET MANAGEMENT LLC

$381,646

0.37%

126,793

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Acadian Inc	126,793	$381,646	100.0%	Defined

NORTHERN TRUST CORP

$373,116

0.36%

123,959

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NORTHERN TRUST CO joint	123,959	$373,116	100.0%	Defined

NewEdge Wealth, LLC

$349,178

0.33%

116,006

XTX Topco Ltd

$333,926

0.32%

110,939

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
XTX EXECUTION SERVICES LLC joint	110,939	$333,926	100.0%	Defined

TWO SIGMA INVESTMENTS, LP

$252,722

0.24%

83,961

BRIDGEWAY CAPITAL MANAGEMENT, LLC

$244,592

0.23%

81,260

BANK OF AMERICA CORP /DE/

$242,196

0.23%

80,464

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF AMERICA NA	80,464	$242,196	100.0%	Defined

JANE STREET GROUP, LLC

$221,837

0.21%

73,700

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	73,700	$221,837	100.0%	Defined

STIFEL FINANCIAL CORP

$212,015

0.20%

70,437

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STIFEL NICOLAUS & CO INC \MO\	70,200	$211,302	99.7%	Defined
Held directly	237	$713	0.3%	Defined

Cable Car Capital, LP

$185,434

0.18%

61,606

MYDA Advisors LLC

$150,500

0.14%

50,000

Qube Research & Technologies Ltd

$150,295

0.14%

49,932

UNIVERSITY OF CHICAGO

$146,680

0.14%

48,731

CITADEL ADVISORS LLC

$142,424

0.14%

47,317

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	47,317	$142,424	100.0%	Defined

Quadrature Capital Ltd

$141,671

0.14%

47,067

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Quadrature US Inc.	47,067	$141,671	100.0%	Other

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$139,062

0.13%

46,200

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	46,200	$139,062	100.0%	Other

GOLDMAN SACHS GROUP INC

$138,159

0.13%

45,900

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	45,900	$138,159	100.0%	Defined

Verdad Advisers, LP

$135,145

0.13%

44,899

LPL Financial LLC

$131,097

0.13%

43,554

COMMONWEALTH EQUITY SERVICES, LLC

$127,789

0.12%

42,455

J. Derek Lewis & Associates Inc.

$126,420

0.12%

42,000

CITIGROUP INC

$114,997

0.11%

38,205

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citigroup Financial Products Inc. joint	38,205	$114,997	100.0%	Defined

SIMPLEX TRADING, LLC

$114,085

0.11%

37,902

Point72 Asset Management, L.P.

$111,646

0.11%

37,092

Walleye Capital LLC

$110,701

0.11%

36,778

DIMENSIONAL FUND ADVISORS LP

$108,885

0.10%

36,175

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Dimensional Ireland Ltd	8,791	$26,460	24.3%	Defined
Held directly	27,384	$82,425	75.7%	Sole

MORGAN STANLEY

$100,677

0.10%

33,448

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO. LLC	1,384	$4,165	4.1%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	31,714	$95,459	94.8%	Defined
MORGAN STANLEY SMITH BARNEY LLC	350	$1,053	1.0%	Defined

MACKENZIE FINANCIAL CORP

$79,292

0.08%

26,343

Cetera Investment Advisers

$75,250

0.07%

25,000

Graham Capital Management, L.P.

$68,351

0.07%

22,708

Vanguard Global Advisers, LLC

$63,938

0.06%

21,242

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$56,889

0.05%

18,900

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	18,900	$56,889	100.0%	Other

OSAIC HOLDINGS, INC.

$53,340

0.05%

17,721

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
OSAIC WEALTH, INC.	17,721	$53,340	100.0%	Defined

GROUP ONE TRADING LLC

$49,604

0.05%

16,480

CITADEL ADVISORS LLC

$44,247

0.04%

14,700

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	14,700	$44,247	100.0%	Defined

FMR LLC

$37,271

0.04%

12,383

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC	11,894	$35,800	96.1%	Defined
STRATEGIC ADVISERS LLC	489	$1,471	3.9%	Defined

PACES FERRY WEALTH ADVISORS, LLC

$34,434

0.03%

11,440

NewEdge Advisors, LLC

$30,852

0.03%

10,250

China Universal Asset Management Co., Ltd.

$30,349

0.03%

10,083

Tower Research Capital LLC (TRC)

$28,287

0.03%

9,398

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Latour Trading LLC (Latour)	9,398	$28,287	100.0%	Defined

PNC FINANCIAL SERVICES GROUP, INC.

$19,565

0.02%

6,500

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
PNC Bank, National Association	6,500	$19,565	100.0%	Defined

Winthrop Capital Management, LLC

$18,060

0.02%

6,000

JPMORGAN CHASE & CO

$16,689

0.02%

5,545

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JPMorgan Chase Bank, N.A.	272	$818	4.9%	Defined
J.P. Morgan Securities plc	5,273	$15,871	95.1%	Defined

HAGER INVESTMENT MANAGEMENT SERVICES, LLC

$15,050

0.01%

5,000

BARCLAYS PLC

$14,052

0.01%

4,669

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BARCLAYS BANK PLC	4,091	$12,313	87.6%	Defined
BARCLAYS CAPITAL INC.	578	$1,739	12.4%	Defined

Federation des caisses Desjardins du Quebec

$13,545

0.01%

4,500

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Desjardins Securities inc.	4,500	$13,545	100.0%	Defined

FEDERATED HERMES, INC.

$8,915

0.01%

2,962

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
FEDERATED MDTA LLC	2,962	$8,915	100.0%	Defined

Mirae Asset Global Investments Co., Ltd.

$8,527

0.01%

2,833

BNP PARIBAS ARBITRAGE, SA

$8,093

0.01%

2,689

FIRST UNITED BANK & TRUST

$7,525

0.01%

2,500

GF FUND MANAGEMENT CO. LTD.

$3,690

0.00%

1,226

Persistent Asset Partners Ltd

$2,979

0.00%

990

NISA INVESTMENT ADVISORS, LLC

$2,892

0.00%

961

Physician Wealth Advisors, Inc.

$2,838

0.00%

943

SBI Securities Co., Ltd.

$1,532

0.00%

509

JONES FINANCIAL COMPANIES LLLP

$1,505

0.00%

500

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Edward D. Jones & Co., L.P.	500	$1,505	100.0%	Sole

WELLS FARGO & COMPANY/MN

$857

0.00%

285

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLS FARGO CLEARING SERVICES, LLC	285	$857	100.0%	Defined

Cornerstone Financial Management LLC

$517

0.00%

172

Caitong International Asset Management Co., Ltd

$105

0.00%

Arax Advisory Partners

$42

0.00%

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
TD SECURITIES (USA) LLC	50,000	$73,000	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Squarepoint Capital LLP	17,537	$25,604	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RBC Capital Markets, LLC	5,839	$8,524	100.0%	Defined

Key facts CIK 1782223 CUSIP 747324101 13F (30d) 74 filings 74 filers Visit website Investor relations